Synthesis and radiolabeling of a polar [125 I]I-1,2,4,5-tetrazine

Synthesis and radiolabeling of a polar [¹²⁵ I]I-1,2,4,5-tetrazine

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Standard

Synthesis and radiolabeling of a polar [¹²⁵ I]I-1,2,4,5-tetrazine. / Bidesi, Natasha; Shalgunov, Vladimir; Battisti, Umberto Maria; Hvass, Lars; Jørgensen, Jesper Tranekjaer; Poulie, Christian B M; Jensen, Andreas I; Kjaer, Andreas; Herth, Matthias M.

I: Journal of Labelled Compounds and Radiopharmaceuticals, Bind 66, Nr. 1, 2023, s. 22-30.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Bidesi, N, Shalgunov, V, Battisti, UM, Hvass, L, Jørgensen, JT, Poulie, CBM, Jensen, AI, Kjaer, A & Herth, MM 2023, 'Synthesis and radiolabeling of a polar [¹²⁵ I]I-1,2,4,5-tetrazine', Journal of Labelled Compounds and Radiopharmaceuticals, bind 66, nr. 1, s. 22-30. https://doi.org/10.1002/jlcr.4009

APA

Bidesi, N., Shalgunov, V., Battisti, U. M., Hvass, L., Jørgensen, J. T., Poulie, C. B. M., Jensen, A. I., Kjaer, A., & Herth, M. M. (2023). Synthesis and radiolabeling of a polar [¹²⁵ I]I-1,2,4,5-tetrazine. Journal of Labelled Compounds and Radiopharmaceuticals, 66(1), 22-30. https://doi.org/10.1002/jlcr.4009

Vancouver

Bidesi N, Shalgunov V, Battisti UM, Hvass L, Jørgensen JT, Poulie CBM o.a. Synthesis and radiolabeling of a polar [¹²⁵ I]I-1,2,4,5-tetrazine. Journal of Labelled Compounds and Radiopharmaceuticals. 2023;66(1):22-30. https://doi.org/10.1002/jlcr.4009

Author

Bidesi, Natasha ; Shalgunov, Vladimir ; Battisti, Umberto Maria ; Hvass, Lars ; Jørgensen, Jesper Tranekjaer ; Poulie, Christian B M ; Jensen, Andreas I ; Kjaer, Andreas ; Herth, Matthias M. / Synthesis and radiolabeling of a polar [¹²⁵ I]I-1,2,4,5-tetrazine. I: Journal of Labelled Compounds and Radiopharmaceuticals. 2023 ; Bind 66, Nr. 1. s. 22-30.

Bibtex

@article{0f001b79262542d2969eaa36236a4c35,

title = "Synthesis and radiolabeling of a polar [125 I]I-1,2,4,5-tetrazine",

abstract = "Pretargeting imaging has gained a lot of prominence, due to its excellent bioorthogonality and improved imaging contrast compared to conventional imaging. A new iodo tetrazine (Tz) derivative has been synthesized and further developed into the corresponding iodine-125 ( 125 I) analog (12), via the trimethylstannane precursor. Radiolabeling with either N-chlorosuccinimide or chloramine-T, in either MeCN or MeOH proceeded with a radiochemical conversion (RCC) of >80%. Subsequent deprotection only proved successful, among the tested conditions, when the radiolabeled Tz was stirred in 6-M HCl (aq.) at 60°C for 2.5 h. To the best of our knowledge, this is the first H-tetrazine labeled with iodine. In vivo investigations on the pretargeting ability of 12 are currently under way. ",

author = "Natasha Bidesi and Vladimir Shalgunov and Battisti, {Umberto Maria} and Lars Hvass and J{\o}rgensen, {Jesper Tranekjaer} and Poulie, {Christian B M} and Jensen, {Andreas I} and Andreas Kjaer and Herth, {Matthias M}",

note = "{\textcopyright} 2022 The Authors. Journal of Labelled Compounds and Radiopharmaceuticals published by John Wiley & Sons Ltd.",

year = "2023",

doi = "10.1002/jlcr.4009",

language = "English",

volume = "66",

pages = "22--30",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

issn = "0362-4803",

publisher = "JohnWiley & Sons Ltd",

number = "1",

}

RIS

TY - JOUR

T1 - Synthesis and radiolabeling of a polar [125 I]I-1,2,4,5-tetrazine

AU - Bidesi, Natasha

AU - Shalgunov, Vladimir

AU - Battisti, Umberto Maria

AU - Hvass, Lars

AU - Jørgensen, Jesper Tranekjaer

AU - Poulie, Christian B M

AU - Jensen, Andreas I

AU - Kjaer, Andreas

AU - Herth, Matthias M

PY - 2023

Y1 - 2023

N2 - Pretargeting imaging has gained a lot of prominence, due to its excellent bioorthogonality and improved imaging contrast compared to conventional imaging. A new iodo tetrazine (Tz) derivative has been synthesized and further developed into the corresponding iodine-125 ( 125 I) analog (12), via the trimethylstannane precursor. Radiolabeling with either N-chlorosuccinimide or chloramine-T, in either MeCN or MeOH proceeded with a radiochemical conversion (RCC) of >80%. Subsequent deprotection only proved successful, among the tested conditions, when the radiolabeled Tz was stirred in 6-M HCl (aq.) at 60°C for 2.5 h. To the best of our knowledge, this is the first H-tetrazine labeled with iodine. In vivo investigations on the pretargeting ability of 12 are currently under way.

AB - Pretargeting imaging has gained a lot of prominence, due to its excellent bioorthogonality and improved imaging contrast compared to conventional imaging. A new iodo tetrazine (Tz) derivative has been synthesized and further developed into the corresponding iodine-125 ( 125 I) analog (12), via the trimethylstannane precursor. Radiolabeling with either N-chlorosuccinimide or chloramine-T, in either MeCN or MeOH proceeded with a radiochemical conversion (RCC) of >80%. Subsequent deprotection only proved successful, among the tested conditions, when the radiolabeled Tz was stirred in 6-M HCl (aq.) at 60°C for 2.5 h. To the best of our knowledge, this is the first H-tetrazine labeled with iodine. In vivo investigations on the pretargeting ability of 12 are currently under way.

U2 - 10.1002/jlcr.4009

DO - 10.1002/jlcr.4009

M3 - Journal article

C2 - 36539610

VL - 66

SP - 22

EP - 30

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

SN - 0362-4803

IS - 1

ER -

ID: 333698997

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