The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo

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Standard

The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo. / Panaro, Brandon L; Tough, Iain R; Engelstoft, Maja S; Matthews, Robert T; Digby, Gregory J; Møller, Cathrine L; Svendsen, Berit; Gribble, Fiona; Reimann, Frank; Holst, Jens Juul; Holst, Birgitte; Schwartz, Thue W; Cox, Helen M; Cone, Roger D.

I: Cell Metabolism, Bind 20, Nr. 6, 02.12.2014, s. 1018-29.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Panaro, BL, Tough, IR, Engelstoft, MS, Matthews, RT, Digby, GJ, Møller, CL, Svendsen, B, Gribble, F, Reimann, F, Holst, JJ, Holst, B, Schwartz, TW, Cox, HM & Cone, RD 2014, 'The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo', Cell Metabolism, bind 20, nr. 6, s. 1018-29. https://doi.org/10.1016/j.cmet.2014.10.004

APA

Panaro, B. L., Tough, I. R., Engelstoft, M. S., Matthews, R. T., Digby, G. J., Møller, C. L., Svendsen, B., Gribble, F., Reimann, F., Holst, J. J., Holst, B., Schwartz, T. W., Cox, H. M., & Cone, R. D. (2014). The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo. Cell Metabolism, 20(6), 1018-29. https://doi.org/10.1016/j.cmet.2014.10.004

Vancouver

Panaro BL, Tough IR, Engelstoft MS, Matthews RT, Digby GJ, Møller CL o.a. The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo. Cell Metabolism. 2014 dec. 2;20(6):1018-29. https://doi.org/10.1016/j.cmet.2014.10.004

Author

Panaro, Brandon L ; Tough, Iain R ; Engelstoft, Maja S ; Matthews, Robert T ; Digby, Gregory J ; Møller, Cathrine L ; Svendsen, Berit ; Gribble, Fiona ; Reimann, Frank ; Holst, Jens Juul ; Holst, Birgitte ; Schwartz, Thue W ; Cox, Helen M ; Cone, Roger D. / The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo. I: Cell Metabolism. 2014 ; Bind 20, Nr. 6. s. 1018-29.

Bibtex

@article{614938dbab98456f91f9adc516aacada,
title = "The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo",
abstract = "The melanocortin-4 receptor (MC4R) is expressed in the brainstem and vagal afferent nerves and regulates a number of aspects of gastrointestinal function. Here we show that the receptor is also diffusely expressed in cells of the gastrointestinal system, from stomach to descending colon. Furthermore, MC4R is the second most highly enriched GPCR in peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) expressing enteroendocrine L cells. When vectorial ion transport is measured across mouse or human intestinal mucosa, administration of α-MSH induces a MC4R-specific PYY-dependent antisecretory response consistent with a role for the MC4R in paracrine inhibition of electrolyte secretion. Finally, MC4R-dependent acute PYY and GLP-1 release from L cells can be stimulated in vivo by intraperitoneal (i.p.) administration of melanocortin peptides to mice. This suggests physiological significance for MC4R in L cells and indicates a previously unrecognized peripheral role for the MC4R, complementing vagal and central receptor functions.",
author = "Panaro, {Brandon L} and Tough, {Iain R} and Engelstoft, {Maja S} and Matthews, {Robert T} and Digby, {Gregory J} and M{\o}ller, {Cathrine L} and Berit Svendsen and Fiona Gribble and Frank Reimann and Holst, {Jens Juul} and Birgitte Holst and Schwartz, {Thue W} and Cox, {Helen M} and Cone, {Roger D}",
note = "Copyright {\textcopyright} 2014 Elsevier Inc. All rights reserved.",
year = "2014",
month = dec,
day = "2",
doi = "10.1016/j.cmet.2014.10.004",
language = "English",
volume = "20",
pages = "1018--29",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo

AU - Panaro, Brandon L

AU - Tough, Iain R

AU - Engelstoft, Maja S

AU - Matthews, Robert T

AU - Digby, Gregory J

AU - Møller, Cathrine L

AU - Svendsen, Berit

AU - Gribble, Fiona

AU - Reimann, Frank

AU - Holst, Jens Juul

AU - Holst, Birgitte

AU - Schwartz, Thue W

AU - Cox, Helen M

AU - Cone, Roger D

N1 - Copyright © 2014 Elsevier Inc. All rights reserved.

PY - 2014/12/2

Y1 - 2014/12/2

N2 - The melanocortin-4 receptor (MC4R) is expressed in the brainstem and vagal afferent nerves and regulates a number of aspects of gastrointestinal function. Here we show that the receptor is also diffusely expressed in cells of the gastrointestinal system, from stomach to descending colon. Furthermore, MC4R is the second most highly enriched GPCR in peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) expressing enteroendocrine L cells. When vectorial ion transport is measured across mouse or human intestinal mucosa, administration of α-MSH induces a MC4R-specific PYY-dependent antisecretory response consistent with a role for the MC4R in paracrine inhibition of electrolyte secretion. Finally, MC4R-dependent acute PYY and GLP-1 release from L cells can be stimulated in vivo by intraperitoneal (i.p.) administration of melanocortin peptides to mice. This suggests physiological significance for MC4R in L cells and indicates a previously unrecognized peripheral role for the MC4R, complementing vagal and central receptor functions.

AB - The melanocortin-4 receptor (MC4R) is expressed in the brainstem and vagal afferent nerves and regulates a number of aspects of gastrointestinal function. Here we show that the receptor is also diffusely expressed in cells of the gastrointestinal system, from stomach to descending colon. Furthermore, MC4R is the second most highly enriched GPCR in peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) expressing enteroendocrine L cells. When vectorial ion transport is measured across mouse or human intestinal mucosa, administration of α-MSH induces a MC4R-specific PYY-dependent antisecretory response consistent with a role for the MC4R in paracrine inhibition of electrolyte secretion. Finally, MC4R-dependent acute PYY and GLP-1 release from L cells can be stimulated in vivo by intraperitoneal (i.p.) administration of melanocortin peptides to mice. This suggests physiological significance for MC4R in L cells and indicates a previously unrecognized peripheral role for the MC4R, complementing vagal and central receptor functions.

U2 - 10.1016/j.cmet.2014.10.004

DO - 10.1016/j.cmet.2014.10.004

M3 - Journal article

C2 - 25453189

VL - 20

SP - 1018

EP - 1029

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 6

ER -

ID: 132047002