Metabolic trajectories based on 1H NMR spectra of urines from sheep exposed to nutritional challenges during prenatal and early postnatal life

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Metabolic trajectories based on 1H NMR spectra of urines from sheep exposed to nutritional challenges during prenatal and early postnatal life. / Nyberg, Nils; Nielsen, Mette Benedicte Olaf; Jaroszewski, Jerzy W.

I: Metabolomics, Bind 6, Nr. 4, 2010, s. 489-496.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Nyberg, N, Nielsen, MBO & Jaroszewski, JW 2010, 'Metabolic trajectories based on 1H NMR spectra of urines from sheep exposed to nutritional challenges during prenatal and early postnatal life', Metabolomics, bind 6, nr. 4, s. 489-496. https://doi.org/10.1007/s11306-010-0229-4

APA

Nyberg, N., Nielsen, M. B. O., & Jaroszewski, J. W. (2010). Metabolic trajectories based on 1H NMR spectra of urines from sheep exposed to nutritional challenges during prenatal and early postnatal life. Metabolomics, 6(4), 489-496. https://doi.org/10.1007/s11306-010-0229-4

Vancouver

Nyberg N, Nielsen MBO, Jaroszewski JW. Metabolic trajectories based on 1H NMR spectra of urines from sheep exposed to nutritional challenges during prenatal and early postnatal life. Metabolomics. 2010;6(4):489-496. https://doi.org/10.1007/s11306-010-0229-4

Author

Nyberg, Nils ; Nielsen, Mette Benedicte Olaf ; Jaroszewski, Jerzy W. / Metabolic trajectories based on 1H NMR spectra of urines from sheep exposed to nutritional challenges during prenatal and early postnatal life. I: Metabolomics. 2010 ; Bind 6, Nr. 4. s. 489-496.

Bibtex

@article{55fc6f40e74911dfb6d2000ea68e967b,
title = "Metabolic trajectories based on 1H NMR spectra of urines from sheep exposed to nutritional challenges during prenatal and early postnatal life",
abstract = "1H NMR metabolic profiles of urine from sheep exposed to prenatal nutritional restriction (n = 19) and a control group with normal prenatal nutritional requirements (n = 19), followed by either conventional (n = 10 + 10) or high carbohydrate high fat postnatal diet (n = 9 + 9), were studied. Urine was sampled from 2, 6, 19 and 24-month-old animals receiving differential dietary treatments during the first 6 months and the same normal diet later. Principal component analysis of 1H NMR spectra (n = 164) showed a V-shaped metabolic trajectory as a function of age and diet, starting with urines with a high amount of glucose, indicative of monogastric-like metabolism, and exhibiting concomitant increase of metabolites related to rumen microflora (mainly glycine conjugates of benzoic and phenylacetic acid) as the ruminal metabolism developed. Urines from young (2-month-old) animals exposed to prenatal undernutrition followed by normal postnatal diet showed metabolic patters that are ahead in time on the metabolic trajectory relative to the prenatal control group. No long-term effects of fetal undernutrition, alone or in combination with postnatal hypernutrition were observed.",
keywords = "Former LIFE faculty",
author = "Nils Nyberg and Nielsen, {Mette Benedicte Olaf} and Jaroszewski, {Jerzy W.}",
note = "Keywords: NMR, metabolic trajectory, fetal programming, urine, sheep, metabolomics",
year = "2010",
doi = "10.1007/s11306-010-0229-4",
language = "English",
volume = "6",
pages = "489--496",
journal = "Metabolomics",
issn = "1573-3882",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - Metabolic trajectories based on 1H NMR spectra of urines from sheep exposed to nutritional challenges during prenatal and early postnatal life

AU - Nyberg, Nils

AU - Nielsen, Mette Benedicte Olaf

AU - Jaroszewski, Jerzy W.

N1 - Keywords: NMR, metabolic trajectory, fetal programming, urine, sheep, metabolomics

PY - 2010

Y1 - 2010

N2 - 1H NMR metabolic profiles of urine from sheep exposed to prenatal nutritional restriction (n = 19) and a control group with normal prenatal nutritional requirements (n = 19), followed by either conventional (n = 10 + 10) or high carbohydrate high fat postnatal diet (n = 9 + 9), were studied. Urine was sampled from 2, 6, 19 and 24-month-old animals receiving differential dietary treatments during the first 6 months and the same normal diet later. Principal component analysis of 1H NMR spectra (n = 164) showed a V-shaped metabolic trajectory as a function of age and diet, starting with urines with a high amount of glucose, indicative of monogastric-like metabolism, and exhibiting concomitant increase of metabolites related to rumen microflora (mainly glycine conjugates of benzoic and phenylacetic acid) as the ruminal metabolism developed. Urines from young (2-month-old) animals exposed to prenatal undernutrition followed by normal postnatal diet showed metabolic patters that are ahead in time on the metabolic trajectory relative to the prenatal control group. No long-term effects of fetal undernutrition, alone or in combination with postnatal hypernutrition were observed.

AB - 1H NMR metabolic profiles of urine from sheep exposed to prenatal nutritional restriction (n = 19) and a control group with normal prenatal nutritional requirements (n = 19), followed by either conventional (n = 10 + 10) or high carbohydrate high fat postnatal diet (n = 9 + 9), were studied. Urine was sampled from 2, 6, 19 and 24-month-old animals receiving differential dietary treatments during the first 6 months and the same normal diet later. Principal component analysis of 1H NMR spectra (n = 164) showed a V-shaped metabolic trajectory as a function of age and diet, starting with urines with a high amount of glucose, indicative of monogastric-like metabolism, and exhibiting concomitant increase of metabolites related to rumen microflora (mainly glycine conjugates of benzoic and phenylacetic acid) as the ruminal metabolism developed. Urines from young (2-month-old) animals exposed to prenatal undernutrition followed by normal postnatal diet showed metabolic patters that are ahead in time on the metabolic trajectory relative to the prenatal control group. No long-term effects of fetal undernutrition, alone or in combination with postnatal hypernutrition were observed.

KW - Former LIFE faculty

U2 - 10.1007/s11306-010-0229-4

DO - 10.1007/s11306-010-0229-4

M3 - Journal article

VL - 6

SP - 489

EP - 496

JO - Metabolomics

JF - Metabolomics

SN - 1573-3882

IS - 4

ER -

ID: 22907245