Prenatal prochloraz treatment significantly increases pregnancy length and reduces offspring weight but does not affect social-olfactory memory in rats

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Prenatal prochloraz treatment significantly increases pregnancy length and reduces offspring weight but does not affect social-olfactory memory in rats. / Dmytriyeva, Oksana; Klementiev, Boris; Berezin, Vladimir; Bock, Elisabeth.

I: Experimental and Toxicologic Pathology, Bind 65, Nr. 5, 2013, s. 591–593.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Dmytriyeva, O, Klementiev, B, Berezin, V & Bock, E 2013, 'Prenatal prochloraz treatment significantly increases pregnancy length and reduces offspring weight but does not affect social-olfactory memory in rats', Experimental and Toxicologic Pathology, bind 65, nr. 5, s. 591–593. https://doi.org/10.1016/j.etp.2012.06.001

APA

Dmytriyeva, O., Klementiev, B., Berezin, V., & Bock, E. (2013). Prenatal prochloraz treatment significantly increases pregnancy length and reduces offspring weight but does not affect social-olfactory memory in rats. Experimental and Toxicologic Pathology, 65(5), 591–593. https://doi.org/10.1016/j.etp.2012.06.001

Vancouver

Dmytriyeva O, Klementiev B, Berezin V, Bock E. Prenatal prochloraz treatment significantly increases pregnancy length and reduces offspring weight but does not affect social-olfactory memory in rats. Experimental and Toxicologic Pathology. 2013;65(5):591–593. https://doi.org/10.1016/j.etp.2012.06.001

Author

Dmytriyeva, Oksana ; Klementiev, Boris ; Berezin, Vladimir ; Bock, Elisabeth. / Prenatal prochloraz treatment significantly increases pregnancy length and reduces offspring weight but does not affect social-olfactory memory in rats. I: Experimental and Toxicologic Pathology. 2013 ; Bind 65, Nr. 5. s. 591–593.

Bibtex

@article{a6ad59c8c7de4c8ba4f846581fc22d6c,
title = "Prenatal prochloraz treatment significantly increases pregnancy length and reduces offspring weight but does not affect social-olfactory memory in rats",
abstract = "Metabolites of the commonly used imidazole fungicide prochloraz are androgen receptor antagonists. They have been shown to block androgen-driven development and compromise reproductive function. We tested the effect of prochloraz on cognitive behavior following exposure to this fungicide during the perinatal period. Pregnant Wistar rats were administered a 200mg/kg dose of prochloraz on gestational day (GD) 7, GD11, and GD15. The social recognition test (SRT) was performed on 7-week-old male rat offspring. We found an increase in pregnancy length and a significantly reduced pup weight on PND15 and PND40 but no effect of prenatal prochloraz exposure on social investigation or acquisition of social-olfactory memory.",
author = "Oksana Dmytriyeva and Boris Klementiev and Vladimir Berezin and Elisabeth Bock",
note = "Copyright {\textcopyright} 2012. Published by Elsevier GmbH.",
year = "2013",
doi = "10.1016/j.etp.2012.06.001",
language = "English",
volume = "65",
pages = "591–593",
journal = "Experimental and Toxicologic Pathology",
issn = "0940-2993",
publisher = "Elsevier GmbH - Urban und Fischer",
number = "5",

}

RIS

TY - JOUR

T1 - Prenatal prochloraz treatment significantly increases pregnancy length and reduces offspring weight but does not affect social-olfactory memory in rats

AU - Dmytriyeva, Oksana

AU - Klementiev, Boris

AU - Berezin, Vladimir

AU - Bock, Elisabeth

N1 - Copyright © 2012. Published by Elsevier GmbH.

PY - 2013

Y1 - 2013

N2 - Metabolites of the commonly used imidazole fungicide prochloraz are androgen receptor antagonists. They have been shown to block androgen-driven development and compromise reproductive function. We tested the effect of prochloraz on cognitive behavior following exposure to this fungicide during the perinatal period. Pregnant Wistar rats were administered a 200mg/kg dose of prochloraz on gestational day (GD) 7, GD11, and GD15. The social recognition test (SRT) was performed on 7-week-old male rat offspring. We found an increase in pregnancy length and a significantly reduced pup weight on PND15 and PND40 but no effect of prenatal prochloraz exposure on social investigation or acquisition of social-olfactory memory.

AB - Metabolites of the commonly used imidazole fungicide prochloraz are androgen receptor antagonists. They have been shown to block androgen-driven development and compromise reproductive function. We tested the effect of prochloraz on cognitive behavior following exposure to this fungicide during the perinatal period. Pregnant Wistar rats were administered a 200mg/kg dose of prochloraz on gestational day (GD) 7, GD11, and GD15. The social recognition test (SRT) was performed on 7-week-old male rat offspring. We found an increase in pregnancy length and a significantly reduced pup weight on PND15 and PND40 but no effect of prenatal prochloraz exposure on social investigation or acquisition of social-olfactory memory.

U2 - 10.1016/j.etp.2012.06.001

DO - 10.1016/j.etp.2012.06.001

M3 - Journal article

C2 - 22727564

VL - 65

SP - 591

EP - 593

JO - Experimental and Toxicologic Pathology

JF - Experimental and Toxicologic Pathology

SN - 0940-2993

IS - 5

ER -

ID: 45118210