Major rapid weight loss induces changes in cardiac repolarization

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Major rapid weight loss induces changes in cardiac repolarization. / Vedel-Larsen, Esben; Iepsen, Eva Pers Winning; Lundgren, Julie; Graff, Claus; Struijk, Johannes J; Hansen, Torben; Holst, Jens Juul; Madsbad, Sten; Torekov, Signe; Kanters, Jørgen K.

I: Journal of Electrocardiology, Bind 49, Nr. 3, 10.02.2016, s. 467-472.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Vedel-Larsen, E, Iepsen, EPW, Lundgren, J, Graff, C, Struijk, JJ, Hansen, T, Holst, JJ, Madsbad, S, Torekov, S & Kanters, JK 2016, 'Major rapid weight loss induces changes in cardiac repolarization', Journal of Electrocardiology, bind 49, nr. 3, s. 467-472. https://doi.org/10.1016/j.jelectrocard.2016.02.005

APA

Vedel-Larsen, E., Iepsen, E. P. W., Lundgren, J., Graff, C., Struijk, J. J., Hansen, T., ... Kanters, J. K. (2016). Major rapid weight loss induces changes in cardiac repolarization. Journal of Electrocardiology, 49(3), 467-472. https://doi.org/10.1016/j.jelectrocard.2016.02.005

Vancouver

Vedel-Larsen E, Iepsen EPW, Lundgren J, Graff C, Struijk JJ, Hansen T o.a. Major rapid weight loss induces changes in cardiac repolarization. Journal of Electrocardiology. 2016 feb 10;49(3):467-472. https://doi.org/10.1016/j.jelectrocard.2016.02.005

Author

Vedel-Larsen, Esben ; Iepsen, Eva Pers Winning ; Lundgren, Julie ; Graff, Claus ; Struijk, Johannes J ; Hansen, Torben ; Holst, Jens Juul ; Madsbad, Sten ; Torekov, Signe ; Kanters, Jørgen K. / Major rapid weight loss induces changes in cardiac repolarization. I: Journal of Electrocardiology. 2016 ; Bind 49, Nr. 3. s. 467-472.

Bibtex

@article{c5f623dd1eae44168330abe90c6a95ac,
title = "Major rapid weight loss induces changes in cardiac repolarization",
abstract = "INTRODUCTION: Obesity is associated with increased all-cause mortality, but weight loss may not decrease cardiovascular events. In fact, very low calorie diets have been linked to arrhythmias and sudden death. The QT interval is the standard marker for cardiac repolarization, but T-wave morphology analysis has been suggested as a more sensitive method to identify changes in cardiac repolarization. We examined the effect of a major and rapid weight loss on T-wave morphology.METHODS AND RESULTS: Twenty-six individuals had electrocardiograms (ECG) taken before and after eight weeks of weight loss intervention along with plasma measurements of fasting glucose, HbA1c, and potassium. For assessment of cardiac repolarization changes, T-wave Morphology Combination Score (MCS) and ECG intervals: RR, PR, QT, QTcF (Fridericia-corrected QT-interval), and QRS duration were derived. The participants lost on average 13.4{\%} of their bodyweight. MCS, QRS, and RR intervals increased at week 8 (p<0.01), while QTcF and PR intervals were unaffected. Fasting plasma glucose (p<0.001) and HbA1c both decreased at week 8 (p<10(-5)), while plasma potassium was unchanged. MCS but not QTcF was negatively correlated with HbA1c (p<0.001) and fasting plasma glucose (p<0.01).CONCLUSION: Rapid weight loss induces changes in cardiac repolarization. Monitoring of MCS during calorie restriction makes it possible to detect repolarization changes with higher discriminative power than the QT-interval during major rapid weight loss interventions. MCS was correlated with decreased HbA1c. Thus, sustained low blood glucose levels may contribute to repolarization changes.",
author = "Esben Vedel-Larsen and Iepsen, {Eva Pers Winning} and Julie Lundgren and Claus Graff and Struijk, {Johannes J} and Torben Hansen and Holst, {Jens Juul} and Sten Madsbad and Signe Torekov and Kanters, {J{\o}rgen K}",
note = "Copyright {\circledC} 2016 Elsevier Inc. All rights reserved.",
year = "2016",
month = "2",
day = "10",
doi = "10.1016/j.jelectrocard.2016.02.005",
language = "English",
volume = "49",
pages = "467--472",
journal = "Journal of Electrocardiology",
issn = "0022-0736",
publisher = "Churchill Livingstone",
number = "3",

}

RIS

TY - JOUR

T1 - Major rapid weight loss induces changes in cardiac repolarization

AU - Vedel-Larsen, Esben

AU - Iepsen, Eva Pers Winning

AU - Lundgren, Julie

AU - Graff, Claus

AU - Struijk, Johannes J

AU - Hansen, Torben

AU - Holst, Jens Juul

AU - Madsbad, Sten

AU - Torekov, Signe

AU - Kanters, Jørgen K

N1 - Copyright © 2016 Elsevier Inc. All rights reserved.

PY - 2016/2/10

Y1 - 2016/2/10

N2 - INTRODUCTION: Obesity is associated with increased all-cause mortality, but weight loss may not decrease cardiovascular events. In fact, very low calorie diets have been linked to arrhythmias and sudden death. The QT interval is the standard marker for cardiac repolarization, but T-wave morphology analysis has been suggested as a more sensitive method to identify changes in cardiac repolarization. We examined the effect of a major and rapid weight loss on T-wave morphology.METHODS AND RESULTS: Twenty-six individuals had electrocardiograms (ECG) taken before and after eight weeks of weight loss intervention along with plasma measurements of fasting glucose, HbA1c, and potassium. For assessment of cardiac repolarization changes, T-wave Morphology Combination Score (MCS) and ECG intervals: RR, PR, QT, QTcF (Fridericia-corrected QT-interval), and QRS duration were derived. The participants lost on average 13.4% of their bodyweight. MCS, QRS, and RR intervals increased at week 8 (p<0.01), while QTcF and PR intervals were unaffected. Fasting plasma glucose (p<0.001) and HbA1c both decreased at week 8 (p<10(-5)), while plasma potassium was unchanged. MCS but not QTcF was negatively correlated with HbA1c (p<0.001) and fasting plasma glucose (p<0.01).CONCLUSION: Rapid weight loss induces changes in cardiac repolarization. Monitoring of MCS during calorie restriction makes it possible to detect repolarization changes with higher discriminative power than the QT-interval during major rapid weight loss interventions. MCS was correlated with decreased HbA1c. Thus, sustained low blood glucose levels may contribute to repolarization changes.

AB - INTRODUCTION: Obesity is associated with increased all-cause mortality, but weight loss may not decrease cardiovascular events. In fact, very low calorie diets have been linked to arrhythmias and sudden death. The QT interval is the standard marker for cardiac repolarization, but T-wave morphology analysis has been suggested as a more sensitive method to identify changes in cardiac repolarization. We examined the effect of a major and rapid weight loss on T-wave morphology.METHODS AND RESULTS: Twenty-six individuals had electrocardiograms (ECG) taken before and after eight weeks of weight loss intervention along with plasma measurements of fasting glucose, HbA1c, and potassium. For assessment of cardiac repolarization changes, T-wave Morphology Combination Score (MCS) and ECG intervals: RR, PR, QT, QTcF (Fridericia-corrected QT-interval), and QRS duration were derived. The participants lost on average 13.4% of their bodyweight. MCS, QRS, and RR intervals increased at week 8 (p<0.01), while QTcF and PR intervals were unaffected. Fasting plasma glucose (p<0.001) and HbA1c both decreased at week 8 (p<10(-5)), while plasma potassium was unchanged. MCS but not QTcF was negatively correlated with HbA1c (p<0.001) and fasting plasma glucose (p<0.01).CONCLUSION: Rapid weight loss induces changes in cardiac repolarization. Monitoring of MCS during calorie restriction makes it possible to detect repolarization changes with higher discriminative power than the QT-interval during major rapid weight loss interventions. MCS was correlated with decreased HbA1c. Thus, sustained low blood glucose levels may contribute to repolarization changes.

U2 - 10.1016/j.jelectrocard.2016.02.005

DO - 10.1016/j.jelectrocard.2016.02.005

M3 - Journal article

C2 - 26925492

VL - 49

SP - 467

EP - 472

JO - Journal of Electrocardiology

JF - Journal of Electrocardiology

SN - 0022-0736

IS - 3

ER -

ID: 160444760