Role of the renin-angiotensin system in regulation and autoregulation of renal blood flow.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Role of the renin-angiotensin system in regulation and autoregulation of renal blood flow. / Sørensen, Charlotte Mehlin; Leyssac, Paul Peter; Skøtt, Ole; Holstein-Rathlou, Niels-Henrik.

I: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Bind 279, Nr. 3, 2000, s. R1017-24.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Sørensen, CM, Leyssac, PP, Skøtt, O & Holstein-Rathlou, N-H 2000, 'Role of the renin-angiotensin system in regulation and autoregulation of renal blood flow.', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, bind 279, nr. 3, s. R1017-24.

APA

Sørensen, C. M., Leyssac, P. P., Skøtt, O., & Holstein-Rathlou, N-H. (2000). Role of the renin-angiotensin system in regulation and autoregulation of renal blood flow. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 279(3), R1017-24.

Vancouver

Sørensen CM, Leyssac PP, Skøtt O, Holstein-Rathlou N-H. Role of the renin-angiotensin system in regulation and autoregulation of renal blood flow. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 2000;279(3):R1017-24.

Author

Sørensen, Charlotte Mehlin ; Leyssac, Paul Peter ; Skøtt, Ole ; Holstein-Rathlou, Niels-Henrik. / Role of the renin-angiotensin system in regulation and autoregulation of renal blood flow. I: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 2000 ; Bind 279, Nr. 3. s. R1017-24.

Bibtex

@article{f0f50860fdd311ddb219000ea68e967b,
title = "Role of the renin-angiotensin system in regulation and autoregulation of renal blood flow.",
abstract = "The role for ANG II in renal blood flow (RBF) autoregulation is unsettled. The present study was designed to test the effect of clamping plasma ANG II concentrations ([ANG II]) by simultaneous infusion of the angiotensin-converting enzyme inhibitor captopril and ANG II on RBF autoregulation in halothane-anesthetized Sprague-Dawley rats. Autoregulation was defined as the RBF response to acute changes in renal perfusion pressure (RPP). Regulation was defined as changes in RBF during long-lasting changes in RPP. The results showed that a prolonged reduction of RPP reset the lower limit of autoregulation from 85 +/- 1 to 73 +/- 2 mmHg (P < 0.05) and regulated RBF to a lower level. Reduction of RPP to just above the lower limit of autoregulation (88 mmHg) induced regulation of RBF to a lower level within 10 min. Clamping [ANG II] per se reset the lower limit of autoregulation to 62 +/- 5 mmHg. In this case, reduction in RPP to 50 mmHg did not induce a downregulation of RBF. We conclude that ANG II plays an important role in the resetting of the autoregulation limits. The ability to regulate RBF to a new level as a response to changes in RPP also depends on changes in [ANG II]. Udgivelsesdato: September",
author = "S{\o}rensen, {Charlotte Mehlin} and Leyssac, {Paul Peter} and Ole Sk{\o}tt and Niels-Henrik Holstein-Rathlou",
year = "2000",
language = "English",
volume = "279",
pages = "R1017--24",
journal = "American Journal of Physiology: Regulatory, Integrative and Comparative Physiology",
issn = "0363-6119",
publisher = "American Physiological Society",
number = "3",

}

RIS

TY - JOUR

T1 - Role of the renin-angiotensin system in regulation and autoregulation of renal blood flow.

AU - Sørensen, Charlotte Mehlin

AU - Leyssac, Paul Peter

AU - Skøtt, Ole

AU - Holstein-Rathlou, Niels-Henrik

PY - 2000

Y1 - 2000

N2 - The role for ANG II in renal blood flow (RBF) autoregulation is unsettled. The present study was designed to test the effect of clamping plasma ANG II concentrations ([ANG II]) by simultaneous infusion of the angiotensin-converting enzyme inhibitor captopril and ANG II on RBF autoregulation in halothane-anesthetized Sprague-Dawley rats. Autoregulation was defined as the RBF response to acute changes in renal perfusion pressure (RPP). Regulation was defined as changes in RBF during long-lasting changes in RPP. The results showed that a prolonged reduction of RPP reset the lower limit of autoregulation from 85 +/- 1 to 73 +/- 2 mmHg (P < 0.05) and regulated RBF to a lower level. Reduction of RPP to just above the lower limit of autoregulation (88 mmHg) induced regulation of RBF to a lower level within 10 min. Clamping [ANG II] per se reset the lower limit of autoregulation to 62 +/- 5 mmHg. In this case, reduction in RPP to 50 mmHg did not induce a downregulation of RBF. We conclude that ANG II plays an important role in the resetting of the autoregulation limits. The ability to regulate RBF to a new level as a response to changes in RPP also depends on changes in [ANG II]. Udgivelsesdato: September

AB - The role for ANG II in renal blood flow (RBF) autoregulation is unsettled. The present study was designed to test the effect of clamping plasma ANG II concentrations ([ANG II]) by simultaneous infusion of the angiotensin-converting enzyme inhibitor captopril and ANG II on RBF autoregulation in halothane-anesthetized Sprague-Dawley rats. Autoregulation was defined as the RBF response to acute changes in renal perfusion pressure (RPP). Regulation was defined as changes in RBF during long-lasting changes in RPP. The results showed that a prolonged reduction of RPP reset the lower limit of autoregulation from 85 +/- 1 to 73 +/- 2 mmHg (P < 0.05) and regulated RBF to a lower level. Reduction of RPP to just above the lower limit of autoregulation (88 mmHg) induced regulation of RBF to a lower level within 10 min. Clamping [ANG II] per se reset the lower limit of autoregulation to 62 +/- 5 mmHg. In this case, reduction in RPP to 50 mmHg did not induce a downregulation of RBF. We conclude that ANG II plays an important role in the resetting of the autoregulation limits. The ability to regulate RBF to a new level as a response to changes in RPP also depends on changes in [ANG II]. Udgivelsesdato: September

M3 - Journal article

VL - 279

SP - R1017-24

JO - American Journal of Physiology: Regulatory, Integrative and Comparative Physiology

JF - American Journal of Physiology: Regulatory, Integrative and Comparative Physiology

SN - 0363-6119

IS - 3

ER -

ID: 10643712