The nephron-arterial network and its interactions
Publikation: Bidrag til tidsskrift › Review › fagfællebedømt
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The nephron-arterial network and its interactions. / Marsh, Donald J; Postnov, Dmitry D; Sosnovtseva, Olga V; Holstein-Rathlou, Niels-Henrik.
I: American Journal of Physiology: Renal Physiology, Bind 316, Nr. 5, 2019, s. F769-F784.Publikation: Bidrag til tidsskrift › Review › fagfællebedømt
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TY - JOUR
T1 - The nephron-arterial network and its interactions
AU - Marsh, Donald J
AU - Postnov, Dmitry D
AU - Sosnovtseva, Olga V
AU - Holstein-Rathlou, Niels-Henrik
PY - 2019
Y1 - 2019
N2 - Tubuloglomerular feedback and the myogenic mechanism form an ensemble in renal afferent arterioles that regulates single nephron blood flow and glomerular filtration. Each mechanism generates a self-sustained oscillation, the mechanisms interact, and the oscillations synchronize. The synchronization generates a bimodal electrical signal in the arteriolar wall that propagates retrograde to a vascular node where it meets similar electrical signals from other nephrons. Each signal carries information about the time dependent behavior of the regulatory ensemble. The converging signals support synchronization of the nephrons participating in the information exchange, and the synchronization can lead to formation of nephron clusters. We review the experimental evidence and the theoretical implications of these interactions and consider additional interactions that can limit the size of nephron clusters. The architecture of the arterial tree figures prominently in these interactions.
AB - Tubuloglomerular feedback and the myogenic mechanism form an ensemble in renal afferent arterioles that regulates single nephron blood flow and glomerular filtration. Each mechanism generates a self-sustained oscillation, the mechanisms interact, and the oscillations synchronize. The synchronization generates a bimodal electrical signal in the arteriolar wall that propagates retrograde to a vascular node where it meets similar electrical signals from other nephrons. Each signal carries information about the time dependent behavior of the regulatory ensemble. The converging signals support synchronization of the nephrons participating in the information exchange, and the synchronization can lead to formation of nephron clusters. We review the experimental evidence and the theoretical implications of these interactions and consider additional interactions that can limit the size of nephron clusters. The architecture of the arterial tree figures prominently in these interactions.
U2 - 10.1152/ajprenal.00484.2018
DO - 10.1152/ajprenal.00484.2018
M3 - Review
C2 - 30759020
VL - 316
SP - F769-F784
JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
SN - 1931-857X
IS - 5
ER -
ID: 227785900