Risk of comorbidities in patients diagnosed with chronic urticaria: A nationwide registry-study

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Standard

Risk of comorbidities in patients diagnosed with chronic urticaria : A nationwide registry-study. / Ghazanfar, Misbah Noshela; Kibsgaard, Line; Thomsen, Simon Francis; Vestergaard, Christian.

I: World Allergy Organization Journal, Bind 13, Nr. 1, 100097, 2020.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Ghazanfar, MN, Kibsgaard, L, Thomsen, SF & Vestergaard, C 2020, 'Risk of comorbidities in patients diagnosed with chronic urticaria: A nationwide registry-study', World Allergy Organization Journal, bind 13, nr. 1, 100097. https://doi.org/10.1016/j.waojou.2019.100097

APA

Ghazanfar, M. N., Kibsgaard, L., Thomsen, S. F., & Vestergaard, C. (2020). Risk of comorbidities in patients diagnosed with chronic urticaria: A nationwide registry-study. World Allergy Organization Journal, 13(1), [100097]. https://doi.org/10.1016/j.waojou.2019.100097

Vancouver

Ghazanfar MN, Kibsgaard L, Thomsen SF, Vestergaard C. Risk of comorbidities in patients diagnosed with chronic urticaria: A nationwide registry-study. World Allergy Organization Journal. 2020;13(1). 100097. https://doi.org/10.1016/j.waojou.2019.100097

Author

Ghazanfar, Misbah Noshela ; Kibsgaard, Line ; Thomsen, Simon Francis ; Vestergaard, Christian. / Risk of comorbidities in patients diagnosed with chronic urticaria : A nationwide registry-study. I: World Allergy Organization Journal. 2020 ; Bind 13, Nr. 1.

Bibtex

@article{3da90c29ff8845238e7edad17ad72de4,
title = "Risk of comorbidities in patients diagnosed with chronic urticaria: A nationwide registry-study",
abstract = "Background: The autoimmune profile of Chronic Urticaria (CU) patients is an increasing topic of interest. Associated diseases suggest shared pathogenic pathways, and they may provide important knowledge on specific targets for future treatment models. In this study we examined the prevalence and risk of comorbidities in CU.Methods: The Danish National Patient Registry was used to identify all CU patients from 1994 to 2015. Five of 5 specialized dermatological units in Denmark were covered. Analyses were conducted as a nested case control study and a matched cohort study. CSU patients were matched 1:10 on age and sex to an otherwise random group of people from the background population.Results: A total of 12,185 CU patients were identified, with an overweight of female cases (69% versus 32%). There was an overrepresentation of mast cell mediated diseases including mastocytosis and anaphylaxis, as well as atopic diseases including type 1 allergies and atopic dermatitis. The prevalence of rheumatoid arthritis, systemic lupus erythematosus, thyroiditis and vitiligo was also increased, as was the prevalence of depression. CU patients who did not have any of the comorbidities at the time of their CU diagnosis had an increased risk of developing both mast cell mediated diseases, atopic diseases, and autoimmune diseases excluding thyroiditis and diabetes.Conclusion: The autoimmune profile of the comorbidities of CU was demonstrated with an evident risk of developing rheumatoid arthritis. CU patients were also at increased risk of either having or achieving depression. Mast cell related diseases seemed to be overrepresented, although registry data within this disease category are questionable and similar to symptoms of CU to the untrained eye. Thus, CU patients constitute a multimorbid group of patients, which must be recognized among treating physicians.",
keywords = "Chronic urticaria, Demographics, Prevalence, Incident risk, Comorbidities",
author = "Ghazanfar, {Misbah Noshela} and Line Kibsgaard and Thomsen, {Simon Francis} and Christian Vestergaard",
year = "2020",
doi = "10.1016/j.waojou.2019.100097",
language = "English",
volume = "13",
journal = "The World Allergy Organization Journal",
issn = "1939-4551",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Risk of comorbidities in patients diagnosed with chronic urticaria

T2 - A nationwide registry-study

AU - Ghazanfar, Misbah Noshela

AU - Kibsgaard, Line

AU - Thomsen, Simon Francis

AU - Vestergaard, Christian

PY - 2020

Y1 - 2020

N2 - Background: The autoimmune profile of Chronic Urticaria (CU) patients is an increasing topic of interest. Associated diseases suggest shared pathogenic pathways, and they may provide important knowledge on specific targets for future treatment models. In this study we examined the prevalence and risk of comorbidities in CU.Methods: The Danish National Patient Registry was used to identify all CU patients from 1994 to 2015. Five of 5 specialized dermatological units in Denmark were covered. Analyses were conducted as a nested case control study and a matched cohort study. CSU patients were matched 1:10 on age and sex to an otherwise random group of people from the background population.Results: A total of 12,185 CU patients were identified, with an overweight of female cases (69% versus 32%). There was an overrepresentation of mast cell mediated diseases including mastocytosis and anaphylaxis, as well as atopic diseases including type 1 allergies and atopic dermatitis. The prevalence of rheumatoid arthritis, systemic lupus erythematosus, thyroiditis and vitiligo was also increased, as was the prevalence of depression. CU patients who did not have any of the comorbidities at the time of their CU diagnosis had an increased risk of developing both mast cell mediated diseases, atopic diseases, and autoimmune diseases excluding thyroiditis and diabetes.Conclusion: The autoimmune profile of the comorbidities of CU was demonstrated with an evident risk of developing rheumatoid arthritis. CU patients were also at increased risk of either having or achieving depression. Mast cell related diseases seemed to be overrepresented, although registry data within this disease category are questionable and similar to symptoms of CU to the untrained eye. Thus, CU patients constitute a multimorbid group of patients, which must be recognized among treating physicians.

AB - Background: The autoimmune profile of Chronic Urticaria (CU) patients is an increasing topic of interest. Associated diseases suggest shared pathogenic pathways, and they may provide important knowledge on specific targets for future treatment models. In this study we examined the prevalence and risk of comorbidities in CU.Methods: The Danish National Patient Registry was used to identify all CU patients from 1994 to 2015. Five of 5 specialized dermatological units in Denmark were covered. Analyses were conducted as a nested case control study and a matched cohort study. CSU patients were matched 1:10 on age and sex to an otherwise random group of people from the background population.Results: A total of 12,185 CU patients were identified, with an overweight of female cases (69% versus 32%). There was an overrepresentation of mast cell mediated diseases including mastocytosis and anaphylaxis, as well as atopic diseases including type 1 allergies and atopic dermatitis. The prevalence of rheumatoid arthritis, systemic lupus erythematosus, thyroiditis and vitiligo was also increased, as was the prevalence of depression. CU patients who did not have any of the comorbidities at the time of their CU diagnosis had an increased risk of developing both mast cell mediated diseases, atopic diseases, and autoimmune diseases excluding thyroiditis and diabetes.Conclusion: The autoimmune profile of the comorbidities of CU was demonstrated with an evident risk of developing rheumatoid arthritis. CU patients were also at increased risk of either having or achieving depression. Mast cell related diseases seemed to be overrepresented, although registry data within this disease category are questionable and similar to symptoms of CU to the untrained eye. Thus, CU patients constitute a multimorbid group of patients, which must be recognized among treating physicians.

KW - Chronic urticaria

KW - Demographics

KW - Prevalence

KW - Incident risk

KW - Comorbidities

U2 - 10.1016/j.waojou.2019.100097

DO - 10.1016/j.waojou.2019.100097

M3 - Journal article

C2 - 32021661

VL - 13

JO - The World Allergy Organization Journal

JF - The World Allergy Organization Journal

SN - 1939-4551

IS - 1

M1 - 100097

ER -

ID: 236987787