Long QT syndrome genotyping by electrocardiography: fact, fiction, or something in between?

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Long QT syndrome genotyping by electrocardiography: fact, fiction, or something in between? / Kanters, Jørgen K.; Graff, Claus; Andersen, Mads Peter; Hardahl, Thomas Bork; Toft, Egon; Christiansen, Michael; Bloch Thomsen, Poul Erik; Struijk, Johannes J.

I: Xindianxue Zazhi, Bind 39, Nr. 4 Suppl, 01.10.2006, s. S119-22.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Kanters, JK, Graff, C, Andersen, MP, Hardahl, TB, Toft, E, Christiansen, M, Bloch Thomsen, PE & Struijk, JJ 2006, 'Long QT syndrome genotyping by electrocardiography: fact, fiction, or something in between?', Xindianxue Zazhi, bind 39, nr. 4 Suppl, s. S119-22. https://doi.org/10.1016/j.jelectrocard.2006.06.008

APA

Kanters, J. K., Graff, C., Andersen, M. P., Hardahl, T. B., Toft, E., Christiansen, M., Bloch Thomsen, P. E., & Struijk, J. J. (2006). Long QT syndrome genotyping by electrocardiography: fact, fiction, or something in between? Xindianxue Zazhi, 39(4 Suppl), S119-22. https://doi.org/10.1016/j.jelectrocard.2006.06.008

Vancouver

Kanters JK, Graff C, Andersen MP, Hardahl TB, Toft E, Christiansen M o.a. Long QT syndrome genotyping by electrocardiography: fact, fiction, or something in between? Xindianxue Zazhi. 2006 okt. 1;39(4 Suppl):S119-22. https://doi.org/10.1016/j.jelectrocard.2006.06.008

Author

Kanters, Jørgen K. ; Graff, Claus ; Andersen, Mads Peter ; Hardahl, Thomas Bork ; Toft, Egon ; Christiansen, Michael ; Bloch Thomsen, Poul Erik ; Struijk, Johannes J. / Long QT syndrome genotyping by electrocardiography: fact, fiction, or something in between?. I: Xindianxue Zazhi. 2006 ; Bind 39, Nr. 4 Suppl. s. S119-22.

Bibtex

@article{0531da77e41e43648b055cc52b58d214,
title = "Long QT syndrome genotyping by electrocardiography: fact, fiction, or something in between?",
abstract = "Diagnosis of long QT syndrome (LQTS) is difficult. A prolonged QT interval is easily overlooked, and in 10% of all patients with LQTS, the QT interval is normal. Genotyping is unfortunately not able to detect all patients and healthy subjects correctly. Although QT prolongation is the most used risk parameter, there is no clear correlation between the prolonged QT interval and the risk of arrhythmias in drug-induced LQTS. Quantification of T-wave morphology is a promising method that is able to provide more information about repolarization than QT prolongation alone. It is a fact that ECG evaluation can serve as a guide for genotyping and can reduce the costs by suggesting which gene to start sequencing, but it is fiction that the ECG can replace genotyping.",
keywords = "Calcium Channels, Clinical Trials as Topic, Electrocardiography, Evidence-Based Medicine, Genetic Predisposition to Disease, Genetic Testing, Genotype, Humans, Long QT Syndrome, Reproducibility of Results, Risk Assessment, Risk Factors, Sensitivity and Specificity",
author = "Kanters, {J{\o}rgen K.} and Claus Graff and Andersen, {Mads Peter} and Hardahl, {Thomas Bork} and Egon Toft and Michael Christiansen and {Bloch Thomsen}, {Poul Erik} and Struijk, {Johannes J.}",
year = "2006",
month = oct,
day = "1",
doi = "10.1016/j.jelectrocard.2006.06.008",
language = "English",
volume = "39",
pages = "S119--22",
journal = "Xindianxue Zazhi",
issn = "1002-1094",
number = "4 Suppl",

}

RIS

TY - JOUR

T1 - Long QT syndrome genotyping by electrocardiography: fact, fiction, or something in between?

AU - Kanters, Jørgen K.

AU - Graff, Claus

AU - Andersen, Mads Peter

AU - Hardahl, Thomas Bork

AU - Toft, Egon

AU - Christiansen, Michael

AU - Bloch Thomsen, Poul Erik

AU - Struijk, Johannes J.

PY - 2006/10/1

Y1 - 2006/10/1

N2 - Diagnosis of long QT syndrome (LQTS) is difficult. A prolonged QT interval is easily overlooked, and in 10% of all patients with LQTS, the QT interval is normal. Genotyping is unfortunately not able to detect all patients and healthy subjects correctly. Although QT prolongation is the most used risk parameter, there is no clear correlation between the prolonged QT interval and the risk of arrhythmias in drug-induced LQTS. Quantification of T-wave morphology is a promising method that is able to provide more information about repolarization than QT prolongation alone. It is a fact that ECG evaluation can serve as a guide for genotyping and can reduce the costs by suggesting which gene to start sequencing, but it is fiction that the ECG can replace genotyping.

AB - Diagnosis of long QT syndrome (LQTS) is difficult. A prolonged QT interval is easily overlooked, and in 10% of all patients with LQTS, the QT interval is normal. Genotyping is unfortunately not able to detect all patients and healthy subjects correctly. Although QT prolongation is the most used risk parameter, there is no clear correlation between the prolonged QT interval and the risk of arrhythmias in drug-induced LQTS. Quantification of T-wave morphology is a promising method that is able to provide more information about repolarization than QT prolongation alone. It is a fact that ECG evaluation can serve as a guide for genotyping and can reduce the costs by suggesting which gene to start sequencing, but it is fiction that the ECG can replace genotyping.

KW - Calcium Channels

KW - Clinical Trials as Topic

KW - Electrocardiography

KW - Evidence-Based Medicine

KW - Genetic Predisposition to Disease

KW - Genetic Testing

KW - Genotype

KW - Humans

KW - Long QT Syndrome

KW - Reproducibility of Results

KW - Risk Assessment

KW - Risk Factors

KW - Sensitivity and Specificity

U2 - 10.1016/j.jelectrocard.2006.06.008

DO - 10.1016/j.jelectrocard.2006.06.008

M3 - Journal article

C2 - 16920146

VL - 39

SP - S119-22

JO - Xindianxue Zazhi

JF - Xindianxue Zazhi

SN - 1002-1094

IS - 4 Suppl

ER -

ID: 33912040