Thoracic epidural analgesia reduces gastric microcirculation in the pig

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Thoracic epidural analgesia reduces gastric microcirculation in the pig. / Ambrus, Rikard; Strandby, Rune B; Secher, Niels H.; Runitz, Kim; Svendsen, Morten Bo Søndergaard; Petersen, Lonnie Grove; Achiam, Michael Patrick; Svendsen, Lars Bo.

I: BMC Anesthesiology, Bind 16, 86, 2016, s. 1-8.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Ambrus, R, Strandby, RB, Secher, NH, Runitz, K, Svendsen, MBS, Petersen, LG, Achiam, MP & Svendsen, LB 2016, 'Thoracic epidural analgesia reduces gastric microcirculation in the pig' BMC Anesthesiology, bind 16, 86, s. 1-8. https://doi.org/10.1186/s12871-016-0256-4

APA

Ambrus, R., Strandby, R. B., Secher, N. H., Runitz, K., Svendsen, M. B. S., Petersen, L. G., ... Svendsen, L. B. (2016). Thoracic epidural analgesia reduces gastric microcirculation in the pig. BMC Anesthesiology, 16, 1-8. [86]. https://doi.org/10.1186/s12871-016-0256-4

Vancouver

Ambrus R, Strandby RB, Secher NH, Runitz K, Svendsen MBS, Petersen LG o.a. Thoracic epidural analgesia reduces gastric microcirculation in the pig. BMC Anesthesiology. 2016;16:1-8. 86. https://doi.org/10.1186/s12871-016-0256-4

Author

Ambrus, Rikard ; Strandby, Rune B ; Secher, Niels H. ; Runitz, Kim ; Svendsen, Morten Bo Søndergaard ; Petersen, Lonnie Grove ; Achiam, Michael Patrick ; Svendsen, Lars Bo. / Thoracic epidural analgesia reduces gastric microcirculation in the pig. I: BMC Anesthesiology. 2016 ; Bind 16. s. 1-8.

Bibtex

@article{1f490249bfbb4fef9c74f8dc4fbf0b12,
title = "Thoracic epidural analgesia reduces gastric microcirculation in the pig",
abstract = "BACKGROUND: Thoracic epidural analgesia (TEA) is used for pain relief during and after abdominal surgery, but the effect of TEA on the splanchnic microcirculation remains debated. We evaluated whether TEA affects splanchnic microcirculation in the pig.METHODS: Splanchnic microcirculation was assessed in nine pigs prior to and 15 and 30 min after induction of TEA. Regional blood flow was assessed by neutron activated microspheres and changes in microcirculation by laser speckle contrast imaging (LSCI).RESULTS: As assessed by LSCI 15 min following TEA, gastric arteriolar flow decreased by 22 {\%} at the antrum (p = 0.020) and by 19 {\%} at the corpus (p = 0.029) of the stomach. In parallel, the microcirculation decreased by 19 {\%} at the antrum (p = 0.015) and by 20 {\%} at the corpus (p = 0.028). Reduced arteriolar flow and microcirculation at the antrum was confirmed by a reduction in microsphere assessed regional blood flow 30 min following induction of TEA (p = 0.048). These manifestations took place along with a drop in systolic blood pressure (p = 0.030), but with no significant change in mean arterial pressure, cardiac output, or heart rate.CONCLUSION: The results indicate that TEA may have an adverse effect on gastric arteriolar blood flow and microcirculation. LSCI is a non-touch technique and displays changes in blood flow in real-time and may be important for further evaluation of the concern regarding the effect of thoracic epidural anesthesia on gastric microcirculation in humans.TRIAL REGISTRATIONS: Not applicable, non-human study.",
author = "Rikard Ambrus and Strandby, {Rune B} and Secher, {Niels H.} and Kim Runitz and Svendsen, {Morten Bo S{\o}ndergaard} and Petersen, {Lonnie Grove} and Achiam, {Michael Patrick} and Svendsen, {Lars Bo}",
year = "2016",
doi = "10.1186/s12871-016-0256-4",
language = "English",
volume = "16",
pages = "1--8",
journal = "B M C Anesthesiology",
issn = "1471-2253",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Thoracic epidural analgesia reduces gastric microcirculation in the pig

AU - Ambrus, Rikard

AU - Strandby, Rune B

AU - Secher, Niels H.

AU - Runitz, Kim

AU - Svendsen, Morten Bo Søndergaard

AU - Petersen, Lonnie Grove

AU - Achiam, Michael Patrick

AU - Svendsen, Lars Bo

PY - 2016

Y1 - 2016

N2 - BACKGROUND: Thoracic epidural analgesia (TEA) is used for pain relief during and after abdominal surgery, but the effect of TEA on the splanchnic microcirculation remains debated. We evaluated whether TEA affects splanchnic microcirculation in the pig.METHODS: Splanchnic microcirculation was assessed in nine pigs prior to and 15 and 30 min after induction of TEA. Regional blood flow was assessed by neutron activated microspheres and changes in microcirculation by laser speckle contrast imaging (LSCI).RESULTS: As assessed by LSCI 15 min following TEA, gastric arteriolar flow decreased by 22 % at the antrum (p = 0.020) and by 19 % at the corpus (p = 0.029) of the stomach. In parallel, the microcirculation decreased by 19 % at the antrum (p = 0.015) and by 20 % at the corpus (p = 0.028). Reduced arteriolar flow and microcirculation at the antrum was confirmed by a reduction in microsphere assessed regional blood flow 30 min following induction of TEA (p = 0.048). These manifestations took place along with a drop in systolic blood pressure (p = 0.030), but with no significant change in mean arterial pressure, cardiac output, or heart rate.CONCLUSION: The results indicate that TEA may have an adverse effect on gastric arteriolar blood flow and microcirculation. LSCI is a non-touch technique and displays changes in blood flow in real-time and may be important for further evaluation of the concern regarding the effect of thoracic epidural anesthesia on gastric microcirculation in humans.TRIAL REGISTRATIONS: Not applicable, non-human study.

AB - BACKGROUND: Thoracic epidural analgesia (TEA) is used for pain relief during and after abdominal surgery, but the effect of TEA on the splanchnic microcirculation remains debated. We evaluated whether TEA affects splanchnic microcirculation in the pig.METHODS: Splanchnic microcirculation was assessed in nine pigs prior to and 15 and 30 min after induction of TEA. Regional blood flow was assessed by neutron activated microspheres and changes in microcirculation by laser speckle contrast imaging (LSCI).RESULTS: As assessed by LSCI 15 min following TEA, gastric arteriolar flow decreased by 22 % at the antrum (p = 0.020) and by 19 % at the corpus (p = 0.029) of the stomach. In parallel, the microcirculation decreased by 19 % at the antrum (p = 0.015) and by 20 % at the corpus (p = 0.028). Reduced arteriolar flow and microcirculation at the antrum was confirmed by a reduction in microsphere assessed regional blood flow 30 min following induction of TEA (p = 0.048). These manifestations took place along with a drop in systolic blood pressure (p = 0.030), but with no significant change in mean arterial pressure, cardiac output, or heart rate.CONCLUSION: The results indicate that TEA may have an adverse effect on gastric arteriolar blood flow and microcirculation. LSCI is a non-touch technique and displays changes in blood flow in real-time and may be important for further evaluation of the concern regarding the effect of thoracic epidural anesthesia on gastric microcirculation in humans.TRIAL REGISTRATIONS: Not applicable, non-human study.

U2 - 10.1186/s12871-016-0256-4

DO - 10.1186/s12871-016-0256-4

M3 - Journal article

VL - 16

SP - 1

EP - 8

JO - B M C Anesthesiology

JF - B M C Anesthesiology

SN - 1471-2253

M1 - 86

ER -

ID: 169017340