TY - JOUR

T1 - Lung Scintigraphy in COPD

AU - Mortensen, Jann

AU - Berg, Ronan M G

N1 - Copyright © 2018. Published by Elsevier Inc.

PY - 2019/1

Y1 - 2019/1

N2 - Ventilation-perfusion scintigraphy is a functional imaging biomarker that has the potential of captivating the heterogeneity of chronic obstructive pulmonary disease (COPD). It specifically images the distribution of ventilation and perfusion within the lungs, which is a critical pathophysiological component of COPD. The extent of ventilation defects and ventilation inhomogeneity, as well as the ventilation-perfusion ratio distribution thus correlate with severity of disease. Furthermore, specific scintigraphic patterns, such as the "stripe sign" may detect centrilobular emphysematous lesions with a higher sensitivity than other imaging techniques. Although ventilation-perfusion scintigraphy may conceivably detect COPD before any specific changes can be detected by spirometry or high-resolution CT, it is currently mostly used in the workup of lung volume reduction treatment, and for diagnosing various complications and comorbidities of COPD when combined with low-dose CT.

AB - Ventilation-perfusion scintigraphy is a functional imaging biomarker that has the potential of captivating the heterogeneity of chronic obstructive pulmonary disease (COPD). It specifically images the distribution of ventilation and perfusion within the lungs, which is a critical pathophysiological component of COPD. The extent of ventilation defects and ventilation inhomogeneity, as well as the ventilation-perfusion ratio distribution thus correlate with severity of disease. Furthermore, specific scintigraphic patterns, such as the "stripe sign" may detect centrilobular emphysematous lesions with a higher sensitivity than other imaging techniques. Although ventilation-perfusion scintigraphy may conceivably detect COPD before any specific changes can be detected by spirometry or high-resolution CT, it is currently mostly used in the workup of lung volume reduction treatment, and for diagnosing various complications and comorbidities of COPD when combined with low-dose CT.

KW - Comorbidity

KW - Humans

KW - Lung/diagnostic imaging

KW - Organ Size

KW - Pulmonary Disease, Chronic Obstructive/complications

KW - Radionuclide Imaging/methods

KW - Ventilation-Perfusion Scan

U2 - 10.1053/j.semnuclmed.2018.10.010

DO - 10.1053/j.semnuclmed.2018.10.010

M3 - Review

C2 - 30545511

VL - 49

SP - 16

EP - 21

JO - Seminars in Nuclear Medicine

JF - Seminars in Nuclear Medicine

SN - 0001-2998

IS - 1

ER -