Peanut-shaped gold nanoparticles with shells of ceragenin csa-131 display the ability to inhibit ovarian cancer growth in vitro and in a tumor xenograft model
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Peanut-shaped gold nanoparticles with shells of ceragenin csa-131 display the ability to inhibit ovarian cancer growth in vitro and in a tumor xenograft model. / Piktel, Ewelina; Oscilowska, Ilona; Suprewicz, Łukasz; Depciuch, Joanna; Marcińczyk, Natalia; Chabielska, Ewa; Wolak, Przemysław; Głuszek, Katarzyna; Klimek, Justyna; Zieliński, Piotr M.; Marzec, Michał T.; Savage, Paul B.; Parlińska-Wojtan, Magdalena; Bucki, Robert.
I: Cancers, Bind 13, Nr. 21, 5424, 2021, s. 1-26.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Peanut-shaped gold nanoparticles with shells of ceragenin csa-131 display the ability to inhibit ovarian cancer growth in vitro and in a tumor xenograft model
AU - Piktel, Ewelina
AU - Oscilowska, Ilona
AU - Suprewicz, Łukasz
AU - Depciuch, Joanna
AU - Marcińczyk, Natalia
AU - Chabielska, Ewa
AU - Wolak, Przemysław
AU - Głuszek, Katarzyna
AU - Klimek, Justyna
AU - Zieliński, Piotr M.
AU - Marzec, Michał T.
AU - Savage, Paul B.
AU - Parlińska-Wojtan, Magdalena
AU - Bucki, Robert
N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021
Y1 - 2021
N2 - Gold nanoparticles-assisted delivery of antineoplastics into cancerous cells is presented as an effective approach for overcoming the limitations of systemic chemotherapy. Although ceragenins show great potential as anti-cancer agents, in some tumors, effective inhibition of cancer cells proliferation requires application of ceragenins at doses within their hemolytic range. For the purpose of toxicity/efficiency ratio control, peanut-shaped gold nanoparticles (AuP NPs) were functionalized with a shell of ceragenin CSA-131 and the cytotoxicity of AuP@CSA-131 against ovarian cancer SKOV-3 cells and were then analyzed. In vivo efficiency of intravenously and intratumorally administered CSA-131 and AuP@CSA-131 was examined using a xenograft ovarian cancer model. Serum parameters were estimated using ELISA methods. Comparative analysis revealed that AuP@CSA-131 exerted stronger anti-cancer effects than free ceragenin, which was determined by enhanced ability to induce caspase-dependent apoptosis and autophagy processes via reactive oxygen species (ROS)-mediated pathways. In an animal study, AuP@CSA-131 was characterized by delayed clearance and prolonged blood circulation when compared with free ceragenin, as well as enhanced anti-tumor efficiency, particularly when applied intratumorally. Administration of CSA-131 and AuP@CSA-131 prevented the inflammatory response associated with cancer development. These results present the possibility of employing non-spherical gold nanoparticles as an effective nanoplatform for the delivery of antineoplastics for the treatment of ovarian malignancy.
AB - Gold nanoparticles-assisted delivery of antineoplastics into cancerous cells is presented as an effective approach for overcoming the limitations of systemic chemotherapy. Although ceragenins show great potential as anti-cancer agents, in some tumors, effective inhibition of cancer cells proliferation requires application of ceragenins at doses within their hemolytic range. For the purpose of toxicity/efficiency ratio control, peanut-shaped gold nanoparticles (AuP NPs) were functionalized with a shell of ceragenin CSA-131 and the cytotoxicity of AuP@CSA-131 against ovarian cancer SKOV-3 cells and were then analyzed. In vivo efficiency of intravenously and intratumorally administered CSA-131 and AuP@CSA-131 was examined using a xenograft ovarian cancer model. Serum parameters were estimated using ELISA methods. Comparative analysis revealed that AuP@CSA-131 exerted stronger anti-cancer effects than free ceragenin, which was determined by enhanced ability to induce caspase-dependent apoptosis and autophagy processes via reactive oxygen species (ROS)-mediated pathways. In an animal study, AuP@CSA-131 was characterized by delayed clearance and prolonged blood circulation when compared with free ceragenin, as well as enhanced anti-tumor efficiency, particularly when applied intratumorally. Administration of CSA-131 and AuP@CSA-131 prevented the inflammatory response associated with cancer development. These results present the possibility of employing non-spherical gold nanoparticles as an effective nanoplatform for the delivery of antineoplastics for the treatment of ovarian malignancy.
KW - Ceragenins
KW - Drug delivery
KW - Gold nanopeanuts
KW - Nanotechnology
KW - Non-spherical gold nanoparticles
KW - Ovarian cancer
UR - http://www.scopus.com/inward/record.url?scp=85118173032&partnerID=8YFLogxK
U2 - 10.3390/cancers13215424
DO - 10.3390/cancers13215424
M3 - Journal article
C2 - 34771587
AN - SCOPUS:85118173032
VL - 13
SP - 1
EP - 26
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 21
M1 - 5424
ER -
ID: 284639988