TY - JOUR

T1 - Short-term effects of liraglutide on kidney function and vasoactive hormones in type 2 diabetes

T2 - a randomized clinical trial

AU - Skov, J.

AU - Pedersen, M.

AU - Holst, Jens Juul

AU - Madsen, B

AU - Goetze, Jens P

AU - Rittig, S.

AU - Jonassen, Thomas

AU - Frøkiær, J

AU - Dejgaard, A.

AU - Christiansen, J. S.

N1 - This article is protected by copyright. All rights reserved.

PY - 2016/2/22

Y1 - 2016/2/22

N2 - AIMS: To investigate the effects of a single dose of 1.2 mg liraglutide, a once-daily glucagon-like peptide-1 (GLP-1) receptor agonist, on key renal parameters in patients with type 2 diabetes.METHODS: The study was a placebo-controlled, double-blind, cross-over in 11 male patients with type 2 diabetes. Measurements included (51) Cr-EDTA plasma clearance estimated glomerular filtration rate (GFR) and MRI-based renal blood flow (RBF), tissue perfusion and - oxygenation.RESULTS: Liraglutide had no effect on GFR (95% CI -6.8 to 3.6 ml/min/1.73 m(2) ) or RBF (95% CI -39 to 30 ml/min) and did not change local renal blood perfusion or oxygenation. The fractional excretion of lithium increased 14% (p = 0.01) and sodium clearance tended to increase (p = 0.06). Liraglutide increased diastolic and systolic blood pressure (3 and 6 mm Hg) and heart rate (3 min(-1) ) (all p < 0.05). Angiotensin II concentration decreased 21% (p = 0.02), but there were no effects on other renin-angiotensin system components, atrial natriuretic peptides (ANP), methanephrines or the excretion of catecholamines.CONCLUSIONS: Short-term liraglutide treatment did not affect renal hemodynamics but decreased the proximal tubular sodium reabsorption. Blood pressure increased as opposed to long-term treatment. Catecholamine levels were unchanged and the results did not support a GLP-1-ANP axis. Angiotensin II levels decreased, which may contribute to renal protection by GLP-1 receptor agonists.

AB - AIMS: To investigate the effects of a single dose of 1.2 mg liraglutide, a once-daily glucagon-like peptide-1 (GLP-1) receptor agonist, on key renal parameters in patients with type 2 diabetes.METHODS: The study was a placebo-controlled, double-blind, cross-over in 11 male patients with type 2 diabetes. Measurements included (51) Cr-EDTA plasma clearance estimated glomerular filtration rate (GFR) and MRI-based renal blood flow (RBF), tissue perfusion and - oxygenation.RESULTS: Liraglutide had no effect on GFR (95% CI -6.8 to 3.6 ml/min/1.73 m(2) ) or RBF (95% CI -39 to 30 ml/min) and did not change local renal blood perfusion or oxygenation. The fractional excretion of lithium increased 14% (p = 0.01) and sodium clearance tended to increase (p = 0.06). Liraglutide increased diastolic and systolic blood pressure (3 and 6 mm Hg) and heart rate (3 min(-1) ) (all p < 0.05). Angiotensin II concentration decreased 21% (p = 0.02), but there were no effects on other renin-angiotensin system components, atrial natriuretic peptides (ANP), methanephrines or the excretion of catecholamines.CONCLUSIONS: Short-term liraglutide treatment did not affect renal hemodynamics but decreased the proximal tubular sodium reabsorption. Blood pressure increased as opposed to long-term treatment. Catecholamine levels were unchanged and the results did not support a GLP-1-ANP axis. Angiotensin II levels decreased, which may contribute to renal protection by GLP-1 receptor agonists.

U2 - 10.1111/dom.12651

DO - 10.1111/dom.12651

M3 - Journal article

C2 - 26910107

VL - 18

SP - 581

EP - 589

JO - Diabetes, Obesity and Metabolism

JF - Diabetes, Obesity and Metabolism

SN - 1462-8902

IS - 6

ER -