Nephron blood flow dynamics measured by laser speckle contrast imaging

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Nephron blood flow dynamics measured by laser speckle contrast imaging. / von Holstein-Rathlou, Niels-Henrik; Sosnovtseva, Olga V; Pavlov, Alexey N; Cupples, William A; Sørensen, Charlotte Mehlin; Marsh, Donald J.

I: American Journal of Physiology: Renal Physiology, Bind 300, Nr. 2, 01.02.2011, s. F319-29.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

von Holstein-Rathlou, N-H, Sosnovtseva, OV, Pavlov, AN, Cupples, WA, Sørensen, CM & Marsh, DJ 2011, 'Nephron blood flow dynamics measured by laser speckle contrast imaging', American Journal of Physiology: Renal Physiology, bind 300, nr. 2, s. F319-29. https://doi.org/10.1152/ajprenal.00417.2010

APA

von Holstein-Rathlou, N-H., Sosnovtseva, O. V., Pavlov, A. N., Cupples, W. A., Sørensen, C. M., & Marsh, D. J. (2011). Nephron blood flow dynamics measured by laser speckle contrast imaging. American Journal of Physiology: Renal Physiology, 300(2), F319-29. https://doi.org/10.1152/ajprenal.00417.2010

Vancouver

von Holstein-Rathlou N-H, Sosnovtseva OV, Pavlov AN, Cupples WA, Sørensen CM, Marsh DJ. Nephron blood flow dynamics measured by laser speckle contrast imaging. American Journal of Physiology: Renal Physiology. 2011 feb 1;300(2):F319-29. https://doi.org/10.1152/ajprenal.00417.2010

Author

von Holstein-Rathlou, Niels-Henrik ; Sosnovtseva, Olga V ; Pavlov, Alexey N ; Cupples, William A ; Sørensen, Charlotte Mehlin ; Marsh, Donald J. / Nephron blood flow dynamics measured by laser speckle contrast imaging. I: American Journal of Physiology: Renal Physiology. 2011 ; Bind 300, Nr. 2. s. F319-29.

Bibtex

@article{4d6a3ed6c2824530a324614844b95e64,
title = "Nephron blood flow dynamics measured by laser speckle contrast imaging",
abstract = "Tubuloglomerular feedback (TGF) has an important role in autoregulation of renal blood flow and glomerular filtration rate (GFR). Because of the characteristics of signal transmission in the feedback loop, the TGF undergoes self-sustained oscillations in single-nephron blood flow, GFR, and tubular pressure and flow. Nephrons interact by exchanging electrical signals conducted electrotonically through cells of the vascular wall, leading to synchronization of the TGF-mediated oscillations. Experimental studies of these interactions have been limited to observations on two or at most three nephrons simultaneously. The interacting nephron fields are likely to be more extensive. We have turned to laser speckle contrast imaging to measure the blood flow dynamics of 50-100 nephrons simultaneously on the renal surface of anesthetized rats. We report the application of this method and describe analytic techniques for extracting the desired data and for examining them for evidence of nephron synchronization. Synchronized TGF oscillations were detected in pairs or triplets of nephrons. The amplitude and the frequency of the oscillations changed with time, as did the patterns of synchronization. Synchronization may take place among nephrons not immediately adjacent on the surface of the kidney.",
keywords = "Acetylcholine, Angiotensin II, Animals, Hemodynamics, Lasers, Male, Nephrons, Rats, Rats, Sprague-Dawley, Renal Circulation, Rheology",
author = "{von Holstein-Rathlou}, Niels-Henrik and Sosnovtseva, {Olga V} and Pavlov, {Alexey N} and Cupples, {William A} and S{\o}rensen, {Charlotte Mehlin} and Marsh, {Donald J}",
year = "2011",
month = "2",
day = "1",
doi = "10.1152/ajprenal.00417.2010",
language = "English",
volume = "300",
pages = "F319--29",
journal = "American Journal of Physiology: Renal Physiology",
issn = "1931-857X",
publisher = "American Physiological Society",
number = "2",

}

RIS

TY - JOUR

T1 - Nephron blood flow dynamics measured by laser speckle contrast imaging

AU - von Holstein-Rathlou, Niels-Henrik

AU - Sosnovtseva, Olga V

AU - Pavlov, Alexey N

AU - Cupples, William A

AU - Sørensen, Charlotte Mehlin

AU - Marsh, Donald J

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Tubuloglomerular feedback (TGF) has an important role in autoregulation of renal blood flow and glomerular filtration rate (GFR). Because of the characteristics of signal transmission in the feedback loop, the TGF undergoes self-sustained oscillations in single-nephron blood flow, GFR, and tubular pressure and flow. Nephrons interact by exchanging electrical signals conducted electrotonically through cells of the vascular wall, leading to synchronization of the TGF-mediated oscillations. Experimental studies of these interactions have been limited to observations on two or at most three nephrons simultaneously. The interacting nephron fields are likely to be more extensive. We have turned to laser speckle contrast imaging to measure the blood flow dynamics of 50-100 nephrons simultaneously on the renal surface of anesthetized rats. We report the application of this method and describe analytic techniques for extracting the desired data and for examining them for evidence of nephron synchronization. Synchronized TGF oscillations were detected in pairs or triplets of nephrons. The amplitude and the frequency of the oscillations changed with time, as did the patterns of synchronization. Synchronization may take place among nephrons not immediately adjacent on the surface of the kidney.

AB - Tubuloglomerular feedback (TGF) has an important role in autoregulation of renal blood flow and glomerular filtration rate (GFR). Because of the characteristics of signal transmission in the feedback loop, the TGF undergoes self-sustained oscillations in single-nephron blood flow, GFR, and tubular pressure and flow. Nephrons interact by exchanging electrical signals conducted electrotonically through cells of the vascular wall, leading to synchronization of the TGF-mediated oscillations. Experimental studies of these interactions have been limited to observations on two or at most three nephrons simultaneously. The interacting nephron fields are likely to be more extensive. We have turned to laser speckle contrast imaging to measure the blood flow dynamics of 50-100 nephrons simultaneously on the renal surface of anesthetized rats. We report the application of this method and describe analytic techniques for extracting the desired data and for examining them for evidence of nephron synchronization. Synchronized TGF oscillations were detected in pairs or triplets of nephrons. The amplitude and the frequency of the oscillations changed with time, as did the patterns of synchronization. Synchronization may take place among nephrons not immediately adjacent on the surface of the kidney.

KW - Acetylcholine

KW - Angiotensin II

KW - Animals

KW - Hemodynamics

KW - Lasers

KW - Male

KW - Nephrons

KW - Rats

KW - Rats, Sprague-Dawley

KW - Renal Circulation

KW - Rheology

U2 - 10.1152/ajprenal.00417.2010

DO - 10.1152/ajprenal.00417.2010

M3 - Journal article

C2 - 21048025

VL - 300

SP - F319-29

JO - American Journal of Physiology: Renal Physiology

JF - American Journal of Physiology: Renal Physiology

SN - 1931-857X

IS - 2

ER -

ID: 33720315