Microvascular Imaging with Super-Resolution Ultrasound

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Microvascular Imaging with Super-Resolution Ultrasound. / Andersen, Sofie Bech; Sørensen, Charlotte Mehlin; Jensen, Jørgen Arendt; Nielsen, Michael Bachmann.

I: Ultraschall in der Medizin, Bind 43, Nr. 6, 2022, s. 543-547.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Andersen, SB, Sørensen, CM, Jensen, JA & Nielsen, MB 2022, 'Microvascular Imaging with Super-Resolution Ultrasound', Ultraschall in der Medizin, bind 43, nr. 6, s. 543-547. https://doi.org/10.1055/a-1937-6868

APA

Andersen, S. B., Sørensen, C. M., Jensen, J. A., & Nielsen, M. B. (2022). Microvascular Imaging with Super-Resolution Ultrasound. Ultraschall in der Medizin, 43(6), 543-547. https://doi.org/10.1055/a-1937-6868

Vancouver

Andersen SB, Sørensen CM, Jensen JA, Nielsen MB. Microvascular Imaging with Super-Resolution Ultrasound. Ultraschall in der Medizin. 2022;43(6):543-547. https://doi.org/10.1055/a-1937-6868

Author

Andersen, Sofie Bech ; Sørensen, Charlotte Mehlin ; Jensen, Jørgen Arendt ; Nielsen, Michael Bachmann. / Microvascular Imaging with Super-Resolution Ultrasound. I: Ultraschall in der Medizin. 2022 ; Bind 43, Nr. 6. s. 543-547.

Bibtex

@article{fefd2b2df00546d9b5accfa260903e3f,
title = "Microvascular Imaging with Super-Resolution Ultrasound",
abstract = "Super-resolution ultrasound imaging (SRUS) is a branch of ultrasound techniques aiming to image and quantify the vasculature beyond the diffraction limit [1]. Going beyond the diffraction limit of conventional ultrasound entails the possibility of imaging the microvasculature, namely arterioles, venules, and maybe even the smallest vessels in the body: the capillaries. In one of the main SRUS techniques, also called ultrasound localization microscopy, isolated microbubbles from ultrasound contrast agents are used to acquire data for SRUS image formation. Super-resolution ultrasound imaging using isolated microbubbles was inspired by one of the Nobel prize-winning approaches for super-resolution microscopy [2]. In one of these approaches, the ability to turn the fluorescence of single molecules on and off was used. By capturing numerous images of the same object, each image with a different group of molecules fluorescently turned on and superposing the resultant image stack, a super-resolved microscopy image, i. e., an image showing structures below the diffraction limit of light, could be created. Likewise, the SRUS images are created by superposing thousands of successive ultrasound images of isolated microbubbles as they move through the vasculature. More specifically, the SRUS images are created using a series of post-processing steps. After scanning the organ or tissue of interest, the sparsely distributed intravascular microbubbles must be detected. Detection can be done with, e. g., contrast-enhancing sequences, such as pulse inversion or amplitude modulation, or with singular value decomposition (SVD) techniques [3]. Next, the single microbubbles are isolated and localized [4]. The precision of this localization is a critical step in obtaining super-resolution [5]. Instead of merely superposing each of the microbubble localizations, as done in super-resolution microscopy, the movements of the microbubbles as they follow the bloodstream between frames are used to create trajectories that can reveal microbubble velocity and direction [6] [7] [8] [9] [10]. Lastly, another essential difference between super-resolved microscopy and ultrasound is motion. In order to localize the microbubbles precisely, it is necessary to compensate for the motion that stems from, e. g., breathing and heart beating during scanning ",
keywords = "Humans, Ultrasonography/methods, Microbubbles",
author = "Andersen, {Sofie Bech} and S{\o}rensen, {Charlotte Mehlin} and Jensen, {J{\o}rgen Arendt} and Nielsen, {Michael Bachmann}",
year = "2022",
doi = "10.1055/a-1937-6868",
language = "English",
volume = "43",
pages = "543--547",
journal = "Ultraschall in der Medizin",
issn = "0172-4614",
publisher = "GeorgThieme Verlag",
number = "6",

}

RIS

TY - JOUR

T1 - Microvascular Imaging with Super-Resolution Ultrasound

AU - Andersen, Sofie Bech

AU - Sørensen, Charlotte Mehlin

AU - Jensen, Jørgen Arendt

AU - Nielsen, Michael Bachmann

PY - 2022

Y1 - 2022

N2 - Super-resolution ultrasound imaging (SRUS) is a branch of ultrasound techniques aiming to image and quantify the vasculature beyond the diffraction limit [1]. Going beyond the diffraction limit of conventional ultrasound entails the possibility of imaging the microvasculature, namely arterioles, venules, and maybe even the smallest vessels in the body: the capillaries. In one of the main SRUS techniques, also called ultrasound localization microscopy, isolated microbubbles from ultrasound contrast agents are used to acquire data for SRUS image formation. Super-resolution ultrasound imaging using isolated microbubbles was inspired by one of the Nobel prize-winning approaches for super-resolution microscopy [2]. In one of these approaches, the ability to turn the fluorescence of single molecules on and off was used. By capturing numerous images of the same object, each image with a different group of molecules fluorescently turned on and superposing the resultant image stack, a super-resolved microscopy image, i. e., an image showing structures below the diffraction limit of light, could be created. Likewise, the SRUS images are created by superposing thousands of successive ultrasound images of isolated microbubbles as they move through the vasculature. More specifically, the SRUS images are created using a series of post-processing steps. After scanning the organ or tissue of interest, the sparsely distributed intravascular microbubbles must be detected. Detection can be done with, e. g., contrast-enhancing sequences, such as pulse inversion or amplitude modulation, or with singular value decomposition (SVD) techniques [3]. Next, the single microbubbles are isolated and localized [4]. The precision of this localization is a critical step in obtaining super-resolution [5]. Instead of merely superposing each of the microbubble localizations, as done in super-resolution microscopy, the movements of the microbubbles as they follow the bloodstream between frames are used to create trajectories that can reveal microbubble velocity and direction [6] [7] [8] [9] [10]. Lastly, another essential difference between super-resolved microscopy and ultrasound is motion. In order to localize the microbubbles precisely, it is necessary to compensate for the motion that stems from, e. g., breathing and heart beating during scanning

AB - Super-resolution ultrasound imaging (SRUS) is a branch of ultrasound techniques aiming to image and quantify the vasculature beyond the diffraction limit [1]. Going beyond the diffraction limit of conventional ultrasound entails the possibility of imaging the microvasculature, namely arterioles, venules, and maybe even the smallest vessels in the body: the capillaries. In one of the main SRUS techniques, also called ultrasound localization microscopy, isolated microbubbles from ultrasound contrast agents are used to acquire data for SRUS image formation. Super-resolution ultrasound imaging using isolated microbubbles was inspired by one of the Nobel prize-winning approaches for super-resolution microscopy [2]. In one of these approaches, the ability to turn the fluorescence of single molecules on and off was used. By capturing numerous images of the same object, each image with a different group of molecules fluorescently turned on and superposing the resultant image stack, a super-resolved microscopy image, i. e., an image showing structures below the diffraction limit of light, could be created. Likewise, the SRUS images are created by superposing thousands of successive ultrasound images of isolated microbubbles as they move through the vasculature. More specifically, the SRUS images are created using a series of post-processing steps. After scanning the organ or tissue of interest, the sparsely distributed intravascular microbubbles must be detected. Detection can be done with, e. g., contrast-enhancing sequences, such as pulse inversion or amplitude modulation, or with singular value decomposition (SVD) techniques [3]. Next, the single microbubbles are isolated and localized [4]. The precision of this localization is a critical step in obtaining super-resolution [5]. Instead of merely superposing each of the microbubble localizations, as done in super-resolution microscopy, the movements of the microbubbles as they follow the bloodstream between frames are used to create trajectories that can reveal microbubble velocity and direction [6] [7] [8] [9] [10]. Lastly, another essential difference between super-resolved microscopy and ultrasound is motion. In order to localize the microbubbles precisely, it is necessary to compensate for the motion that stems from, e. g., breathing and heart beating during scanning

KW - Humans

KW - Ultrasonography/methods

KW - Microbubbles

U2 - 10.1055/a-1937-6868

DO - 10.1055/a-1937-6868

M3 - Journal article

C2 - 36470255

VL - 43

SP - 543

EP - 547

JO - Ultraschall in der Medizin

JF - Ultraschall in der Medizin

SN - 0172-4614

IS - 6

ER -

ID: 328531427