Parenteral nutrition impairs plasma bile acid and gut hormone responses to mixed meal testing in lean healthy men

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Parenteral nutrition impairs plasma bile acid and gut hormone responses to mixed meal testing in lean healthy men. / Meessen, Emma C.E.; Bakker, Guido J.; Nieuwdorp, Max; Dallinga-Thie, Geesje M.; Kemper, E. Marleen; Olde Damink, Steven W.; Romijn, Johannes A.; Hartmann, Bolette; Holst, Jens J.; Knop, Filip K.; Groen, Albert K.; Schaap, Frank G.; Soeters, Maarten R.

I: Clinical Nutrition, Bind 40, Nr. 3, 2021, s. 1013-1021.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Meessen, ECE, Bakker, GJ, Nieuwdorp, M, Dallinga-Thie, GM, Kemper, EM, Olde Damink, SW, Romijn, JA, Hartmann, B, Holst, JJ, Knop, FK, Groen, AK, Schaap, FG & Soeters, MR 2021, 'Parenteral nutrition impairs plasma bile acid and gut hormone responses to mixed meal testing in lean healthy men', Clinical Nutrition, bind 40, nr. 3, s. 1013-1021. https://doi.org/10.1016/j.clnu.2020.06.032

APA

Meessen, E. C. E., Bakker, G. J., Nieuwdorp, M., Dallinga-Thie, G. M., Kemper, E. M., Olde Damink, S. W., Romijn, J. A., Hartmann, B., Holst, J. J., Knop, F. K., Groen, A. K., Schaap, F. G., & Soeters, M. R. (2021). Parenteral nutrition impairs plasma bile acid and gut hormone responses to mixed meal testing in lean healthy men. Clinical Nutrition, 40(3), 1013-1021. https://doi.org/10.1016/j.clnu.2020.06.032

Vancouver

Meessen ECE, Bakker GJ, Nieuwdorp M, Dallinga-Thie GM, Kemper EM, Olde Damink SW o.a. Parenteral nutrition impairs plasma bile acid and gut hormone responses to mixed meal testing in lean healthy men. Clinical Nutrition. 2021;40(3):1013-1021. https://doi.org/10.1016/j.clnu.2020.06.032

Author

Meessen, Emma C.E. ; Bakker, Guido J. ; Nieuwdorp, Max ; Dallinga-Thie, Geesje M. ; Kemper, E. Marleen ; Olde Damink, Steven W. ; Romijn, Johannes A. ; Hartmann, Bolette ; Holst, Jens J. ; Knop, Filip K. ; Groen, Albert K. ; Schaap, Frank G. ; Soeters, Maarten R. / Parenteral nutrition impairs plasma bile acid and gut hormone responses to mixed meal testing in lean healthy men. I: Clinical Nutrition. 2021 ; Bind 40, Nr. 3. s. 1013-1021.

Bibtex

@article{5dd0fa9e93954d33a28dc0fc4f19caff,
title = "Parenteral nutrition impairs plasma bile acid and gut hormone responses to mixed meal testing in lean healthy men",
abstract = "Background & aims: To investigate the acute effects of intravenous vs enteral meal administration on circulating bile acid and gut hormone responses. Methods: In a randomized crossover design, we compared the effects of duodenal (via a nasoduodenal tube) vs parenteral (intravenous) administration over 180 min of identical mixed meals on circulating bile acid and gut hormone concentrations in eight healthy lean men. We analysed the bile acid and gut hormone responses in two periods: the intraprandial period from time point (T) 0 until T180 during meal administration and the postprandial period from T180 until T360, after discontinuation of meal administration. Results: Intravenous meal administration decreased the intraprandial (AUC (μmol/L∗min) duodenal 1469 ± 284 vs intravenous 240 ± 39, p < 0.01) and postprandial bile acid response (985 ± 240 vs 223 ± 5, p < 0.05) and was accompanied by decreased gut hormone responses including glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, glucagon-like peptide 2 and fibroblast growth factor 19. Furthermore, intravenous meal administration elicited greater glucose concentrations, but similar insulin concentrations compared to enteral administration. Conclusions: Compared to enteral administration, parenteral nutrition results in lower postprandial bile acid and gut hormone responses in healthy lean men. This was accompanied by higher glucose concentrations in the face of similar insulin concentrations exposing a clear incretin effect of enteral mixed meal administration. The alterations in bile acid homeostasis were apparent after only one intravenous meal.",
keywords = "Bile acids, Fibroblast growth factor 19, Glucagon-like peptide 1, Mixed meal test, Parenteral nutrition, Postprandial",
author = "Meessen, {Emma C.E.} and Bakker, {Guido J.} and Max Nieuwdorp and Dallinga-Thie, {Geesje M.} and Kemper, {E. Marleen} and {Olde Damink}, {Steven W.} and Romijn, {Johannes A.} and Bolette Hartmann and Holst, {Jens J.} and Knop, {Filip K.} and Groen, {Albert K.} and Schaap, {Frank G.} and Soeters, {Maarten R.}",
year = "2021",
doi = "10.1016/j.clnu.2020.06.032",
language = "English",
volume = "40",
pages = "1013--1021",
journal = "Clinical Nutrition",
issn = "0261-5614",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Parenteral nutrition impairs plasma bile acid and gut hormone responses to mixed meal testing in lean healthy men

AU - Meessen, Emma C.E.

AU - Bakker, Guido J.

AU - Nieuwdorp, Max

AU - Dallinga-Thie, Geesje M.

AU - Kemper, E. Marleen

AU - Olde Damink, Steven W.

AU - Romijn, Johannes A.

AU - Hartmann, Bolette

AU - Holst, Jens J.

AU - Knop, Filip K.

AU - Groen, Albert K.

AU - Schaap, Frank G.

AU - Soeters, Maarten R.

PY - 2021

Y1 - 2021

N2 - Background & aims: To investigate the acute effects of intravenous vs enteral meal administration on circulating bile acid and gut hormone responses. Methods: In a randomized crossover design, we compared the effects of duodenal (via a nasoduodenal tube) vs parenteral (intravenous) administration over 180 min of identical mixed meals on circulating bile acid and gut hormone concentrations in eight healthy lean men. We analysed the bile acid and gut hormone responses in two periods: the intraprandial period from time point (T) 0 until T180 during meal administration and the postprandial period from T180 until T360, after discontinuation of meal administration. Results: Intravenous meal administration decreased the intraprandial (AUC (μmol/L∗min) duodenal 1469 ± 284 vs intravenous 240 ± 39, p < 0.01) and postprandial bile acid response (985 ± 240 vs 223 ± 5, p < 0.05) and was accompanied by decreased gut hormone responses including glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, glucagon-like peptide 2 and fibroblast growth factor 19. Furthermore, intravenous meal administration elicited greater glucose concentrations, but similar insulin concentrations compared to enteral administration. Conclusions: Compared to enteral administration, parenteral nutrition results in lower postprandial bile acid and gut hormone responses in healthy lean men. This was accompanied by higher glucose concentrations in the face of similar insulin concentrations exposing a clear incretin effect of enteral mixed meal administration. The alterations in bile acid homeostasis were apparent after only one intravenous meal.

AB - Background & aims: To investigate the acute effects of intravenous vs enteral meal administration on circulating bile acid and gut hormone responses. Methods: In a randomized crossover design, we compared the effects of duodenal (via a nasoduodenal tube) vs parenteral (intravenous) administration over 180 min of identical mixed meals on circulating bile acid and gut hormone concentrations in eight healthy lean men. We analysed the bile acid and gut hormone responses in two periods: the intraprandial period from time point (T) 0 until T180 during meal administration and the postprandial period from T180 until T360, after discontinuation of meal administration. Results: Intravenous meal administration decreased the intraprandial (AUC (μmol/L∗min) duodenal 1469 ± 284 vs intravenous 240 ± 39, p < 0.01) and postprandial bile acid response (985 ± 240 vs 223 ± 5, p < 0.05) and was accompanied by decreased gut hormone responses including glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, glucagon-like peptide 2 and fibroblast growth factor 19. Furthermore, intravenous meal administration elicited greater glucose concentrations, but similar insulin concentrations compared to enteral administration. Conclusions: Compared to enteral administration, parenteral nutrition results in lower postprandial bile acid and gut hormone responses in healthy lean men. This was accompanied by higher glucose concentrations in the face of similar insulin concentrations exposing a clear incretin effect of enteral mixed meal administration. The alterations in bile acid homeostasis were apparent after only one intravenous meal.

KW - Bile acids

KW - Fibroblast growth factor 19

KW - Glucagon-like peptide 1

KW - Mixed meal test

KW - Parenteral nutrition

KW - Postprandial

U2 - 10.1016/j.clnu.2020.06.032

DO - 10.1016/j.clnu.2020.06.032

M3 - Journal article

C2 - 32747206

AN - SCOPUS:85088866584

VL - 40

SP - 1013

EP - 1021

JO - Clinical Nutrition

JF - Clinical Nutrition

SN - 0261-5614

IS - 3

ER -

ID: 251689513