TY - JOUR

T1 - Risk of Atopic Disorders in Patients with Chronic Urticaria

T2 - A Systematic Review and Meta-Analysis

AU - Zhang, Ditte Georgina

AU - Zahid, Jawad Ahmad

AU - Ali, Zarqa

AU - Thomsen, Simon Francis

PY - 2023

Y1 - 2023

N2 - Background: Chronic urticaria (CU) has been associated with several systemic and autoimmune disorders. The association with atopic disorders is however controversial. The objective of this study was to perform a systematic review and meta-analysis to assess the association between CU and the atopic disorders: atopic dermatitis (AD), asthma, and allergic rhinoconjunctivitis (ARC). Methods: Search hits from PubMed, Embase, Cochrane Library, and Web of Science were systematically reviewed. English papers from 2000 to present, containing original data of the association (prevalence, incidence, or risk) between CU and any atopic disorder(s), were included. Pooled point prevalence and OR with 95% confidence intervals were calculated with a random effects model. Results: A total of 8,108 search hits were screened and reviewed. Thirty-eight studies met all inclusion criteria. The estimated pooled point prevalence of AD, asthma, and ARC in CU was 7% (5-11%, I-2 = 99%), 12% (9-15%, I-2 = 100%), and 22% (16-29%, I-2 = 100%), respectively. Pooled ORs were estimated to 2.75 (2.05-3.68, I-2 = 94%) for AD, 1.87 (1.01-3.45, I-2 = 100%) for asthma, and 2.94 (1.84-4.68, I-2 = 100%) for ARC. Conclusion: Pooled point prevalences of atopic disorders in CU were comparable to the general population. However, studies that compared prevalences with controls from the same population all found a significantly increased risk of atopic disorders in CU. Results should however be interpreted with caution as high heterogeneity was found in all analyses. (C) 2022 S. Karger AG, Basel

AB - Background: Chronic urticaria (CU) has been associated with several systemic and autoimmune disorders. The association with atopic disorders is however controversial. The objective of this study was to perform a systematic review and meta-analysis to assess the association between CU and the atopic disorders: atopic dermatitis (AD), asthma, and allergic rhinoconjunctivitis (ARC). Methods: Search hits from PubMed, Embase, Cochrane Library, and Web of Science were systematically reviewed. English papers from 2000 to present, containing original data of the association (prevalence, incidence, or risk) between CU and any atopic disorder(s), were included. Pooled point prevalence and OR with 95% confidence intervals were calculated with a random effects model. Results: A total of 8,108 search hits were screened and reviewed. Thirty-eight studies met all inclusion criteria. The estimated pooled point prevalence of AD, asthma, and ARC in CU was 7% (5-11%, I-2 = 99%), 12% (9-15%, I-2 = 100%), and 22% (16-29%, I-2 = 100%), respectively. Pooled ORs were estimated to 2.75 (2.05-3.68, I-2 = 94%) for AD, 1.87 (1.01-3.45, I-2 = 100%) for asthma, and 2.94 (1.84-4.68, I-2 = 100%) for ARC. Conclusion: Pooled point prevalences of atopic disorders in CU were comparable to the general population. However, studies that compared prevalences with controls from the same population all found a significantly increased risk of atopic disorders in CU. Results should however be interpreted with caution as high heterogeneity was found in all analyses. (C) 2022 S. Karger AG, Basel

KW - Asthma

KW - Atopic disorders

KW - Atopic dermatitis

KW - Chronic urticaria

KW - Rhinoconjunctivitis

KW - CHRONIC IDIOPATHIC URTICARIA

KW - CLINICAL-FEATURES

KW - ALLERGIC RHINITIS

KW - PREVALENCE

KW - ASTHMA

KW - EPIDEMIOLOGY

KW - DERMATITIS

KW - CHILDREN

KW - AUTOANTIBODIES

KW - AUTOIMMUNITY

U2 - 10.1159/000525870

DO - 10.1159/000525870

M3 - Review

C2 - 36044838

VL - 239

SP - 32

EP - 44

JO - Dermatology

JF - Dermatology

SN - 1018-8665

ER -