Preventive effects of kudzu root on bone loss and cartilage degradation in ovariectomized rat

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Preventive effects of kudzu root on bone loss and cartilage degradation in ovariectomized rat. / Luo, Yunyun; Zheng, Shuang; Ding, Yujia; Dai, Yueqin; Zhou, Yi; Xiang, Ruifeng; Bay-Jensen, Anne C; Karsdal, Morten; Qvist, Per; Zheng, Qinlong.

I: American Journal of Translational Research, Bind 9, Nr. 7, 30.07.2017, s. 3517-3527.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Luo, Y, Zheng, S, Ding, Y, Dai, Y, Zhou, Y, Xiang, R, Bay-Jensen, AC, Karsdal, M, Qvist, P & Zheng, Q 2017, 'Preventive effects of kudzu root on bone loss and cartilage degradation in ovariectomized rat', American Journal of Translational Research, bind 9, nr. 7, s. 3517-3527.

APA

Luo, Y., Zheng, S., Ding, Y., Dai, Y., Zhou, Y., Xiang, R., ... Zheng, Q. (2017). Preventive effects of kudzu root on bone loss and cartilage degradation in ovariectomized rat. American Journal of Translational Research, 9(7), 3517-3527.

Vancouver

Luo Y, Zheng S, Ding Y, Dai Y, Zhou Y, Xiang R o.a. Preventive effects of kudzu root on bone loss and cartilage degradation in ovariectomized rat. American Journal of Translational Research. 2017 jul 30;9(7):3517-3527.

Author

Luo, Yunyun ; Zheng, Shuang ; Ding, Yujia ; Dai, Yueqin ; Zhou, Yi ; Xiang, Ruifeng ; Bay-Jensen, Anne C ; Karsdal, Morten ; Qvist, Per ; Zheng, Qinlong. / Preventive effects of kudzu root on bone loss and cartilage degradation in ovariectomized rat. I: American Journal of Translational Research. 2017 ; Bind 9, Nr. 7. s. 3517-3527.

Bibtex

@article{06188a9f8b424dd4851c6e43fc2e17de,
title = "Preventive effects of kudzu root on bone loss and cartilage degradation in ovariectomized rat",
abstract = "The clinical utility of Traditional Chinese Medicine (TCM) herbs/roots extracts in osteoporosis (OP) and osteoarthritis (OA) has been described in multiple reports, but there have been few studies of TCM for preventing bone loss and cartilage degradation simultaneously. Six-month-old female Sprague-Dawley rats each were subjected to ovariectomized (OVX) or sham surgery and treated orally once daily with herbal extracts or vehicle. Body weight was recorded weekly, and blood samples were collected from fasting animals at different time points. Biochemical markers of bone resorption and cartilage degradation were analyzed. Changes in bone mineral density and calcium content were determined in the femoral center and femoral telocentric end of rats. Out of 56 TCM herbs/roots extracts, only kudzu root demonstrated consistent joint protective effects. OVX resulted in a marked increase in bone resorption and cartilage degradation, which could be significantly reversed by kudzu after three weeks of treatment. Compared to vehicle, kudzu induced a significant increase in bone mineral density in the femoral center and femoral telocentric end, and calcium content. The results show that kudzu exerts direct effects on articular cartilage in the OVX rat and can effectively prevent the acceleration of cartilage degradation induced by ovariectomy. Moreover, kudzu has demonstrated positive effects on metabolic health (cause a weight reduction) and may represent a possible treatment for OP and OA with high body mass index. Further studies are needed to investigate the potential effects of kudzu root in postmenopausal women. Preventive effects of kudzu root on bone loss and cartilage degradation in ovariectomized rat. Available from: https://www.researchgate.net/publication/318429071_Preventive_effects_of_kudzu_root_on_bone_loss_and_cartilage_degradation_in_ovariectomized_rat [accessed Sep 7, 2017].",
keywords = "Faculty of Health and Medical Sciences",
author = "Yunyun Luo and Shuang Zheng and Yujia Ding and Yueqin Dai and Yi Zhou and Ruifeng Xiang and Bay-Jensen, {Anne C} and Morten Karsdal and Per Qvist and Qinlong Zheng",
year = "2017",
month = "7",
day = "30",
language = "English",
volume = "9",
pages = "3517--3527",
journal = "American Journal of Translational Research",
issn = "1943-8141",
publisher = "e-Century Publishing Corporation",
number = "7",

}

RIS

TY - JOUR

T1 - Preventive effects of kudzu root on bone loss and cartilage degradation in ovariectomized rat

AU - Luo, Yunyun

AU - Zheng, Shuang

AU - Ding, Yujia

AU - Dai, Yueqin

AU - Zhou, Yi

AU - Xiang, Ruifeng

AU - Bay-Jensen, Anne C

AU - Karsdal, Morten

AU - Qvist, Per

AU - Zheng, Qinlong

PY - 2017/7/30

Y1 - 2017/7/30

N2 - The clinical utility of Traditional Chinese Medicine (TCM) herbs/roots extracts in osteoporosis (OP) and osteoarthritis (OA) has been described in multiple reports, but there have been few studies of TCM for preventing bone loss and cartilage degradation simultaneously. Six-month-old female Sprague-Dawley rats each were subjected to ovariectomized (OVX) or sham surgery and treated orally once daily with herbal extracts or vehicle. Body weight was recorded weekly, and blood samples were collected from fasting animals at different time points. Biochemical markers of bone resorption and cartilage degradation were analyzed. Changes in bone mineral density and calcium content were determined in the femoral center and femoral telocentric end of rats. Out of 56 TCM herbs/roots extracts, only kudzu root demonstrated consistent joint protective effects. OVX resulted in a marked increase in bone resorption and cartilage degradation, which could be significantly reversed by kudzu after three weeks of treatment. Compared to vehicle, kudzu induced a significant increase in bone mineral density in the femoral center and femoral telocentric end, and calcium content. The results show that kudzu exerts direct effects on articular cartilage in the OVX rat and can effectively prevent the acceleration of cartilage degradation induced by ovariectomy. Moreover, kudzu has demonstrated positive effects on metabolic health (cause a weight reduction) and may represent a possible treatment for OP and OA with high body mass index. Further studies are needed to investigate the potential effects of kudzu root in postmenopausal women. Preventive effects of kudzu root on bone loss and cartilage degradation in ovariectomized rat. Available from: https://www.researchgate.net/publication/318429071_Preventive_effects_of_kudzu_root_on_bone_loss_and_cartilage_degradation_in_ovariectomized_rat [accessed Sep 7, 2017].

AB - The clinical utility of Traditional Chinese Medicine (TCM) herbs/roots extracts in osteoporosis (OP) and osteoarthritis (OA) has been described in multiple reports, but there have been few studies of TCM for preventing bone loss and cartilage degradation simultaneously. Six-month-old female Sprague-Dawley rats each were subjected to ovariectomized (OVX) or sham surgery and treated orally once daily with herbal extracts or vehicle. Body weight was recorded weekly, and blood samples were collected from fasting animals at different time points. Biochemical markers of bone resorption and cartilage degradation were analyzed. Changes in bone mineral density and calcium content were determined in the femoral center and femoral telocentric end of rats. Out of 56 TCM herbs/roots extracts, only kudzu root demonstrated consistent joint protective effects. OVX resulted in a marked increase in bone resorption and cartilage degradation, which could be significantly reversed by kudzu after three weeks of treatment. Compared to vehicle, kudzu induced a significant increase in bone mineral density in the femoral center and femoral telocentric end, and calcium content. The results show that kudzu exerts direct effects on articular cartilage in the OVX rat and can effectively prevent the acceleration of cartilage degradation induced by ovariectomy. Moreover, kudzu has demonstrated positive effects on metabolic health (cause a weight reduction) and may represent a possible treatment for OP and OA with high body mass index. Further studies are needed to investigate the potential effects of kudzu root in postmenopausal women. Preventive effects of kudzu root on bone loss and cartilage degradation in ovariectomized rat. Available from: https://www.researchgate.net/publication/318429071_Preventive_effects_of_kudzu_root_on_bone_loss_and_cartilage_degradation_in_ovariectomized_rat [accessed Sep 7, 2017].

KW - Faculty of Health and Medical Sciences

M3 - Journal article

VL - 9

SP - 3517

EP - 3527

JO - American Journal of Translational Research

JF - American Journal of Translational Research

SN - 1943-8141

IS - 7

ER -

ID: 182972737