Staging of early lymph node metastases with the sentinel lymph node technique and predictive factors in T1/T2 oral cavity cancer: A retrospective single-center study
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Staging of early lymph node metastases with the sentinel lymph node technique and predictive factors in T1/T2 oral cavity cancer : A retrospective single-center study. / Pedersen, Nicklas Juel; Jensen, David Hebbelstrup; Hedbäck, Nora; Frendø, Martin; Kiss, Katalin; Lelkaitis, Giedrius; Mortensen, Jann; Christensen, Anders; Specht, Lena; von Buchwald, Christian.
I: Head & Neck (Print Edition), Bind 38, Nr. S1, 03.06.2015, s. 1-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Staging of early lymph node metastases with the sentinel lymph node technique and predictive factors in T1/T2 oral cavity cancer
T2 - A retrospective single-center study
AU - Pedersen, Nicklas Juel
AU - Jensen, David Hebbelstrup
AU - Hedbäck, Nora
AU - Frendø, Martin
AU - Kiss, Katalin
AU - Lelkaitis, Giedrius
AU - Mortensen, Jann
AU - Christensen, Anders
AU - Specht, Lena
AU - von Buchwald, Christian
N1 - © 2015 Wiley Periodicals, Inc.
PY - 2015/6/3
Y1 - 2015/6/3
N2 - BACKGROUND: The purpose of this study was to examine the diagnostic accuracy of detecting lymph node metastases and to identify predictive and prognostic clinicopathological factors in patients with oral squamous cell carcinoma (OSCC) undergoing sentinel lymph node biopsy (SLNB).METHODS: All patients diagnosed with cT1 to T2N0 OSCC who underwent a diagnostic SLNB between 2007 and 2013 were included.RESULTS: We identified 253 patients, of whom 27% had a positive sentinel lymph node (SLB). The false-negative rate, sensitivity, and negative predictive value (NPV) were 5%, 88%, and 95%, respectively. Patients with micrometastases as well as macrometastases had a separately, significantly shorter disease-specific survival than patients with pN0 disease. In a logistic regression model, the maximum tumor thickness, perineural invasion, and differentiation grade were independent predictive factors for the presence of metastases.CONCLUSION: These data support the use of the SLNB technique as an accurate and safe staging tool in patients with OSCC with a cN0 neck. © 2015 Wiley Periodicals, Inc. Head Neck, 2015.
AB - BACKGROUND: The purpose of this study was to examine the diagnostic accuracy of detecting lymph node metastases and to identify predictive and prognostic clinicopathological factors in patients with oral squamous cell carcinoma (OSCC) undergoing sentinel lymph node biopsy (SLNB).METHODS: All patients diagnosed with cT1 to T2N0 OSCC who underwent a diagnostic SLNB between 2007 and 2013 were included.RESULTS: We identified 253 patients, of whom 27% had a positive sentinel lymph node (SLB). The false-negative rate, sensitivity, and negative predictive value (NPV) were 5%, 88%, and 95%, respectively. Patients with micrometastases as well as macrometastases had a separately, significantly shorter disease-specific survival than patients with pN0 disease. In a logistic regression model, the maximum tumor thickness, perineural invasion, and differentiation grade were independent predictive factors for the presence of metastases.CONCLUSION: These data support the use of the SLNB technique as an accurate and safe staging tool in patients with OSCC with a cN0 neck. © 2015 Wiley Periodicals, Inc. Head Neck, 2015.
U2 - 10.1002/hed.24153
DO - 10.1002/hed.24153
M3 - Journal article
C2 - 26040238
VL - 38
SP - 1
EP - 8
JO - Head & Neck (Print Edition)
JF - Head & Neck (Print Edition)
SN - 1043-3074
IS - S1
ER -
ID: 160504425