Reviving lower body negative pressure as a countermeasure to prevent pathological vascular and ocular changes in microgravity

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Reviving lower body negative pressure as a countermeasure to prevent pathological vascular and ocular changes in microgravity. / Harris, Katie M.; Petersen, Lonnie G.; Weber, Tobias.

I: npj Microgravity, Bind 6, Nr. 1, 38, 2020.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Harris, KM, Petersen, LG & Weber, T 2020, 'Reviving lower body negative pressure as a countermeasure to prevent pathological vascular and ocular changes in microgravity', npj Microgravity, bind 6, nr. 1, 38. https://doi.org/10.1038/s41526-020-00127-3

APA

Harris, K. M., Petersen, L. G., & Weber, T. (2020). Reviving lower body negative pressure as a countermeasure to prevent pathological vascular and ocular changes in microgravity. npj Microgravity, 6(1), [38]. https://doi.org/10.1038/s41526-020-00127-3

Vancouver

Harris KM, Petersen LG, Weber T. Reviving lower body negative pressure as a countermeasure to prevent pathological vascular and ocular changes in microgravity. npj Microgravity. 2020;6(1). 38. https://doi.org/10.1038/s41526-020-00127-3

Author

Harris, Katie M. ; Petersen, Lonnie G. ; Weber, Tobias. / Reviving lower body negative pressure as a countermeasure to prevent pathological vascular and ocular changes in microgravity. I: npj Microgravity. 2020 ; Bind 6, Nr. 1.

Bibtex

@article{ea4be397205045ffa30f30c8a80fa956,
title = "Reviving lower body negative pressure as a countermeasure to prevent pathological vascular and ocular changes in microgravity",
abstract = "Mitigation of spaceflight-related pathologies such as spaceflight-associated neuro-ocular syndrome (SANS) and the recently discovered risk of venous thrombosis must happen before deep space exploration can occur. Lower body negative pressure (LBNP) can simulate gravitational stress during spaceflight that is likely to counteract SANS and venous thrombosis, but the ideal dose and method of delivery have yet to be determined. We undertook a review of current LBNP literature and conducted a gap analysis to determine the steps needed to adapt LBNP for in-flight use. We found that to use LBNP in flight, it must be adapted to long time duration/low pressure use that should be compatible with crew activities. A lack of understanding of the etiology of the pathologies that LBNP can counteract hinders the application of LBNP as a countermeasure during spaceflight. Future research should aim at filling the knowledge gaps outlined in this review.",
keywords = "CROSS-SECTIONAL AREA, INTRACRANIAL-PRESSURE, BED REST, ENDOTHELIUM, RESPONSES, FLOW, WEIGHTLESSNESS, SPACEFLIGHT, ADAPTATION, WISE-2005",
author = "Harris, {Katie M.} and Petersen, {Lonnie G.} and Tobias Weber",
year = "2020",
doi = "10.1038/s41526-020-00127-3",
language = "English",
volume = "6",
journal = "npj Microgravity",
issn = "2373-8065",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Reviving lower body negative pressure as a countermeasure to prevent pathological vascular and ocular changes in microgravity

AU - Harris, Katie M.

AU - Petersen, Lonnie G.

AU - Weber, Tobias

PY - 2020

Y1 - 2020

N2 - Mitigation of spaceflight-related pathologies such as spaceflight-associated neuro-ocular syndrome (SANS) and the recently discovered risk of venous thrombosis must happen before deep space exploration can occur. Lower body negative pressure (LBNP) can simulate gravitational stress during spaceflight that is likely to counteract SANS and venous thrombosis, but the ideal dose and method of delivery have yet to be determined. We undertook a review of current LBNP literature and conducted a gap analysis to determine the steps needed to adapt LBNP for in-flight use. We found that to use LBNP in flight, it must be adapted to long time duration/low pressure use that should be compatible with crew activities. A lack of understanding of the etiology of the pathologies that LBNP can counteract hinders the application of LBNP as a countermeasure during spaceflight. Future research should aim at filling the knowledge gaps outlined in this review.

AB - Mitigation of spaceflight-related pathologies such as spaceflight-associated neuro-ocular syndrome (SANS) and the recently discovered risk of venous thrombosis must happen before deep space exploration can occur. Lower body negative pressure (LBNP) can simulate gravitational stress during spaceflight that is likely to counteract SANS and venous thrombosis, but the ideal dose and method of delivery have yet to be determined. We undertook a review of current LBNP literature and conducted a gap analysis to determine the steps needed to adapt LBNP for in-flight use. We found that to use LBNP in flight, it must be adapted to long time duration/low pressure use that should be compatible with crew activities. A lack of understanding of the etiology of the pathologies that LBNP can counteract hinders the application of LBNP as a countermeasure during spaceflight. Future research should aim at filling the knowledge gaps outlined in this review.

KW - CROSS-SECTIONAL AREA

KW - INTRACRANIAL-PRESSURE

KW - BED REST

KW - ENDOTHELIUM

KW - RESPONSES

KW - FLOW

KW - WEIGHTLESSNESS

KW - SPACEFLIGHT

KW - ADAPTATION

KW - WISE-2005

U2 - 10.1038/s41526-020-00127-3

DO - 10.1038/s41526-020-00127-3

M3 - Review

C2 - 33335101

VL - 6

JO - npj Microgravity

JF - npj Microgravity

SN - 2373-8065

IS - 1

M1 - 38

ER -

ID: 256944325