No effect of physiological concentrations of glucagon-like peptide-2 on appetite and energy intake in normal weight subjects

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Standard

No effect of physiological concentrations of glucagon-like peptide-2 on appetite and energy intake in normal weight subjects. / Sørensen, L B; Flint, A; Raben, A; Hartmann, B; Holst, Jens Juul; Astrup, A.

I: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, Bind 27, Nr. 4, 04.2003, s. 450-6.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Sørensen, LB, Flint, A, Raben, A, Hartmann, B, Holst, JJ & Astrup, A 2003, 'No effect of physiological concentrations of glucagon-like peptide-2 on appetite and energy intake in normal weight subjects', International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, bind 27, nr. 4, s. 450-6. https://doi.org/10.1038/sj.ijo.0802247

APA

Sørensen, L. B., Flint, A., Raben, A., Hartmann, B., Holst, J. J., & Astrup, A. (2003). No effect of physiological concentrations of glucagon-like peptide-2 on appetite and energy intake in normal weight subjects. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 27(4), 450-6. https://doi.org/10.1038/sj.ijo.0802247

Vancouver

Sørensen LB, Flint A, Raben A, Hartmann B, Holst JJ, Astrup A. No effect of physiological concentrations of glucagon-like peptide-2 on appetite and energy intake in normal weight subjects. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 2003 apr;27(4):450-6. https://doi.org/10.1038/sj.ijo.0802247

Author

Sørensen, L B ; Flint, A ; Raben, A ; Hartmann, B ; Holst, Jens Juul ; Astrup, A. / No effect of physiological concentrations of glucagon-like peptide-2 on appetite and energy intake in normal weight subjects. I: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 2003 ; Bind 27, Nr. 4. s. 450-6.

Bibtex

@article{c6f7310d6bda4107939ede1cc2bdf30f,
title = "No effect of physiological concentrations of glucagon-like peptide-2 on appetite and energy intake in normal weight subjects",
abstract = "OBJECTIVE: To examine the effect of a GLP-2 infusion on appetite sensations and ad libitum energy intake in healthy, normal weight humans.DESIGN: The experiment was performed in a randomised, blinded, and placebo-controlled crossover design. Placebo or GLP-2 was infused (infusion rate of 25 pmol/kg body wth) for 4.5 h.SUBJECTS: A total of 18 healthy, normal weight young subjects participated; eight women and 10 men.MEASUREMENTS: During the infusion, subjects recorded their appetite sensations every 30 min using visual analogue scales, and blood was sampled frequently. After 2 h of infusion, an ad libitum meal, consisting of sandwiches, was served.RESULTS: The concentration of GLP-2 was significantly higher during the GLP-2 infusion compared with placebo (P<0.0001) and increased further in both conditions in response to the meal. Neither appetite sensations, nor palatability of the test meals, or energy intake were different on the two occasions. Glucose, GLP-1, insulin, and GIP responses were also unaffected by the infusion, whereas glucagon levels were higher during the GLP-2 treatment (P<0.05).CONCLUSION: Circulating GLP-2 in physiological concentrations does not seem to play a significant role in human appetite regulation.",
keywords = "Adult, Appetite, Cross-Over Studies, Double-Blind Method, Energy Intake, Feeding Behavior, Female, Glucagon-Like Peptide 1, Glucagon-Like Peptide 2, Humans, Male, Peptides, Postprandial Period, Satiation",
author = "S{\o}rensen, {L B} and A Flint and A Raben and B Hartmann and Holst, {Jens Juul} and A Astrup",
year = "2003",
month = "4",
doi = "10.1038/sj.ijo.0802247",
language = "English",
volume = "27",
pages = "450--6",
journal = "International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity",
number = "4",

}

RIS

TY - JOUR

T1 - No effect of physiological concentrations of glucagon-like peptide-2 on appetite and energy intake in normal weight subjects

AU - Sørensen, L B

AU - Flint, A

AU - Raben, A

AU - Hartmann, B

AU - Holst, Jens Juul

AU - Astrup, A

PY - 2003/4

Y1 - 2003/4

N2 - OBJECTIVE: To examine the effect of a GLP-2 infusion on appetite sensations and ad libitum energy intake in healthy, normal weight humans.DESIGN: The experiment was performed in a randomised, blinded, and placebo-controlled crossover design. Placebo or GLP-2 was infused (infusion rate of 25 pmol/kg body wth) for 4.5 h.SUBJECTS: A total of 18 healthy, normal weight young subjects participated; eight women and 10 men.MEASUREMENTS: During the infusion, subjects recorded their appetite sensations every 30 min using visual analogue scales, and blood was sampled frequently. After 2 h of infusion, an ad libitum meal, consisting of sandwiches, was served.RESULTS: The concentration of GLP-2 was significantly higher during the GLP-2 infusion compared with placebo (P<0.0001) and increased further in both conditions in response to the meal. Neither appetite sensations, nor palatability of the test meals, or energy intake were different on the two occasions. Glucose, GLP-1, insulin, and GIP responses were also unaffected by the infusion, whereas glucagon levels were higher during the GLP-2 treatment (P<0.05).CONCLUSION: Circulating GLP-2 in physiological concentrations does not seem to play a significant role in human appetite regulation.

AB - OBJECTIVE: To examine the effect of a GLP-2 infusion on appetite sensations and ad libitum energy intake in healthy, normal weight humans.DESIGN: The experiment was performed in a randomised, blinded, and placebo-controlled crossover design. Placebo or GLP-2 was infused (infusion rate of 25 pmol/kg body wth) for 4.5 h.SUBJECTS: A total of 18 healthy, normal weight young subjects participated; eight women and 10 men.MEASUREMENTS: During the infusion, subjects recorded their appetite sensations every 30 min using visual analogue scales, and blood was sampled frequently. After 2 h of infusion, an ad libitum meal, consisting of sandwiches, was served.RESULTS: The concentration of GLP-2 was significantly higher during the GLP-2 infusion compared with placebo (P<0.0001) and increased further in both conditions in response to the meal. Neither appetite sensations, nor palatability of the test meals, or energy intake were different on the two occasions. Glucose, GLP-1, insulin, and GIP responses were also unaffected by the infusion, whereas glucagon levels were higher during the GLP-2 treatment (P<0.05).CONCLUSION: Circulating GLP-2 in physiological concentrations does not seem to play a significant role in human appetite regulation.

KW - Adult

KW - Appetite

KW - Cross-Over Studies

KW - Double-Blind Method

KW - Energy Intake

KW - Feeding Behavior

KW - Female

KW - Glucagon-Like Peptide 1

KW - Glucagon-Like Peptide 2

KW - Humans

KW - Male

KW - Peptides

KW - Postprandial Period

KW - Satiation

U2 - 10.1038/sj.ijo.0802247

DO - 10.1038/sj.ijo.0802247

M3 - Journal article

C2 - 12664078

VL - 27

SP - 450

EP - 456

JO - International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity

JF - International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity

IS - 4

ER -

ID: 132056212