Schizophrenia-associated mt-DNA SNPs exhibit highly variable haplogroup affiliation and nuclear ancestry: Bi-genomic dependence raises major concerns for link to disease

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Schizophrenia-associated mt-DNA SNPs exhibit highly variable haplogroup affiliation and nuclear ancestry : Bi-genomic dependence raises major concerns for link to disease. / Hagen, Christian M.; Gonçalves, Vanessa F.; Hedley, Paula L.; Bybjerg-Grauholm, Jonas; Bækvad-Hansen, Marie; Hansen, Christine S.; Kanters, Jørgen K.; Nielsen, Jimmi; Mors, Ole; Demur, Alfonso B.; Als, Thomas D.; Nordentoft, Merete; Børglum, Anders; Mortensen, Preben B.; Kennedy, James; Werge, Thomas M.; Hougaard, David M.; Christiansen, Michael.

I: PLoS ONE, Bind 13, Nr. 12, e0208828, 01.12.2018.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Hagen, CM, Gonçalves, VF, Hedley, PL, Bybjerg-Grauholm, J, Bækvad-Hansen, M, Hansen, CS, Kanters, JK, Nielsen, J, Mors, O, Demur, AB, Als, TD, Nordentoft, M, Børglum, A, Mortensen, PB, Kennedy, J, Werge, TM, Hougaard, DM & Christiansen, M 2018, 'Schizophrenia-associated mt-DNA SNPs exhibit highly variable haplogroup affiliation and nuclear ancestry: Bi-genomic dependence raises major concerns for link to disease', PLoS ONE, bind 13, nr. 12, e0208828. https://doi.org/10.1371/journal.pone.0208828

APA

Hagen, C. M., Gonçalves, V. F., Hedley, P. L., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Hansen, C. S., Kanters, J. K., Nielsen, J., Mors, O., Demur, A. B., Als, T. D., Nordentoft, M., Børglum, A., Mortensen, P. B., Kennedy, J., Werge, T. M., Hougaard, D. M., & Christiansen, M. (2018). Schizophrenia-associated mt-DNA SNPs exhibit highly variable haplogroup affiliation and nuclear ancestry: Bi-genomic dependence raises major concerns for link to disease. PLoS ONE, 13(12), [e0208828]. https://doi.org/10.1371/journal.pone.0208828

Vancouver

Hagen CM, Gonçalves VF, Hedley PL, Bybjerg-Grauholm J, Bækvad-Hansen M, Hansen CS o.a. Schizophrenia-associated mt-DNA SNPs exhibit highly variable haplogroup affiliation and nuclear ancestry: Bi-genomic dependence raises major concerns for link to disease. PLoS ONE. 2018 dec. 1;13(12). e0208828. https://doi.org/10.1371/journal.pone.0208828

Author

Hagen, Christian M. ; Gonçalves, Vanessa F. ; Hedley, Paula L. ; Bybjerg-Grauholm, Jonas ; Bækvad-Hansen, Marie ; Hansen, Christine S. ; Kanters, Jørgen K. ; Nielsen, Jimmi ; Mors, Ole ; Demur, Alfonso B. ; Als, Thomas D. ; Nordentoft, Merete ; Børglum, Anders ; Mortensen, Preben B. ; Kennedy, James ; Werge, Thomas M. ; Hougaard, David M. ; Christiansen, Michael. / Schizophrenia-associated mt-DNA SNPs exhibit highly variable haplogroup affiliation and nuclear ancestry : Bi-genomic dependence raises major concerns for link to disease. I: PLoS ONE. 2018 ; Bind 13, Nr. 12.

Bibtex

@article{3dc89e781ab14baf923359905413cbbb,
title = "Schizophrenia-associated mt-DNA SNPs exhibit highly variable haplogroup affiliation and nuclear ancestry: Bi-genomic dependence raises major concerns for link to disease",
abstract = "Mitochondria play a significant role in human diseases. However, disease associations with mitochondrial DNA (mtDNA) SNPs have proven difficult to replicate. An analysis of eight schizophrenia-associated mtDNA SNPs, in 23,743 Danes without a psychiatric diagnosis and 2,538 schizophrenia patients, revealed marked inter-allelic differences in mitochondrial haplogroup affiliation and nuclear ancestry. This bi-genomic dependence could entail population stratification. Only two mitochondrial SNPs, m.15043A and m.15218G, were significantly associated with schizophrenia. However, these associations disappeared when corrected for haplogroup affiliation and nuclear ancestry. The extensive bi-genomic dependence documented here is a major concern when interpreting historic, as well as designing future, mtDNA association studies.",
author = "Hagen, {Christian M.} and Gon{\c c}alves, {Vanessa F.} and Hedley, {Paula L.} and Jonas Bybjerg-Grauholm and Marie B{\ae}kvad-Hansen and Hansen, {Christine S.} and Kanters, {J{\o}rgen K.} and Jimmi Nielsen and Ole Mors and Demur, {Alfonso B.} and Als, {Thomas D.} and Merete Nordentoft and Anders B{\o}rglum and Mortensen, {Preben B.} and James Kennedy and Werge, {Thomas M.} and Hougaard, {David M.} and Michael Christiansen",
year = "2018",
month = dec,
day = "1",
doi = "10.1371/journal.pone.0208828",
language = "English",
volume = "13",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "12",

}

RIS

TY - JOUR

T1 - Schizophrenia-associated mt-DNA SNPs exhibit highly variable haplogroup affiliation and nuclear ancestry

T2 - Bi-genomic dependence raises major concerns for link to disease

AU - Hagen, Christian M.

AU - Gonçalves, Vanessa F.

AU - Hedley, Paula L.

AU - Bybjerg-Grauholm, Jonas

AU - Bækvad-Hansen, Marie

AU - Hansen, Christine S.

AU - Kanters, Jørgen K.

AU - Nielsen, Jimmi

AU - Mors, Ole

AU - Demur, Alfonso B.

AU - Als, Thomas D.

AU - Nordentoft, Merete

AU - Børglum, Anders

AU - Mortensen, Preben B.

AU - Kennedy, James

AU - Werge, Thomas M.

AU - Hougaard, David M.

AU - Christiansen, Michael

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Mitochondria play a significant role in human diseases. However, disease associations with mitochondrial DNA (mtDNA) SNPs have proven difficult to replicate. An analysis of eight schizophrenia-associated mtDNA SNPs, in 23,743 Danes without a psychiatric diagnosis and 2,538 schizophrenia patients, revealed marked inter-allelic differences in mitochondrial haplogroup affiliation and nuclear ancestry. This bi-genomic dependence could entail population stratification. Only two mitochondrial SNPs, m.15043A and m.15218G, were significantly associated with schizophrenia. However, these associations disappeared when corrected for haplogroup affiliation and nuclear ancestry. The extensive bi-genomic dependence documented here is a major concern when interpreting historic, as well as designing future, mtDNA association studies.

AB - Mitochondria play a significant role in human diseases. However, disease associations with mitochondrial DNA (mtDNA) SNPs have proven difficult to replicate. An analysis of eight schizophrenia-associated mtDNA SNPs, in 23,743 Danes without a psychiatric diagnosis and 2,538 schizophrenia patients, revealed marked inter-allelic differences in mitochondrial haplogroup affiliation and nuclear ancestry. This bi-genomic dependence could entail population stratification. Only two mitochondrial SNPs, m.15043A and m.15218G, were significantly associated with schizophrenia. However, these associations disappeared when corrected for haplogroup affiliation and nuclear ancestry. The extensive bi-genomic dependence documented here is a major concern when interpreting historic, as well as designing future, mtDNA association studies.

UR - http://www.scopus.com/inward/record.url?scp=85058236229&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0208828

DO - 10.1371/journal.pone.0208828

M3 - Journal article

C2 - 30532134

AN - SCOPUS:85058236229

VL - 13

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 12

M1 - e0208828

ER -

ID: 210385506