Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery. / Wewer Albrechtsen, Nicolai J; Geyer, Philipp E; Doll, Sophia; Treit, Peter V; Bojsen-Møller, Kirstine N; Martinussen, Christoffer; Jørgensen, Nils B; Torekov, Signe S; Meier, Florian; Niu, Lili; Santos, Alberto; Keilhauer, Eva C; Holst, Jens J; Madsbad, Sten; Mann, Matthias.

I: Cell Systems, Bind 7, Nr. 6, 2018, s. 601-612.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Wewer Albrechtsen, NJ, Geyer, PE, Doll, S, Treit, PV, Bojsen-Møller, KN, Martinussen, C, Jørgensen, NB, Torekov, SS, Meier, F, Niu, L, Santos, A, Keilhauer, EC, Holst, JJ, Madsbad, S & Mann, M 2018, 'Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery', Cell Systems, bind 7, nr. 6, s. 601-612. https://doi.org/10.1016/j.cels.2018.10.012

APA

Wewer Albrechtsen, N. J., Geyer, P. E., Doll, S., Treit, P. V., Bojsen-Møller, K. N., Martinussen, C., Jørgensen, N. B., Torekov, S. S., Meier, F., Niu, L., Santos, A., Keilhauer, E. C., Holst, J. J., Madsbad, S., & Mann, M. (2018). Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery. Cell Systems, 7(6), 601-612. https://doi.org/10.1016/j.cels.2018.10.012

Vancouver

Wewer Albrechtsen NJ, Geyer PE, Doll S, Treit PV, Bojsen-Møller KN, Martinussen C o.a. Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery. Cell Systems. 2018;7(6):601-612. https://doi.org/10.1016/j.cels.2018.10.012

Author

Wewer Albrechtsen, Nicolai J ; Geyer, Philipp E ; Doll, Sophia ; Treit, Peter V ; Bojsen-Møller, Kirstine N ; Martinussen, Christoffer ; Jørgensen, Nils B ; Torekov, Signe S ; Meier, Florian ; Niu, Lili ; Santos, Alberto ; Keilhauer, Eva C ; Holst, Jens J ; Madsbad, Sten ; Mann, Matthias. / Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery. I: Cell Systems. 2018 ; Bind 7, Nr. 6. s. 601-612.

Bibtex

@article{6445e470eef1450381f8510861746fbb,
title = "Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery",
abstract = "Obesity-related diseases affect half of the global population, and bariatric surgery is one of the few interventions with long-lasting weight loss and cardio-metabolic effects. Here, we investigated the effect of Roux-en-Y gastric bypass surgery on the plasma proteome, hypothesizing that specific proteins or protein patterns may serve as key mediators and markers of the metabolic response. We performed mass spectrometry (MS)-based proteomics on two longitudinal studies encompassing 47 morbidly obese patients, generating quantitative information on more than 1,700 proteins. A global correlation matrix incorporating about 200,000 relationships revealed functional connections between proteins and assigned them to physiological processes. The main classes of significantly altered proteins were markers of systemic inflammation and those involved in lipid metabolism. Our data highlight robust correlative and anti-correlative behaviors of circulating proteins to each other and to clinical parameters. A group of inflammation-related proteins showed distinct inverse relationships to proteins consistently associated with insulin sensitivity.",
author = "{Wewer Albrechtsen}, {Nicolai J} and Geyer, {Philipp E} and Sophia Doll and Treit, {Peter V} and Bojsen-M{\o}ller, {Kirstine N} and Christoffer Martinussen and J{\o}rgensen, {Nils B} and Torekov, {Signe S} and Florian Meier and Lili Niu and Alberto Santos and Keilhauer, {Eva C} and Holst, {Jens J} and Sten Madsbad and Matthias Mann",
note = "Copyright {\textcopyright} 2018 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2018",
doi = "10.1016/j.cels.2018.10.012",
language = "English",
volume = "7",
pages = "601--612",
journal = "Cell Systems",
issn = "2405-4712",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery

AU - Wewer Albrechtsen, Nicolai J

AU - Geyer, Philipp E

AU - Doll, Sophia

AU - Treit, Peter V

AU - Bojsen-Møller, Kirstine N

AU - Martinussen, Christoffer

AU - Jørgensen, Nils B

AU - Torekov, Signe S

AU - Meier, Florian

AU - Niu, Lili

AU - Santos, Alberto

AU - Keilhauer, Eva C

AU - Holst, Jens J

AU - Madsbad, Sten

AU - Mann, Matthias

N1 - Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2018

Y1 - 2018

N2 - Obesity-related diseases affect half of the global population, and bariatric surgery is one of the few interventions with long-lasting weight loss and cardio-metabolic effects. Here, we investigated the effect of Roux-en-Y gastric bypass surgery on the plasma proteome, hypothesizing that specific proteins or protein patterns may serve as key mediators and markers of the metabolic response. We performed mass spectrometry (MS)-based proteomics on two longitudinal studies encompassing 47 morbidly obese patients, generating quantitative information on more than 1,700 proteins. A global correlation matrix incorporating about 200,000 relationships revealed functional connections between proteins and assigned them to physiological processes. The main classes of significantly altered proteins were markers of systemic inflammation and those involved in lipid metabolism. Our data highlight robust correlative and anti-correlative behaviors of circulating proteins to each other and to clinical parameters. A group of inflammation-related proteins showed distinct inverse relationships to proteins consistently associated with insulin sensitivity.

AB - Obesity-related diseases affect half of the global population, and bariatric surgery is one of the few interventions with long-lasting weight loss and cardio-metabolic effects. Here, we investigated the effect of Roux-en-Y gastric bypass surgery on the plasma proteome, hypothesizing that specific proteins or protein patterns may serve as key mediators and markers of the metabolic response. We performed mass spectrometry (MS)-based proteomics on two longitudinal studies encompassing 47 morbidly obese patients, generating quantitative information on more than 1,700 proteins. A global correlation matrix incorporating about 200,000 relationships revealed functional connections between proteins and assigned them to physiological processes. The main classes of significantly altered proteins were markers of systemic inflammation and those involved in lipid metabolism. Our data highlight robust correlative and anti-correlative behaviors of circulating proteins to each other and to clinical parameters. A group of inflammation-related proteins showed distinct inverse relationships to proteins consistently associated with insulin sensitivity.

U2 - 10.1016/j.cels.2018.10.012

DO - 10.1016/j.cels.2018.10.012

M3 - Journal article

C2 - 30528273

VL - 7

SP - 601

EP - 612

JO - Cell Systems

JF - Cell Systems

SN - 2405-4712

IS - 6

ER -

ID: 209832345