Repolarization Effects of sertindole manifest as T-wave flatness on the ECG

Publikation: Bidrag til tidsskrift › Konferenceartikel › Forskning › fagfællebedømt

Standard

Repolarization Effects of sertindole manifest as T-wave flatness on the ECG. / Bhuiyan, Tanveer A.; Graff, Claus; Kanters, Jørgen K.; Nielsen, Jimmi; Struijk, Johannes J.

I: Computing in Cardiology, Bind 41, 7043059, 01.01.2014, s. 381-384.

Publikation: Bidrag til tidsskrift › Konferenceartikel › Forskning › fagfællebedømt

Harvard

Bhuiyan, TA, Graff, C, Kanters, JK, Nielsen, J & Struijk, JJ 2014, 'Repolarization Effects of sertindole manifest as T-wave flatness on the ECG', Computing in Cardiology, bind 41, 7043059, s. 381-384.

APA

Bhuiyan, T. A., Graff, C., Kanters, J. K., Nielsen, J., & Struijk, J. J. (2014). Repolarization Effects of sertindole manifest as T-wave flatness on the ECG. Computing in Cardiology, 41, 381-384. [7043059].

Vancouver

Bhuiyan TA, Graff C, Kanters JK, Nielsen J, Struijk JJ. Repolarization Effects of sertindole manifest as T-wave flatness on the ECG. Computing in Cardiology. 2014 jan. 1;41:381-384. 7043059.

Author

Bhuiyan, Tanveer A. ; Graff, Claus ; Kanters, Jørgen K. ; Nielsen, Jimmi ; Struijk, Johannes J. / Repolarization Effects of sertindole manifest as T-wave flatness on the ECG. I: Computing in Cardiology. 2014 ; Bind 41. s. 381-384.

Bibtex

@inproceedings{98e60817a8ca43c2835d2c1b0494308b,
title = "Repolarization Effects of sertindole manifest as T-wave flatness on the ECG",
abstract = "Flattening of the electrocardiographic T-wave has been associated with proarrhythmic risk. It has also been demonstrated that triangulation of the monophasic action potential (MAP) manifests on the ECG as a flattened Twave. In this study we investigate the effects of sertindole on the electrocardiographic T-wave using a recently developed ECG marker of T-wave flatness which is directly correlated with sertindole-induced triangulation of the MAP prior to Torsade de Pointes arrhythmia in dogs. The effect of sertindole on T-wave flatness was compared with the effects of moxifloxacin and placebo on the T-wave. Sertindole caused more flattening of the T-wave compared to moxifloxacin and placebo. Effect sizes also revealed that flattening of the T-wave after sertindole was a more prominent finding compared to QT interval prolongation. An electrocardiographic measurement linking MAP triangulation and T-wave flatness could potentially be used for cardiac safety assessment in drug trials along with other safety measures.",
author = "Bhuiyan, {Tanveer A.} and Claus Graff and Kanters, {J{\o}rgen K.} and Jimmi Nielsen and Struijk, {Johannes J.}",
year = "2014",
month = jan,
day = "1",
language = "English",
volume = "41",
pages = "381--384",
journal = "Computing in Cardiology",
issn = "0276-6574",
publisher = "IEEE Computer Society Press",
note = "41st Computing in Cardiology Conference, CinC 2014 ; Conference date: 07-09-2014 Through 10-09-2014",

}

RIS

TY - GEN

T1 - Repolarization Effects of sertindole manifest as T-wave flatness on the ECG

AU - Bhuiyan, Tanveer A.

AU - Graff, Claus

AU - Kanters, Jørgen K.

AU - Nielsen, Jimmi

AU - Struijk, Johannes J.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Flattening of the electrocardiographic T-wave has been associated with proarrhythmic risk. It has also been demonstrated that triangulation of the monophasic action potential (MAP) manifests on the ECG as a flattened Twave. In this study we investigate the effects of sertindole on the electrocardiographic T-wave using a recently developed ECG marker of T-wave flatness which is directly correlated with sertindole-induced triangulation of the MAP prior to Torsade de Pointes arrhythmia in dogs. The effect of sertindole on T-wave flatness was compared with the effects of moxifloxacin and placebo on the T-wave. Sertindole caused more flattening of the T-wave compared to moxifloxacin and placebo. Effect sizes also revealed that flattening of the T-wave after sertindole was a more prominent finding compared to QT interval prolongation. An electrocardiographic measurement linking MAP triangulation and T-wave flatness could potentially be used for cardiac safety assessment in drug trials along with other safety measures.

AB - Flattening of the electrocardiographic T-wave has been associated with proarrhythmic risk. It has also been demonstrated that triangulation of the monophasic action potential (MAP) manifests on the ECG as a flattened Twave. In this study we investigate the effects of sertindole on the electrocardiographic T-wave using a recently developed ECG marker of T-wave flatness which is directly correlated with sertindole-induced triangulation of the MAP prior to Torsade de Pointes arrhythmia in dogs. The effect of sertindole on T-wave flatness was compared with the effects of moxifloxacin and placebo on the T-wave. Sertindole caused more flattening of the T-wave compared to moxifloxacin and placebo. Effect sizes also revealed that flattening of the T-wave after sertindole was a more prominent finding compared to QT interval prolongation. An electrocardiographic measurement linking MAP triangulation and T-wave flatness could potentially be used for cardiac safety assessment in drug trials along with other safety measures.

UR - http://www.scopus.com/inward/record.url?scp=84931458196&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:84931458196

VL - 41

SP - 381

EP - 384

JO - Computing in Cardiology

JF - Computing in Cardiology

SN - 0276-6574

M1 - 7043059

T2 - 41st Computing in Cardiology Conference, CinC 2014

Y2 - 7 September 2014 through 10 September 2014

ER -

ID: 204298963