Three-dimensional localisation of NANOG, OCT4, and E-CADHERIN in porcine pre- and peri-implantation embryos

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Standard

Three-dimensional localisation of NANOG, OCT4, and E-CADHERIN in porcine pre- and peri-implantation embryos. / Wolf, Xenia Asbæk; Serup, Palle; Hyttel, Poul.

I: Developmental Dynamics, Bind 240, Nr. 1, 2011, s. 204-210.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Wolf, XA, Serup, P & Hyttel, P 2011, 'Three-dimensional localisation of NANOG, OCT4, and E-CADHERIN in porcine pre- and peri-implantation embryos', Developmental Dynamics, bind 240, nr. 1, s. 204-210. https://doi.org/10.1002/dvdy.22491

APA

Wolf, X. A., Serup, P., & Hyttel, P. (2011). Three-dimensional localisation of NANOG, OCT4, and E-CADHERIN in porcine pre- and peri-implantation embryos. Developmental Dynamics, 240(1), 204-210. https://doi.org/10.1002/dvdy.22491

Vancouver

Wolf XA, Serup P, Hyttel P. Three-dimensional localisation of NANOG, OCT4, and E-CADHERIN in porcine pre- and peri-implantation embryos. Developmental Dynamics. 2011;240(1):204-210. https://doi.org/10.1002/dvdy.22491

Author

Wolf, Xenia Asbæk ; Serup, Palle ; Hyttel, Poul. / Three-dimensional localisation of NANOG, OCT4, and E-CADHERIN in porcine pre- and peri-implantation embryos. I: Developmental Dynamics. 2011 ; Bind 240, Nr. 1. s. 204-210.

Bibtex

@article{159498eadfd541d18f0168dad01818e4,
title = "Three-dimensional localisation of NANOG, OCT4, and E-CADHERIN in porcine pre- and peri-implantation embryos",
abstract = "The expression patterns of NANOG and OCT4 have previously been reported to differ markedly between mammalian species indicating distinct species-specific roles during development. We investigate the three-dimensional expression pattern of NANOG and OCT4 in porcine pre- and peri-implantation embryos. The expression of NANOG differed remarkably from that reported in other species. NANOG was not detected in the inner cell mass of hatched porcine blastocysts, but later appeared in the epiblast and hypoblast of spherical blastocysts where Rauber's layer had disintegrated. In pre-gastrulating, filamentous embryos NANOG was localised to nuclei in a minor portion of the epiblast cells in which E-CADHERIN seemed to be up-regulated and OCT4 down-regulated. Later NANOG was restricted to the potential PGCs. OCT4 was detected in inner cell mass, epiblast, and mesoderm, and we found that OCT4 expression, in contrast to earlier speculations, at least in hatched blastocysts, resembles the expression pattern in the mouse embryo.",
keywords = "Former LIFE faculty, NANOG, OCT4, E-CADHERIN, porcine pre-, peri-implantation embryos",
author = "Wolf, {Xenia Asb{\ae}k} and Palle Serup and Poul Hyttel",
year = "2011",
doi = "10.1002/dvdy.22491",
language = "English",
volume = "240",
pages = "204--210",
journal = "Developmental Dynamics",
issn = "1058-8388",
publisher = "JohnWiley & Sons, Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Three-dimensional localisation of NANOG, OCT4, and E-CADHERIN in porcine pre- and peri-implantation embryos

AU - Wolf, Xenia Asbæk

AU - Serup, Palle

AU - Hyttel, Poul

PY - 2011

Y1 - 2011

N2 - The expression patterns of NANOG and OCT4 have previously been reported to differ markedly between mammalian species indicating distinct species-specific roles during development. We investigate the three-dimensional expression pattern of NANOG and OCT4 in porcine pre- and peri-implantation embryos. The expression of NANOG differed remarkably from that reported in other species. NANOG was not detected in the inner cell mass of hatched porcine blastocysts, but later appeared in the epiblast and hypoblast of spherical blastocysts where Rauber's layer had disintegrated. In pre-gastrulating, filamentous embryos NANOG was localised to nuclei in a minor portion of the epiblast cells in which E-CADHERIN seemed to be up-regulated and OCT4 down-regulated. Later NANOG was restricted to the potential PGCs. OCT4 was detected in inner cell mass, epiblast, and mesoderm, and we found that OCT4 expression, in contrast to earlier speculations, at least in hatched blastocysts, resembles the expression pattern in the mouse embryo.

AB - The expression patterns of NANOG and OCT4 have previously been reported to differ markedly between mammalian species indicating distinct species-specific roles during development. We investigate the three-dimensional expression pattern of NANOG and OCT4 in porcine pre- and peri-implantation embryos. The expression of NANOG differed remarkably from that reported in other species. NANOG was not detected in the inner cell mass of hatched porcine blastocysts, but later appeared in the epiblast and hypoblast of spherical blastocysts where Rauber's layer had disintegrated. In pre-gastrulating, filamentous embryos NANOG was localised to nuclei in a minor portion of the epiblast cells in which E-CADHERIN seemed to be up-regulated and OCT4 down-regulated. Later NANOG was restricted to the potential PGCs. OCT4 was detected in inner cell mass, epiblast, and mesoderm, and we found that OCT4 expression, in contrast to earlier speculations, at least in hatched blastocysts, resembles the expression pattern in the mouse embryo.

KW - Former LIFE faculty

KW - NANOG

KW - OCT4

KW - E-CADHERIN

KW - porcine pre-

KW - peri-implantation embryos

U2 - 10.1002/dvdy.22491

DO - 10.1002/dvdy.22491

M3 - Journal article

C2 - 21089074

VL - 240

SP - 204

EP - 210

JO - Developmental Dynamics

JF - Developmental Dynamics

SN - 1058-8388

IS - 1

ER -

ID: 32351087