Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and Caucasians in the arctic winter
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Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and Caucasians in the arctic winter. / Gnaiger, E; Boushel, R; Søndergaard, H; Munch-Andersen, T; Damsgaard, R; Hagen, C; Díez-Sánchez, C; Ara, I; Wright-Paradis, C; Schrauwen, P; Hesselink, M; Calbet, J A L; Christiansen, M; Helge, J W; Saltin, B.
I: Scandinavian Journal of Medicine & Science in Sports, Bind 25, Nr. Suppl 4, 2015, s. 126-34.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and Caucasians in the arctic winter
AU - Gnaiger, E
AU - Boushel, R
AU - Søndergaard, H
AU - Munch-Andersen, T
AU - Damsgaard, R
AU - Hagen, C
AU - Díez-Sánchez, C
AU - Ara, I
AU - Wright-Paradis, C
AU - Schrauwen, P
AU - Hesselink, M
AU - Calbet, J A L
AU - Christiansen, M
AU - Helge, J W
AU - Saltin, B
N1 - © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2015
Y1 - 2015
N2 - During evolution, mitochondrial DNA haplogroups of arctic populations may have been selected for lower coupling of mitochondrial respiration to ATP production in favor of higher heat production. We show that mitochondrial coupling in skeletal muscle of traditional and westernized Inuit habituating northern Greenland is identical to Danes of western Europe haplogroups. Biochemical coupling efficiency was preserved across variations in diet, muscle fiber type, and uncoupling protein-3 content. Mitochondrial phenotype displayed plasticity in relation to lifestyle and environment. Untrained Inuit and Danes had identical capacities to oxidize fat substrate in arm muscle, which increased in Danes during the 42 days of acclimation to exercise, approaching the higher level of the Inuit hunters. A common pattern emerges of mitochondrial acclimatization and evolutionary adaptation in humans at high latitude and high altitude where economy of locomotion may be optimized by preservation of biochemical coupling efficiency at modest mitochondrial density, when submaximum performance is uncoupled from VO2max and maximum capacities of oxidative phosphorylation.
AB - During evolution, mitochondrial DNA haplogroups of arctic populations may have been selected for lower coupling of mitochondrial respiration to ATP production in favor of higher heat production. We show that mitochondrial coupling in skeletal muscle of traditional and westernized Inuit habituating northern Greenland is identical to Danes of western Europe haplogroups. Biochemical coupling efficiency was preserved across variations in diet, muscle fiber type, and uncoupling protein-3 content. Mitochondrial phenotype displayed plasticity in relation to lifestyle and environment. Untrained Inuit and Danes had identical capacities to oxidize fat substrate in arm muscle, which increased in Danes during the 42 days of acclimation to exercise, approaching the higher level of the Inuit hunters. A common pattern emerges of mitochondrial acclimatization and evolutionary adaptation in humans at high latitude and high altitude where economy of locomotion may be optimized by preservation of biochemical coupling efficiency at modest mitochondrial density, when submaximum performance is uncoupled from VO2max and maximum capacities of oxidative phosphorylation.
KW - Adenosine Triphosphate
KW - Adult
KW - Cell Respiration
KW - Cold Temperature
KW - DNA, Mitochondrial
KW - Deltoid Muscle
KW - Denmark
KW - European Continental Ancestry Group
KW - Fatty Acids
KW - Female
KW - Greenland
KW - Haplotypes
KW - Humans
KW - Inuits
KW - Ion Channels
KW - Male
KW - Mitochondria, Muscle
KW - Mitochondrial Proteins
KW - Oxidation-Reduction
KW - Oxidative Phosphorylation
KW - Oxygen Consumption
KW - Quadriceps Muscle
KW - Seasons
KW - Skiing
KW - Thermogenesis
KW - Uncoupling Protein 3
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1111/sms.12612
DO - 10.1111/sms.12612
M3 - Journal article
C2 - 26589126
VL - 25
SP - 126
EP - 134
JO - Scandinavian Journal of Medicine & Science in Sports
JF - Scandinavian Journal of Medicine & Science in Sports
SN - 0905-7188
IS - Suppl 4
ER -
ID: 184740536