Maternal endometrial oedema may increase perinatal mortality of cloned and transgenic piglets

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Maternal endometrial oedema may increase perinatal mortality of cloned and transgenic piglets. / Schmidt, Mette; Winter, K.D.; Dantzer, Vibeke; Li, J.; Kragh, P.M.; Du, Y.; Lin, L.; Liu, Y.; Vajta, Gabor; Sangild, Per Torp; Callesen, Henrik; Agerholm, Jørgen Steen.

I: Reproduction, Fertility and Development, Bind 23, Nr. 5, 2011, s. 645-653.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Schmidt, M, Winter, KD, Dantzer, V, Li, J, Kragh, PM, Du, Y, Lin, L, Liu, Y, Vajta, G, Sangild, PT, Callesen, H & Agerholm, JS 2011, 'Maternal endometrial oedema may increase perinatal mortality of cloned and transgenic piglets', Reproduction, Fertility and Development, bind 23, nr. 5, s. 645-653. https://doi.org/10.1071/RD10220

APA

Schmidt, M., Winter, K. D., Dantzer, V., Li, J., Kragh, P. M., Du, Y., Lin, L., Liu, Y., Vajta, G., Sangild, P. T., Callesen, H., & Agerholm, J. S. (2011). Maternal endometrial oedema may increase perinatal mortality of cloned and transgenic piglets. Reproduction, Fertility and Development, 23(5), 645-653. https://doi.org/10.1071/RD10220

Vancouver

Schmidt M, Winter KD, Dantzer V, Li J, Kragh PM, Du Y o.a. Maternal endometrial oedema may increase perinatal mortality of cloned and transgenic piglets. Reproduction, Fertility and Development. 2011;23(5):645-653. https://doi.org/10.1071/RD10220

Author

Schmidt, Mette ; Winter, K.D. ; Dantzer, Vibeke ; Li, J. ; Kragh, P.M. ; Du, Y. ; Lin, L. ; Liu, Y. ; Vajta, Gabor ; Sangild, Per Torp ; Callesen, Henrik ; Agerholm, Jørgen Steen. / Maternal endometrial oedema may increase perinatal mortality of cloned and transgenic piglets. I: Reproduction, Fertility and Development. 2011 ; Bind 23, Nr. 5. s. 645-653.

Bibtex

@article{5ac5be8f1a364baba79af016b7d5268a,
title = "Maternal endometrial oedema may increase perinatal mortality of cloned and transgenic piglets",
abstract = "The perinatal mortality of cloned animals is a well-known problem. In the present retrospective study, we report on mortality of cloned transgenic or non-transgenic piglets produced as part of several investigations. Large White (LW) sows (n = 105) received hand-made cloned LW or minipig blastocysts and delivered either spontaneously or after prostaglandin induction followed by either Caesarean section or vaginal birth. The overall pregnancy rate was 62%, with 26% of pregnancies terminating before term. This resulted in 48 deliveries. The terminated pregnancies consisted of 12 abortions that occurred at 35 ± 2 days gestation and five sows that went to term without returning to heat and then by surgery showed the uterus without fetal content. The gestation length was for sows with LW piglets that delivered by Caesarean section or vaginally was 115.7 ± 0.3 and 117.6 ± 0.4 days, respectively. In sows with minipiglets, the gestation length for those delivered by Caesarean section or vaginally 114.4 ± 0.2 and 115.5 ± 0.3 days, respectively. Of the 34 sows that delivered vaginally, 28 gave birth after induction, whereas 6 farrowed spontaneously. Of the 14 sows that delivered after Caesarean section and in the five empty sows, the endometrium and placenta showed severe oedema. Piglet mortality following vaginal delivery was higher than after Caesarean section (31% v. 10%, respectively; P < 0.001). When vaginal delivery occurred spontaneously, the stillborn rate was greater than after induced delivery (56% v. 24%, respectively; P < 0.0001). Internal organ weights were recorded for seven cloned LW piglets and six normal piglets. The relative weight of the heart, liver, kidneys and small intestine was found to be reduced in the cloned piglets (P < 0.05). The present study demonstrates extensive endometrial oedema in sows pregnant with cloned and transgenic piglets, as well as in empty recipients, at term. The growth of certain organs in some of the cloned piglets was reduced and the rate of stillborn piglets was greater in cloned and transgenic piglets delivered vaginally, possibly because of oedema of the fetal–maternal interface. ",
keywords = "Former LIFE faculty, birth method, endometrium, organ weight, placenta, stillbirth, survival",
author = "Mette Schmidt and K.D. Winter and Vibeke Dantzer and J. Li and P.M. Kragh and Y. Du and L. Lin and Y. Liu and Gabor Vajta and Sangild, {Per Torp} and Henrik Callesen and Agerholm, {J{\o}rgen Steen}",
year = "2011",
doi = "10.1071/RD10220",
language = "English",
volume = "23",
pages = "645--653",
journal = "Australian journal of scientific research. Ser. B: Biological sciences",
issn = "1031-3613",
publisher = "C S I R O Publishing",
number = "5",

}

RIS

TY - JOUR

T1 - Maternal endometrial oedema may increase perinatal mortality of cloned and transgenic piglets

AU - Schmidt, Mette

AU - Winter, K.D.

AU - Dantzer, Vibeke

AU - Li, J.

AU - Kragh, P.M.

AU - Du, Y.

AU - Lin, L.

AU - Liu, Y.

AU - Vajta, Gabor

AU - Sangild, Per Torp

AU - Callesen, Henrik

AU - Agerholm, Jørgen Steen

PY - 2011

Y1 - 2011

N2 - The perinatal mortality of cloned animals is a well-known problem. In the present retrospective study, we report on mortality of cloned transgenic or non-transgenic piglets produced as part of several investigations. Large White (LW) sows (n = 105) received hand-made cloned LW or minipig blastocysts and delivered either spontaneously or after prostaglandin induction followed by either Caesarean section or vaginal birth. The overall pregnancy rate was 62%, with 26% of pregnancies terminating before term. This resulted in 48 deliveries. The terminated pregnancies consisted of 12 abortions that occurred at 35 ± 2 days gestation and five sows that went to term without returning to heat and then by surgery showed the uterus without fetal content. The gestation length was for sows with LW piglets that delivered by Caesarean section or vaginally was 115.7 ± 0.3 and 117.6 ± 0.4 days, respectively. In sows with minipiglets, the gestation length for those delivered by Caesarean section or vaginally 114.4 ± 0.2 and 115.5 ± 0.3 days, respectively. Of the 34 sows that delivered vaginally, 28 gave birth after induction, whereas 6 farrowed spontaneously. Of the 14 sows that delivered after Caesarean section and in the five empty sows, the endometrium and placenta showed severe oedema. Piglet mortality following vaginal delivery was higher than after Caesarean section (31% v. 10%, respectively; P < 0.001). When vaginal delivery occurred spontaneously, the stillborn rate was greater than after induced delivery (56% v. 24%, respectively; P < 0.0001). Internal organ weights were recorded for seven cloned LW piglets and six normal piglets. The relative weight of the heart, liver, kidneys and small intestine was found to be reduced in the cloned piglets (P < 0.05). The present study demonstrates extensive endometrial oedema in sows pregnant with cloned and transgenic piglets, as well as in empty recipients, at term. The growth of certain organs in some of the cloned piglets was reduced and the rate of stillborn piglets was greater in cloned and transgenic piglets delivered vaginally, possibly because of oedema of the fetal–maternal interface.

AB - The perinatal mortality of cloned animals is a well-known problem. In the present retrospective study, we report on mortality of cloned transgenic or non-transgenic piglets produced as part of several investigations. Large White (LW) sows (n = 105) received hand-made cloned LW or minipig blastocysts and delivered either spontaneously or after prostaglandin induction followed by either Caesarean section or vaginal birth. The overall pregnancy rate was 62%, with 26% of pregnancies terminating before term. This resulted in 48 deliveries. The terminated pregnancies consisted of 12 abortions that occurred at 35 ± 2 days gestation and five sows that went to term without returning to heat and then by surgery showed the uterus without fetal content. The gestation length was for sows with LW piglets that delivered by Caesarean section or vaginally was 115.7 ± 0.3 and 117.6 ± 0.4 days, respectively. In sows with minipiglets, the gestation length for those delivered by Caesarean section or vaginally 114.4 ± 0.2 and 115.5 ± 0.3 days, respectively. Of the 34 sows that delivered vaginally, 28 gave birth after induction, whereas 6 farrowed spontaneously. Of the 14 sows that delivered after Caesarean section and in the five empty sows, the endometrium and placenta showed severe oedema. Piglet mortality following vaginal delivery was higher than after Caesarean section (31% v. 10%, respectively; P < 0.001). When vaginal delivery occurred spontaneously, the stillborn rate was greater than after induced delivery (56% v. 24%, respectively; P < 0.0001). Internal organ weights were recorded for seven cloned LW piglets and six normal piglets. The relative weight of the heart, liver, kidneys and small intestine was found to be reduced in the cloned piglets (P < 0.05). The present study demonstrates extensive endometrial oedema in sows pregnant with cloned and transgenic piglets, as well as in empty recipients, at term. The growth of certain organs in some of the cloned piglets was reduced and the rate of stillborn piglets was greater in cloned and transgenic piglets delivered vaginally, possibly because of oedema of the fetal–maternal interface.

KW - Former LIFE faculty

KW - birth method

KW - endometrium

KW - organ weight

KW - placenta

KW - stillbirth

KW - survival

U2 - 10.1071/RD10220

DO - 10.1071/RD10220

M3 - Journal article

C2 - 21635813

VL - 23

SP - 645

EP - 653

JO - Australian journal of scientific research. Ser. B: Biological sciences

JF - Australian journal of scientific research. Ser. B: Biological sciences

SN - 1031-3613

IS - 5

ER -

ID: 33364980