New perspectives on the development of muscle contractures following central motor lesions

Publikation: Bidrag til tidsskriftReviewfagfællebedømt

Muscle contractures are common in patients with central motor lesions, but the mechanisms responsible for the development of contractures are still unclear. Increased or decreased neural activation, protracted placement of a joint with the muscle in a short position and muscle atrophy have been suggested to be involved, but none of these mechanisms are sufficient to explain the development of muscle contractures alone. Here we propose that changes in tissue homeostasis in the neuro-muscular-tendon-connective tissue complex is at the heart of the development of contractures, and that an integrated physiological understanding of the interaction between neural, mechanical and metabolic factors, as well as genetic and epigenetic factors, is necessary in order to unravel the mechanisms that result in muscle contractures. We hope thereby to contribute to a reconsideration of how and why muscle contractures develop in a way which will open a window towards new insight in this area in the future. This article is protected by copyright. All rights reserved.

OriginalsprogEngelsk
TidsskriftJournal of Physiology
Vol/bind595
Udgave nummer4
Sider (fra-til)1027-1038
Antal sider12
ISSN0022-3751
DOI
StatusUdgivet - 2017

Bibliografisk note

CURIS 2017 NEXS 055

ID: 167914996