Markers of Local Inflammation and Bone Resorption in the Acute Diabetic Charcot Foot

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Standard

Markers of Local Inflammation and Bone Resorption in the Acute Diabetic Charcot Foot. / Jansen, Rasmus Bo; Christensen, Tomas Møller; Bülow, Jens; Rørdam, Lene; Jørgensen, Niklas Rye; Svendsen, Ole Lander.

I: Journal of Diabetes Research, Bind 2018, 5647981, 2018, s. 1-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Jansen, RB, Christensen, TM, Bülow, J, Rørdam, L, Jørgensen, NR & Svendsen, OL 2018, 'Markers of Local Inflammation and Bone Resorption in the Acute Diabetic Charcot Foot', Journal of Diabetes Research, bind 2018, 5647981, s. 1-9. https://doi.org/10.1155/2018/5647981

APA

Jansen, R. B., Christensen, T. M., Bülow, J., Rørdam, L., Jørgensen, N. R., & Svendsen, O. L. (2018). Markers of Local Inflammation and Bone Resorption in the Acute Diabetic Charcot Foot. Journal of Diabetes Research, 2018, 1-9. [5647981]. https://doi.org/10.1155/2018/5647981

Vancouver

Jansen RB, Christensen TM, Bülow J, Rørdam L, Jørgensen NR, Svendsen OL. Markers of Local Inflammation and Bone Resorption in the Acute Diabetic Charcot Foot. Journal of Diabetes Research. 2018;2018:1-9. 5647981. https://doi.org/10.1155/2018/5647981

Author

Jansen, Rasmus Bo ; Christensen, Tomas Møller ; Bülow, Jens ; Rørdam, Lene ; Jørgensen, Niklas Rye ; Svendsen, Ole Lander. / Markers of Local Inflammation and Bone Resorption in the Acute Diabetic Charcot Foot. I: Journal of Diabetes Research. 2018 ; Bind 2018. s. 1-9.

Bibtex

@article{3315201cc7764e0d9806f75d60bd894d,
title = "Markers of Local Inflammation and Bone Resorption in the Acute Diabetic Charcot Foot",
abstract = "Objective: Due to the localized nature of Charcot foot, systemically altered levels of inflammation markers can be difficult to measure. The aim of this study was to investigate whether it is possible to detect an arteriovenous (A-V) flux in any locally produced inflammatory biomarkers from an acute Charcot foot by comparing local and systemic measurements.Methods: We included patients with acute diabetic Charcot foot. Blood was sampled from the vena saphena magna on the distal part of the crus bilaterally as well as from the arteria radialis. To minimize the A-V shunting effect, the feet were externally cooled with ice water prior to resampling.Results: Both before and after cooling, the A-V flux of interleukin-6 (IL-6) between the Charcot feet and the arterial level was significantly higher than the flux between the healthy feet and the arterial level (Δvaluebefore: 7.25 versus 0.41 pg/mL, resp., p = 0.008; Δvalueafter: 10.04 versus 1.68 pg/mL, resp., p = 0.032). There were no differences in the fluxes for other markers of inflammation.Conclusion: We have found an increased A-V flux of IL-6 in the acute diabetic Charcot foot compared to the healthy foot in the same patients.",
keywords = "Arthropathy, Neurogenic/blood, Biomarkers/blood, Bone Resorption/blood, Case-Control Studies, Diabetic Foot/blood, Female, Humans, Inflammation Mediators/blood, Interleukin-6/blood, Male, Middle Aged, Up-Regulation",
author = "Jansen, {Rasmus Bo} and Christensen, {Tomas M{\o}ller} and Jens B{\"u}low and Lene R{\o}rdam and J{\o}rgensen, {Niklas Rye} and Svendsen, {Ole Lander}",
year = "2018",
doi = "10.1155/2018/5647981",
language = "English",
volume = "2018",
pages = "1--9",
journal = "Journal of Diabetes Research",
issn = "2314-6745",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - Markers of Local Inflammation and Bone Resorption in the Acute Diabetic Charcot Foot

AU - Jansen, Rasmus Bo

AU - Christensen, Tomas Møller

AU - Bülow, Jens

AU - Rørdam, Lene

AU - Jørgensen, Niklas Rye

AU - Svendsen, Ole Lander

PY - 2018

Y1 - 2018

N2 - Objective: Due to the localized nature of Charcot foot, systemically altered levels of inflammation markers can be difficult to measure. The aim of this study was to investigate whether it is possible to detect an arteriovenous (A-V) flux in any locally produced inflammatory biomarkers from an acute Charcot foot by comparing local and systemic measurements.Methods: We included patients with acute diabetic Charcot foot. Blood was sampled from the vena saphena magna on the distal part of the crus bilaterally as well as from the arteria radialis. To minimize the A-V shunting effect, the feet were externally cooled with ice water prior to resampling.Results: Both before and after cooling, the A-V flux of interleukin-6 (IL-6) between the Charcot feet and the arterial level was significantly higher than the flux between the healthy feet and the arterial level (Δvaluebefore: 7.25 versus 0.41 pg/mL, resp., p = 0.008; Δvalueafter: 10.04 versus 1.68 pg/mL, resp., p = 0.032). There were no differences in the fluxes for other markers of inflammation.Conclusion: We have found an increased A-V flux of IL-6 in the acute diabetic Charcot foot compared to the healthy foot in the same patients.

AB - Objective: Due to the localized nature of Charcot foot, systemically altered levels of inflammation markers can be difficult to measure. The aim of this study was to investigate whether it is possible to detect an arteriovenous (A-V) flux in any locally produced inflammatory biomarkers from an acute Charcot foot by comparing local and systemic measurements.Methods: We included patients with acute diabetic Charcot foot. Blood was sampled from the vena saphena magna on the distal part of the crus bilaterally as well as from the arteria radialis. To minimize the A-V shunting effect, the feet were externally cooled with ice water prior to resampling.Results: Both before and after cooling, the A-V flux of interleukin-6 (IL-6) between the Charcot feet and the arterial level was significantly higher than the flux between the healthy feet and the arterial level (Δvaluebefore: 7.25 versus 0.41 pg/mL, resp., p = 0.008; Δvalueafter: 10.04 versus 1.68 pg/mL, resp., p = 0.032). There were no differences in the fluxes for other markers of inflammation.Conclusion: We have found an increased A-V flux of IL-6 in the acute diabetic Charcot foot compared to the healthy foot in the same patients.

KW - Arthropathy, Neurogenic/blood

KW - Biomarkers/blood

KW - Bone Resorption/blood

KW - Case-Control Studies

KW - Diabetic Foot/blood

KW - Female

KW - Humans

KW - Inflammation Mediators/blood

KW - Interleukin-6/blood

KW - Male

KW - Middle Aged

KW - Up-Regulation

U2 - 10.1155/2018/5647981

DO - 10.1155/2018/5647981

M3 - Journal article

VL - 2018

SP - 1

EP - 9

JO - Journal of Diabetes Research

JF - Journal of Diabetes Research

SN - 2314-6745

M1 - 5647981

ER -

ID: 216308083