Pouzolzia floresiana Friis & Wilmot-Dear (Urticaceae) is described and illustrated on the basis of a single collection from the western part of the Indonesian island of Flores. The species is a thick-stemmed herb, similar in habit to Pouzolzia thailandica, but differs in having axillary flower clusters and broadly winged fruiting perianths. The description of the new species supplements a revision of the Old World taxa of Pouzolzia by the two authors published in 2006.