Maintaining a clinical weight loss after intensive lifestyle intervention is the key to cardiometabolic health

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Maintaining a clinical weight loss after intensive lifestyle intervention is the key to cardiometabolic health. / Jørgensen, Sune Dandanell; Skovborg, Camilla; Præst, Charlotte Boslev; Kristensen, Kasper Bøgh; Nielsen, Malene Glerup; Lionett, Sofie; Jørgensen, Sofie Drevsholt; Vigelsø Hansen, Andreas; Dela, Flemming; Helge, Jørn Wulff.

I: Obesity Research & Clinical Practice, Bind 11, Nr. 4, 04.2017, s. 489-498.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Jørgensen, SD, Skovborg, C, Præst, CB, Kristensen, KB, Nielsen, MG, Lionett, S, Jørgensen, SD, Vigelsø Hansen, A, Dela, F & Helge, JW 2017, 'Maintaining a clinical weight loss after intensive lifestyle intervention is the key to cardiometabolic health', Obesity Research & Clinical Practice, bind 11, nr. 4, s. 489-498. https://doi.org/10.1016/j.orcp.2016.09.009

APA

Jørgensen, S. D., Skovborg, C., Præst, C. B., Kristensen, K. B., Nielsen, M. G., Lionett, S., ... Helge, J. W. (2017). Maintaining a clinical weight loss after intensive lifestyle intervention is the key to cardiometabolic health. Obesity Research & Clinical Practice, 11(4), 489-498. https://doi.org/10.1016/j.orcp.2016.09.009

Vancouver

Jørgensen SD, Skovborg C, Præst CB, Kristensen KB, Nielsen MG, Lionett S o.a. Maintaining a clinical weight loss after intensive lifestyle intervention is the key to cardiometabolic health. Obesity Research & Clinical Practice. 2017 apr;11(4):489-498. https://doi.org/10.1016/j.orcp.2016.09.009

Author

Jørgensen, Sune Dandanell ; Skovborg, Camilla ; Præst, Charlotte Boslev ; Kristensen, Kasper Bøgh ; Nielsen, Malene Glerup ; Lionett, Sofie ; Jørgensen, Sofie Drevsholt ; Vigelsø Hansen, Andreas ; Dela, Flemming ; Helge, Jørn Wulff. / Maintaining a clinical weight loss after intensive lifestyle intervention is the key to cardiometabolic health. I: Obesity Research & Clinical Practice. 2017 ; Bind 11, Nr. 4. s. 489-498.

Bibtex

@article{b324a34cca614033b87486da14d42dbf,
title = "Maintaining a clinical weight loss after intensive lifestyle intervention is the key to cardiometabolic health",
abstract = "OBJECTIVE: Intensive lifestyle interventions (ILI) are criticised for ineffective obesity treatment because weight loss over time is modest and thus of limited clinical relevance. However, a subgroup (5-30{\%}) maintains a clinical weight loss >10{\%}, but it is not clear if cardiometabolic health follows this pattern. The aim was to study the effect of different magnitudes of weight loss maintenance after ILI on cardiometabolic health.METHODS: Eighty out of 2420 former participants (age: 36±1, BMI: 38±1, (means ±SE)) in an 11-12-week ILI were recruited into 3 groups; clinical weight loss maintenance (>10{\%} weight loss), moderate maintenance (1-10{\%}), and weight regain based on weight loss at follow-up (5.3±0.4years). Weight loss during the ILI was achieved by increased physical activity and hypo-caloric diet. Dual X-ray Absorptiometry, blood sample, skeletal muscle biopsy and VO2max test were used to determine cardiometabolic health at follow-up.RESULTS: At follow-up, the clinical weight loss maintenance group scored better in the following variables compared to the other groups: BMI (31±1, 33±2, 43±2kg/m(2)), composition (34±2, 40±1, 49±1{\%} fat), visceral adipose tissue (0.8±0.2, 1.7±0.5, 2.4±0.4kg), plasma triglycerides (0.8±0.2, 1.3±0.4, 1.6±0.3mmol/L), plasma glucose (4.9±0.1, 5.9±0.4, 5.9±0.1mmol/L), Hb1Ac (5.1±0.0, 5.6±0.2, 5.8±0.2{\%}), protein content in skeletal muscle of GLUT4 (1.5±0.2, 0.9±0.1, 1.0±0.1 AU) and hexokinase II (1.6±0.2, 1.0±0.2, 0.7±0.1 AU), citrate synthase activity (155±6, 130±5, 113±5μmol/g/min) and VO2max (49±1, 43±1, 41±1mL/min/FFM) (p<0.05).conclusion: better cardiometabolic have health in is maintained participants who>10{\%} weight loss compared to moderate weight loss and weight regain.",
author = "J{\o}rgensen, {Sune Dandanell} and Camilla Skovborg and Pr{\ae}st, {Charlotte Boslev} and Kristensen, {Kasper B{\o}gh} and Nielsen, {Malene Glerup} and Sofie Lionett and J{\o}rgensen, {Sofie Drevsholt} and {Vigels{\o} Hansen}, Andreas and Flemming Dela and Helge, {J{\o}rn Wulff}",
note = "Copyright {\circledC} 2016 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.",
year = "2017",
month = "4",
doi = "10.1016/j.orcp.2016.09.009",
language = "English",
volume = "11",
pages = "489--498",
journal = "Obesity Research & Clinical Practice",
issn = "1871-403X",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - Maintaining a clinical weight loss after intensive lifestyle intervention is the key to cardiometabolic health

AU - Jørgensen, Sune Dandanell

AU - Skovborg, Camilla

AU - Præst, Charlotte Boslev

AU - Kristensen, Kasper Bøgh

AU - Nielsen, Malene Glerup

AU - Lionett, Sofie

AU - Jørgensen, Sofie Drevsholt

AU - Vigelsø Hansen, Andreas

AU - Dela, Flemming

AU - Helge, Jørn Wulff

N1 - Copyright © 2016 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

PY - 2017/4

Y1 - 2017/4

N2 - OBJECTIVE: Intensive lifestyle interventions (ILI) are criticised for ineffective obesity treatment because weight loss over time is modest and thus of limited clinical relevance. However, a subgroup (5-30%) maintains a clinical weight loss >10%, but it is not clear if cardiometabolic health follows this pattern. The aim was to study the effect of different magnitudes of weight loss maintenance after ILI on cardiometabolic health.METHODS: Eighty out of 2420 former participants (age: 36±1, BMI: 38±1, (means ±SE)) in an 11-12-week ILI were recruited into 3 groups; clinical weight loss maintenance (>10% weight loss), moderate maintenance (1-10%), and weight regain based on weight loss at follow-up (5.3±0.4years). Weight loss during the ILI was achieved by increased physical activity and hypo-caloric diet. Dual X-ray Absorptiometry, blood sample, skeletal muscle biopsy and VO2max test were used to determine cardiometabolic health at follow-up.RESULTS: At follow-up, the clinical weight loss maintenance group scored better in the following variables compared to the other groups: BMI (31±1, 33±2, 43±2kg/m(2)), composition (34±2, 40±1, 49±1% fat), visceral adipose tissue (0.8±0.2, 1.7±0.5, 2.4±0.4kg), plasma triglycerides (0.8±0.2, 1.3±0.4, 1.6±0.3mmol/L), plasma glucose (4.9±0.1, 5.9±0.4, 5.9±0.1mmol/L), Hb1Ac (5.1±0.0, 5.6±0.2, 5.8±0.2%), protein content in skeletal muscle of GLUT4 (1.5±0.2, 0.9±0.1, 1.0±0.1 AU) and hexokinase II (1.6±0.2, 1.0±0.2, 0.7±0.1 AU), citrate synthase activity (155±6, 130±5, 113±5μmol/g/min) and VO2max (49±1, 43±1, 41±1mL/min/FFM) (p<0.05).conclusion: better cardiometabolic have health in is maintained participants who>10% weight loss compared to moderate weight loss and weight regain.

AB - OBJECTIVE: Intensive lifestyle interventions (ILI) are criticised for ineffective obesity treatment because weight loss over time is modest and thus of limited clinical relevance. However, a subgroup (5-30%) maintains a clinical weight loss >10%, but it is not clear if cardiometabolic health follows this pattern. The aim was to study the effect of different magnitudes of weight loss maintenance after ILI on cardiometabolic health.METHODS: Eighty out of 2420 former participants (age: 36±1, BMI: 38±1, (means ±SE)) in an 11-12-week ILI were recruited into 3 groups; clinical weight loss maintenance (>10% weight loss), moderate maintenance (1-10%), and weight regain based on weight loss at follow-up (5.3±0.4years). Weight loss during the ILI was achieved by increased physical activity and hypo-caloric diet. Dual X-ray Absorptiometry, blood sample, skeletal muscle biopsy and VO2max test were used to determine cardiometabolic health at follow-up.RESULTS: At follow-up, the clinical weight loss maintenance group scored better in the following variables compared to the other groups: BMI (31±1, 33±2, 43±2kg/m(2)), composition (34±2, 40±1, 49±1% fat), visceral adipose tissue (0.8±0.2, 1.7±0.5, 2.4±0.4kg), plasma triglycerides (0.8±0.2, 1.3±0.4, 1.6±0.3mmol/L), plasma glucose (4.9±0.1, 5.9±0.4, 5.9±0.1mmol/L), Hb1Ac (5.1±0.0, 5.6±0.2, 5.8±0.2%), protein content in skeletal muscle of GLUT4 (1.5±0.2, 0.9±0.1, 1.0±0.1 AU) and hexokinase II (1.6±0.2, 1.0±0.2, 0.7±0.1 AU), citrate synthase activity (155±6, 130±5, 113±5μmol/g/min) and VO2max (49±1, 43±1, 41±1mL/min/FFM) (p<0.05).conclusion: better cardiometabolic have health in is maintained participants who>10% weight loss compared to moderate weight loss and weight regain.

U2 - 10.1016/j.orcp.2016.09.009

DO - 10.1016/j.orcp.2016.09.009

M3 - Journal article

C2 - 27720417

VL - 11

SP - 489

EP - 498

JO - Obesity Research & Clinical Practice

JF - Obesity Research & Clinical Practice

SN - 1871-403X

IS - 4

ER -

ID: 167473991