Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation

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Morten Bækgaard Thomsen, Avram Oros, Marieke Schoenmakers, Jurren M van Opstal, Joep N Maas, Jet D M Beekman, Marc A Vos

Acquired long-QT syndrome in combination with increased beat-to-beat variability of repolarisation duration (BVR) is associated with lethal torsades de pointes arrhythmias (TdP) in dogs with remodelled heart after atrioventricular block (AVB). We evaluated the relative contributions of bradycardia and ventricular remodelling to proarrhythmic BVR with and without pharmacological I(Kr) block in order to identify the individual at risk.
OriginalsprogEngelsk
TidsskriftCardiovascular Research
Vol/bind73
Udgave nummer3
Sider (fra-til)521-30
Antal sider10
ISSN0008-6363
DOI
StatusUdgivet - 1 feb. 2007

ID: 45965525