Proteomics reveals the effects of sustained weight loss on the human plasma proteome

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Standard

Proteomics reveals the effects of sustained weight loss on the human plasma proteome. / Geyer, Philipp E; Wewer Albrechtsen, Nicolai J; Tyanova, Stefka; Grassl, Niklas; Iepsen, Eva Pers Winning; Lundgren, Julie; Madsbad, Sten; Holst, Jens J; Torekov, Signe S; Mann, Matthias.

I: Molecular Systems Biology, Bind 12, 901, 22.12.2016.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Geyer, PE, Wewer Albrechtsen, NJ, Tyanova, S, Grassl, N, Iepsen, EPW, Lundgren, J, Madsbad, S, Holst, JJ, Torekov, SS & Mann, M 2016, 'Proteomics reveals the effects of sustained weight loss on the human plasma proteome', Molecular Systems Biology, bind 12, 901. https://doi.org/10.15252/msb.20167357

APA

Geyer, P. E., Wewer Albrechtsen, N. J., Tyanova, S., Grassl, N., Iepsen, E. P. W., Lundgren, J., ... Mann, M. (2016). Proteomics reveals the effects of sustained weight loss on the human plasma proteome. Molecular Systems Biology, 12, [901]. https://doi.org/10.15252/msb.20167357

Vancouver

Geyer PE, Wewer Albrechtsen NJ, Tyanova S, Grassl N, Iepsen EPW, Lundgren J o.a. Proteomics reveals the effects of sustained weight loss on the human plasma proteome. Molecular Systems Biology. 2016 dec 22;12. 901. https://doi.org/10.15252/msb.20167357

Author

Geyer, Philipp E ; Wewer Albrechtsen, Nicolai J ; Tyanova, Stefka ; Grassl, Niklas ; Iepsen, Eva Pers Winning ; Lundgren, Julie ; Madsbad, Sten ; Holst, Jens J ; Torekov, Signe S ; Mann, Matthias. / Proteomics reveals the effects of sustained weight loss on the human plasma proteome. I: Molecular Systems Biology. 2016 ; Bind 12.

Bibtex

@article{d176ebd524644a66abe882679ca60631,
title = "Proteomics reveals the effects of sustained weight loss on the human plasma proteome",
abstract = "Sustained weight loss is a preferred intervention in a wide range of metabolic conditions, but the effects on an individual's health state remain ill-defined. Here, we investigate the plasma proteomes of a cohort of 43 obese individuals that had undergone 8 weeks of 12{\%} body weight loss followed by a year of weight maintenance. Using mass spectrometry-based plasma proteome profiling, we measured 1,294 plasma proteomes. Longitudinal monitoring of the cohort revealed individual-specific protein levels with wide-ranging effects of losing weight on the plasma proteome reflected in 93 significantly affected proteins. The adipocyte-secreted SERPINF1 and apolipoprotein APOF1 were most significantly regulated with fold changes of -16{\%} and +37{\%}, respectively (P < 10(-13)), and the entire apolipoprotein family showed characteristic differential regulation. Clinical laboratory parameters are reflected in the plasma proteome, and eight plasma proteins correlated better with insulin resistance than the known marker adiponectin. Nearly all study participants benefited from weight loss regarding a ten-protein inflammation panel defined from the proteomics data. We conclude that plasma proteome profiling broadly evaluates and monitors intervention in metabolic diseases.",
author = "Geyer, {Philipp E} and {Wewer Albrechtsen}, {Nicolai J} and Stefka Tyanova and Niklas Grassl and Iepsen, {Eva Pers Winning} and Julie Lundgren and Sten Madsbad and Holst, {Jens J} and Torekov, {Signe S} and Matthias Mann",
note = "{\circledC} 2016 The Authors. Published under the terms of the CC BY 4.0 license.",
year = "2016",
month = "12",
day = "22",
doi = "10.15252/msb.20167357",
language = "English",
volume = "12",
journal = "Molecular Systems Biology",
issn = "1744-4292",
publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - Proteomics reveals the effects of sustained weight loss on the human plasma proteome

AU - Geyer, Philipp E

AU - Wewer Albrechtsen, Nicolai J

AU - Tyanova, Stefka

AU - Grassl, Niklas

AU - Iepsen, Eva Pers Winning

AU - Lundgren, Julie

AU - Madsbad, Sten

AU - Holst, Jens J

AU - Torekov, Signe S

AU - Mann, Matthias

N1 - © 2016 The Authors. Published under the terms of the CC BY 4.0 license.

PY - 2016/12/22

Y1 - 2016/12/22

N2 - Sustained weight loss is a preferred intervention in a wide range of metabolic conditions, but the effects on an individual's health state remain ill-defined. Here, we investigate the plasma proteomes of a cohort of 43 obese individuals that had undergone 8 weeks of 12% body weight loss followed by a year of weight maintenance. Using mass spectrometry-based plasma proteome profiling, we measured 1,294 plasma proteomes. Longitudinal monitoring of the cohort revealed individual-specific protein levels with wide-ranging effects of losing weight on the plasma proteome reflected in 93 significantly affected proteins. The adipocyte-secreted SERPINF1 and apolipoprotein APOF1 were most significantly regulated with fold changes of -16% and +37%, respectively (P < 10(-13)), and the entire apolipoprotein family showed characteristic differential regulation. Clinical laboratory parameters are reflected in the plasma proteome, and eight plasma proteins correlated better with insulin resistance than the known marker adiponectin. Nearly all study participants benefited from weight loss regarding a ten-protein inflammation panel defined from the proteomics data. We conclude that plasma proteome profiling broadly evaluates and monitors intervention in metabolic diseases.

AB - Sustained weight loss is a preferred intervention in a wide range of metabolic conditions, but the effects on an individual's health state remain ill-defined. Here, we investigate the plasma proteomes of a cohort of 43 obese individuals that had undergone 8 weeks of 12% body weight loss followed by a year of weight maintenance. Using mass spectrometry-based plasma proteome profiling, we measured 1,294 plasma proteomes. Longitudinal monitoring of the cohort revealed individual-specific protein levels with wide-ranging effects of losing weight on the plasma proteome reflected in 93 significantly affected proteins. The adipocyte-secreted SERPINF1 and apolipoprotein APOF1 were most significantly regulated with fold changes of -16% and +37%, respectively (P < 10(-13)), and the entire apolipoprotein family showed characteristic differential regulation. Clinical laboratory parameters are reflected in the plasma proteome, and eight plasma proteins correlated better with insulin resistance than the known marker adiponectin. Nearly all study participants benefited from weight loss regarding a ten-protein inflammation panel defined from the proteomics data. We conclude that plasma proteome profiling broadly evaluates and monitors intervention in metabolic diseases.

U2 - 10.15252/msb.20167357

DO - 10.15252/msb.20167357

M3 - Journal article

C2 - 28007936

VL - 12

JO - Molecular Systems Biology

JF - Molecular Systems Biology

SN - 1744-4292

M1 - 901

ER -

ID: 171548599