Myocardial perfusion of infarcted and normal myocardium in propofol-anesthetized minipigs using 82Rubidium PET

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Myocardial perfusion of infarcted and normal myocardium in propofol-anesthetized minipigs using 82Rubidium PET. / Rasmussen, Thomas; Larsen, Bjarke Follin; Kastrup, Jens; Christensen, Thomas Emil; Hammelev, Karsten Pharao; Kjær, Andreas; Hasbak, Philip.

I: Journal of Nuclear Cardiology, Bind 23, Nr. 3, 06.2016, s. 599-603.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Rasmussen, T, Larsen, BF, Kastrup, J, Christensen, TE, Hammelev, KP, Kjær, A & Hasbak, P 2016, 'Myocardial perfusion of infarcted and normal myocardium in propofol-anesthetized minipigs using 82Rubidium PET', Journal of Nuclear Cardiology, bind 23, nr. 3, s. 599-603. https://doi.org/10.1007/s12350-016-0453-z

APA

Rasmussen, T., Larsen, B. F., Kastrup, J., Christensen, T. E., Hammelev, K. P., Kjær, A., & Hasbak, P. (2016). Myocardial perfusion of infarcted and normal myocardium in propofol-anesthetized minipigs using 82Rubidium PET. Journal of Nuclear Cardiology, 23(3), 599-603. https://doi.org/10.1007/s12350-016-0453-z

Vancouver

Rasmussen T, Larsen BF, Kastrup J, Christensen TE, Hammelev KP, Kjær A o.a. Myocardial perfusion of infarcted and normal myocardium in propofol-anesthetized minipigs using 82Rubidium PET. Journal of Nuclear Cardiology. 2016 jun.;23(3):599-603. https://doi.org/10.1007/s12350-016-0453-z

Author

Rasmussen, Thomas ; Larsen, Bjarke Follin ; Kastrup, Jens ; Christensen, Thomas Emil ; Hammelev, Karsten Pharao ; Kjær, Andreas ; Hasbak, Philip. / Myocardial perfusion of infarcted and normal myocardium in propofol-anesthetized minipigs using 82Rubidium PET. I: Journal of Nuclear Cardiology. 2016 ; Bind 23, Nr. 3. s. 599-603.

Bibtex

@article{4ffa19990074459dba6b20f11f6f9573,
title = "Myocardial perfusion of infarcted and normal myocardium in propofol-anesthetized minipigs using 82Rubidium PET",
abstract = "Cardiac Rubidium-82 (82Rb) positron-emission-tomography (PET) is a good method for quantification of myocardial blood flow in man. Quantification of myocardial blood flow in animals to evaluate new treatment strategies or to understand underlying disease is also of great interest but raises some challenges. Animals, which have been anesthetized during PET acquisition, might react differently to used stress medications, and therefore difficulties might exist while evaluating the resulting PET images using standard software packages from commercial vendors optimized for human hearts. Furthermore propofol, used for anesthesia, can influence myocardial perfusion and coronary flow reserve due to its vasorelaxant effect, and interactions might exist between propofol and used stress agents, potentially affecting the result of the examination. We present cardiac 82Rb-PET studies performed in propofol-anesthetized minipigs with normal and infarcted myocardium stressed with both adenosine and dipyridamole. Despite the mentioned challenges, we were able to trace the small minipig heart with software designed for human cardiac PET and to achieve blood flow measurements comparable with results in humans with both adenosine and dipyridamole. We found dipyridamole to be a superior stress agent for this experimental setup. Finally, we were able to clearly identify the myocardial perfusion defect after an induced myocardial infarction.",
keywords = "A2A adenosine receptor agonists, coronary artery disease, infarction, myocardial, myocardial perfusion imaging, PET, pharmacologic stress",
author = "Thomas Rasmussen and Larsen, {Bjarke Follin} and Jens Kastrup and Christensen, {Thomas Emil} and Hammelev, {Karsten Pharao} and Andreas Kj{\ae}r and Philip Hasbak",
year = "2016",
month = jun,
doi = "10.1007/s12350-016-0453-z",
language = "English",
volume = "23",
pages = "599--603",
journal = "Journal of Nuclear Cardiology",
issn = "1071-3581",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Myocardial perfusion of infarcted and normal myocardium in propofol-anesthetized minipigs using 82Rubidium PET

AU - Rasmussen, Thomas

AU - Larsen, Bjarke Follin

AU - Kastrup, Jens

AU - Christensen, Thomas Emil

AU - Hammelev, Karsten Pharao

AU - Kjær, Andreas

AU - Hasbak, Philip

PY - 2016/6

Y1 - 2016/6

N2 - Cardiac Rubidium-82 (82Rb) positron-emission-tomography (PET) is a good method for quantification of myocardial blood flow in man. Quantification of myocardial blood flow in animals to evaluate new treatment strategies or to understand underlying disease is also of great interest but raises some challenges. Animals, which have been anesthetized during PET acquisition, might react differently to used stress medications, and therefore difficulties might exist while evaluating the resulting PET images using standard software packages from commercial vendors optimized for human hearts. Furthermore propofol, used for anesthesia, can influence myocardial perfusion and coronary flow reserve due to its vasorelaxant effect, and interactions might exist between propofol and used stress agents, potentially affecting the result of the examination. We present cardiac 82Rb-PET studies performed in propofol-anesthetized minipigs with normal and infarcted myocardium stressed with both adenosine and dipyridamole. Despite the mentioned challenges, we were able to trace the small minipig heart with software designed for human cardiac PET and to achieve blood flow measurements comparable with results in humans with both adenosine and dipyridamole. We found dipyridamole to be a superior stress agent for this experimental setup. Finally, we were able to clearly identify the myocardial perfusion defect after an induced myocardial infarction.

AB - Cardiac Rubidium-82 (82Rb) positron-emission-tomography (PET) is a good method for quantification of myocardial blood flow in man. Quantification of myocardial blood flow in animals to evaluate new treatment strategies or to understand underlying disease is also of great interest but raises some challenges. Animals, which have been anesthetized during PET acquisition, might react differently to used stress medications, and therefore difficulties might exist while evaluating the resulting PET images using standard software packages from commercial vendors optimized for human hearts. Furthermore propofol, used for anesthesia, can influence myocardial perfusion and coronary flow reserve due to its vasorelaxant effect, and interactions might exist between propofol and used stress agents, potentially affecting the result of the examination. We present cardiac 82Rb-PET studies performed in propofol-anesthetized minipigs with normal and infarcted myocardium stressed with both adenosine and dipyridamole. Despite the mentioned challenges, we were able to trace the small minipig heart with software designed for human cardiac PET and to achieve blood flow measurements comparable with results in humans with both adenosine and dipyridamole. We found dipyridamole to be a superior stress agent for this experimental setup. Finally, we were able to clearly identify the myocardial perfusion defect after an induced myocardial infarction.

KW - A2A adenosine receptor agonists

KW - coronary artery disease

KW - infarction

KW - myocardial

KW - myocardial perfusion imaging

KW - PET

KW - pharmacologic stress

U2 - 10.1007/s12350-016-0453-z

DO - 10.1007/s12350-016-0453-z

M3 - Journal article

C2 - 26931633

AN - SCOPUS:84959542899

VL - 23

SP - 599

EP - 603

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

SN - 1071-3581

IS - 3

ER -

ID: 159919738