The influence of statin treatment on the inflammatory biomarkers YKL-40 and HsCRP in patients with stable coronary artery disease

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Naja Dam Mygind, Marina J Harutyunyan, Anders Bruun Mathiasen, Rasmus Sejersten Ripa, Jens Jacob Thune, Jens Peter Gøtze, Julia S Johansen, Jens Kastrup, The CLARICOR Trial Group

OBJECTIVE: The inflammatory biomarker YKL-40 is elevated and associated with mortality in patients with stable coronary artery disease (CAD). The aim was to investigate the influence of statin treatment and lipid status on serum YKL-40 and Hs-CRP in patients with stable CAD. DESIGN: Serum YKL-40, HsCRP, total cholesterol, HDL-c, LDL-c and triglycerides levels were measured in 404 statin treated and in 404 matched non-statin treated patients with stable CAD. RESULTS: YKL-40 was significantly higher in non-statin treated 110 µg/l (median) compared with 65 µg/l in statin treated (p 
OriginalsprogEngelsk
TidsskriftInflammation Research
Vol/bind60
Udgave nummer3
Sider (fra-til)281-7
Antal sider7
ISSN1023-3830
DOI
StatusUdgivet - 2011

ID: 32108354