[New marker in thrombotic thrombocytopenic purpura]

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

A. Hillarp, A. Lindblom, P. Bjork, K. Strandberg, L.B. Nielsen, Jens Peter Gøtze

Thrombotic microangiopathy can be caused by several conditions which are difficult to diagnose from the clinical presentation alone. Deficient enzyme activity of a newly-discovered enzyme, ADAMTS-13, can lead to thrombotic thrombocytopenic purpura (TTP). Lack of ADAMTS-13 activity causes increased concentrations of high molecular weight von Willebrand factor forms and increased platelet aggregation. Measurement of ADAMTS-13 activity is useful for the diagnosis of TTP and may also be relevant as a prognostic test for recurrent TTP
Udgivelsesdato: 2008/8/11
OriginalsprogDansk
TidsskriftUgeskrift for læger
Vol/bind170
Udgave nummer33
Sider (fra-til)2446-2449
Antal sider3
ISSN0041-5782
StatusUdgivet - 2008

ID: 14150547