Minimal T-wave representation and its use in the assessment of drug arrhythmogenicity

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Minimal T-wave representation and its use in the assessment of drug arrhythmogenicity. / Shakibfar, Saeed; Graff, Claus; Kanters, Jørgen K; Nielsen, Jimmi; Schmidt, Samuel; Struijk, Johannes J.

I: Annals of Noninvasive Electrocardiology, Bind 22, Nr. 3, e12413, 05.2017.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Shakibfar, S, Graff, C, Kanters, JK, Nielsen, J, Schmidt, S & Struijk, JJ 2017, 'Minimal T-wave representation and its use in the assessment of drug arrhythmogenicity', Annals of Noninvasive Electrocardiology, bind 22, nr. 3, e12413. https://doi.org/10.1111/anec.12413

APA

Shakibfar, S., Graff, C., Kanters, J. K., Nielsen, J., Schmidt, S., & Struijk, J. J. (2017). Minimal T-wave representation and its use in the assessment of drug arrhythmogenicity. Annals of Noninvasive Electrocardiology, 22(3), [e12413]. https://doi.org/10.1111/anec.12413

Vancouver

Shakibfar S, Graff C, Kanters JK, Nielsen J, Schmidt S, Struijk JJ. Minimal T-wave representation and its use in the assessment of drug arrhythmogenicity. Annals of Noninvasive Electrocardiology. 2017 maj;22(3). e12413. https://doi.org/10.1111/anec.12413

Author

Shakibfar, Saeed ; Graff, Claus ; Kanters, Jørgen K ; Nielsen, Jimmi ; Schmidt, Samuel ; Struijk, Johannes J. / Minimal T-wave representation and its use in the assessment of drug arrhythmogenicity. I: Annals of Noninvasive Electrocardiology. 2017 ; Bind 22, Nr. 3.

Bibtex

@article{53d3227d76024e319bbbec28924f5e85,
title = "Minimal T-wave representation and its use in the assessment of drug arrhythmogenicity",
abstract = "BACKGROUND: Recently, numerous models and techniques have been developed for analyzing and extracting features from the T wave which could be used as biomarkers for drug-induced abnormalities. The majority of these techniques and algorithms use features that determine readily apparent characteristics of the T wave, such as duration, area, amplitude, and slopes.METHODS: In the present work the T wave was down-sampled to a minimal rate, such that a good reconstruction was still possible. The entire T wave was then used as a feature vector to assess drug-induced repolarization effects. The ability of the samples or combinations of samples obtained from the minimal T-wave representation to correctly classify a group of subjects before and after receiving d,l-sotalol 160 mg and 320 mg was evaluated using a linear discriminant analysis (LDA).RESULTS: The results showed that a combination of eight samples from the minimal T-wave representation can be used to identify normal from abnormal repolarization significantly better compared to the heart rate-corrected QT interval (QTc). It was further indicated that the interval from the peak of the T wave to the end of the T wave (Tpe) becomes relatively shorter after IKr inhibition by d,l-sotalol and that the most pronounced repolarization changes were present in the ascending segment of the minimal T-wave representation.CONCLUSIONS: The minimal T-wave representation can potentially be used as a new tool to identify normal from abnormal repolarization in drug safety studies.",
author = "Saeed Shakibfar and Claus Graff and Kanters, {J{\o}rgen K} and Jimmi Nielsen and Samuel Schmidt and Struijk, {Johannes J}",
note = "{\textcopyright} 2016 Wiley Periodicals, Inc.",
year = "2017",
month = may,
doi = "10.1111/anec.12413",
language = "English",
volume = "22",
journal = "Annals of Noninvasive Electrocardiology (Print)",
issn = "1082-720X",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Minimal T-wave representation and its use in the assessment of drug arrhythmogenicity

AU - Shakibfar, Saeed

AU - Graff, Claus

AU - Kanters, Jørgen K

AU - Nielsen, Jimmi

AU - Schmidt, Samuel

AU - Struijk, Johannes J

N1 - © 2016 Wiley Periodicals, Inc.

PY - 2017/5

Y1 - 2017/5

N2 - BACKGROUND: Recently, numerous models and techniques have been developed for analyzing and extracting features from the T wave which could be used as biomarkers for drug-induced abnormalities. The majority of these techniques and algorithms use features that determine readily apparent characteristics of the T wave, such as duration, area, amplitude, and slopes.METHODS: In the present work the T wave was down-sampled to a minimal rate, such that a good reconstruction was still possible. The entire T wave was then used as a feature vector to assess drug-induced repolarization effects. The ability of the samples or combinations of samples obtained from the minimal T-wave representation to correctly classify a group of subjects before and after receiving d,l-sotalol 160 mg and 320 mg was evaluated using a linear discriminant analysis (LDA).RESULTS: The results showed that a combination of eight samples from the minimal T-wave representation can be used to identify normal from abnormal repolarization significantly better compared to the heart rate-corrected QT interval (QTc). It was further indicated that the interval from the peak of the T wave to the end of the T wave (Tpe) becomes relatively shorter after IKr inhibition by d,l-sotalol and that the most pronounced repolarization changes were present in the ascending segment of the minimal T-wave representation.CONCLUSIONS: The minimal T-wave representation can potentially be used as a new tool to identify normal from abnormal repolarization in drug safety studies.

AB - BACKGROUND: Recently, numerous models and techniques have been developed for analyzing and extracting features from the T wave which could be used as biomarkers for drug-induced abnormalities. The majority of these techniques and algorithms use features that determine readily apparent characteristics of the T wave, such as duration, area, amplitude, and slopes.METHODS: In the present work the T wave was down-sampled to a minimal rate, such that a good reconstruction was still possible. The entire T wave was then used as a feature vector to assess drug-induced repolarization effects. The ability of the samples or combinations of samples obtained from the minimal T-wave representation to correctly classify a group of subjects before and after receiving d,l-sotalol 160 mg and 320 mg was evaluated using a linear discriminant analysis (LDA).RESULTS: The results showed that a combination of eight samples from the minimal T-wave representation can be used to identify normal from abnormal repolarization significantly better compared to the heart rate-corrected QT interval (QTc). It was further indicated that the interval from the peak of the T wave to the end of the T wave (Tpe) becomes relatively shorter after IKr inhibition by d,l-sotalol and that the most pronounced repolarization changes were present in the ascending segment of the minimal T-wave representation.CONCLUSIONS: The minimal T-wave representation can potentially be used as a new tool to identify normal from abnormal repolarization in drug safety studies.

U2 - 10.1111/anec.12413

DO - 10.1111/anec.12413

M3 - Journal article

C2 - 27785856

VL - 22

JO - Annals of Noninvasive Electrocardiology (Print)

JF - Annals of Noninvasive Electrocardiology (Print)

SN - 1082-720X

IS - 3

M1 - e12413

ER -

ID: 169008779