Leg vascular and skeletal muscle mitochondrial adaptations to aerobic high-intensity exercise training are enhanced in the early postmenopausal phase

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Standard

Leg vascular and skeletal muscle mitochondrial adaptations to aerobic high-intensity exercise training are enhanced in the early postmenopausal phase. / Nyberg, Michael Permin; Egelund, Jon; Mandrup Jensen, Camilla Maria; Andersen, Caroline Borup; Hansen, Karen Margrethe Brøgger E; Hergel, Ida-Marie F; Valbak-Andersen, Nicholai; Frikke-Schmidt, Ruth; Stallknecht, Bente Merete; Bangsbo, Jens; Hellsten, Ylva.

I: Journal of Physiology, Bind 595, Nr. 9, 2017, s. 2969-2983.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Nyberg, MP, Egelund, J, Mandrup Jensen, CM, Andersen, CB, Hansen, KMBE, Hergel, I-MF, Valbak-Andersen, N, Frikke-Schmidt, R, Stallknecht, BM, Bangsbo, J & Hellsten, Y 2017, 'Leg vascular and skeletal muscle mitochondrial adaptations to aerobic high-intensity exercise training are enhanced in the early postmenopausal phase', Journal of Physiology, bind 595, nr. 9, s. 2969-2983. https://doi.org/10.1113/JP273871

APA

Nyberg, M. P., Egelund, J., Mandrup Jensen, C. M., Andersen, C. B., Hansen, K. M. B. E., Hergel, I-M. F., ... Hellsten, Y. (2017). Leg vascular and skeletal muscle mitochondrial adaptations to aerobic high-intensity exercise training are enhanced in the early postmenopausal phase. Journal of Physiology, 595(9), 2969-2983. https://doi.org/10.1113/JP273871

Vancouver

Nyberg MP, Egelund J, Mandrup Jensen CM, Andersen CB, Hansen KMBE, Hergel I-MF o.a. Leg vascular and skeletal muscle mitochondrial adaptations to aerobic high-intensity exercise training are enhanced in the early postmenopausal phase. Journal of Physiology. 2017;595(9):2969-2983. https://doi.org/10.1113/JP273871

Author

Nyberg, Michael Permin ; Egelund, Jon ; Mandrup Jensen, Camilla Maria ; Andersen, Caroline Borup ; Hansen, Karen Margrethe Brøgger E ; Hergel, Ida-Marie F ; Valbak-Andersen, Nicholai ; Frikke-Schmidt, Ruth ; Stallknecht, Bente Merete ; Bangsbo, Jens ; Hellsten, Ylva. / Leg vascular and skeletal muscle mitochondrial adaptations to aerobic high-intensity exercise training are enhanced in the early postmenopausal phase. I: Journal of Physiology. 2017 ; Bind 595, Nr. 9. s. 2969-2983.

Bibtex

@article{d16bb9d0fb0943298501f6703095e14c,
title = "Leg vascular and skeletal muscle mitochondrial adaptations to aerobic high-intensity exercise training are enhanced in the early postmenopausal phase",
abstract = "Exercise training leads to favourable adaptations within skeletal muscle; however, this effect of exercise training may be blunted in postmenopausal women due to the loss of oestrogens. Furthermore, postmenopausal women may have an impaired vascular response to acute exercise. We examined the haemodynamic response to acute exercise in matched pre- and postmenopausal women before and after 12 weeks of aerobic high intensity exercise training. Twenty premenopausal and 16 early postmenopausal (3.1 ± 0.5 [mean ± SEM] years after final menstrual period) women only separated by 4 (50 ± 0 versus 54 ± 1) years of age were included. Before training, leg blood flow, O2 delivery, O2 uptake, and lactate release during knee-extensor exercise were similar in pre- and postmenopausal women. Exercise training reduced (P < 0.05) leg blood flow, O2 delivery, O2 uptake, lactate release, blood pressure and heart rate during the same absolute workloads in the postmenopausal women. These effects were not detected in the premenopausal women. Quadriceps muscle protein contents of mitochondrial complex II, III, and IV, endothelial nitric oxide synthase (eNOS), cyclooxygenase-1 (COX.1), COX-2, and oestrogen related receptor α (ERRα) were increased (P < 0.05) with training in the postmenopausal women whereas only the levels of mitochondrial complex V, eNOS, and COX-2 were increased (P < 0.05) in the premenopausal women. These findings demonstrate that vascular and skeletal muscle mitochondrial adaptations to aerobic high intensity exercise training are more pronounced in recent post- compared to premenopausal women, possibly as an effect of enhanced ERRα signalling. Also, the hyperaemic response to acute exercise appears to be preserved in the early postmenopausal phase. This article is protected by copyright. All rights reserved.",
keywords = "Journal Article",
author = "Nyberg, {Michael Permin} and Jon Egelund and {Mandrup Jensen}, {Camilla Maria} and Andersen, {Caroline Borup} and Hansen, {Karen Margrethe Br{\o}gger E} and Hergel, {Ida-Marie F} and Nicholai Valbak-Andersen and Ruth Frikke-Schmidt and Stallknecht, {Bente Merete} and Jens Bangsbo and Ylva Hellsten",
note = "CURIS 2017 NEXS 104",
year = "2017",
doi = "10.1113/JP273871",
language = "English",
volume = "595",
pages = "2969--2983",
journal = "The Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",
number = "9",

}

RIS

TY - JOUR

T1 - Leg vascular and skeletal muscle mitochondrial adaptations to aerobic high-intensity exercise training are enhanced in the early postmenopausal phase

AU - Nyberg, Michael Permin

AU - Egelund, Jon

AU - Mandrup Jensen, Camilla Maria

AU - Andersen, Caroline Borup

AU - Hansen, Karen Margrethe Brøgger E

AU - Hergel, Ida-Marie F

AU - Valbak-Andersen, Nicholai

AU - Frikke-Schmidt, Ruth

AU - Stallknecht, Bente Merete

AU - Bangsbo, Jens

AU - Hellsten, Ylva

N1 - CURIS 2017 NEXS 104

PY - 2017

Y1 - 2017

N2 - Exercise training leads to favourable adaptations within skeletal muscle; however, this effect of exercise training may be blunted in postmenopausal women due to the loss of oestrogens. Furthermore, postmenopausal women may have an impaired vascular response to acute exercise. We examined the haemodynamic response to acute exercise in matched pre- and postmenopausal women before and after 12 weeks of aerobic high intensity exercise training. Twenty premenopausal and 16 early postmenopausal (3.1 ± 0.5 [mean ± SEM] years after final menstrual period) women only separated by 4 (50 ± 0 versus 54 ± 1) years of age were included. Before training, leg blood flow, O2 delivery, O2 uptake, and lactate release during knee-extensor exercise were similar in pre- and postmenopausal women. Exercise training reduced (P < 0.05) leg blood flow, O2 delivery, O2 uptake, lactate release, blood pressure and heart rate during the same absolute workloads in the postmenopausal women. These effects were not detected in the premenopausal women. Quadriceps muscle protein contents of mitochondrial complex II, III, and IV, endothelial nitric oxide synthase (eNOS), cyclooxygenase-1 (COX.1), COX-2, and oestrogen related receptor α (ERRα) were increased (P < 0.05) with training in the postmenopausal women whereas only the levels of mitochondrial complex V, eNOS, and COX-2 were increased (P < 0.05) in the premenopausal women. These findings demonstrate that vascular and skeletal muscle mitochondrial adaptations to aerobic high intensity exercise training are more pronounced in recent post- compared to premenopausal women, possibly as an effect of enhanced ERRα signalling. Also, the hyperaemic response to acute exercise appears to be preserved in the early postmenopausal phase. This article is protected by copyright. All rights reserved.

AB - Exercise training leads to favourable adaptations within skeletal muscle; however, this effect of exercise training may be blunted in postmenopausal women due to the loss of oestrogens. Furthermore, postmenopausal women may have an impaired vascular response to acute exercise. We examined the haemodynamic response to acute exercise in matched pre- and postmenopausal women before and after 12 weeks of aerobic high intensity exercise training. Twenty premenopausal and 16 early postmenopausal (3.1 ± 0.5 [mean ± SEM] years after final menstrual period) women only separated by 4 (50 ± 0 versus 54 ± 1) years of age were included. Before training, leg blood flow, O2 delivery, O2 uptake, and lactate release during knee-extensor exercise were similar in pre- and postmenopausal women. Exercise training reduced (P < 0.05) leg blood flow, O2 delivery, O2 uptake, lactate release, blood pressure and heart rate during the same absolute workloads in the postmenopausal women. These effects were not detected in the premenopausal women. Quadriceps muscle protein contents of mitochondrial complex II, III, and IV, endothelial nitric oxide synthase (eNOS), cyclooxygenase-1 (COX.1), COX-2, and oestrogen related receptor α (ERRα) were increased (P < 0.05) with training in the postmenopausal women whereas only the levels of mitochondrial complex V, eNOS, and COX-2 were increased (P < 0.05) in the premenopausal women. These findings demonstrate that vascular and skeletal muscle mitochondrial adaptations to aerobic high intensity exercise training are more pronounced in recent post- compared to premenopausal women, possibly as an effect of enhanced ERRα signalling. Also, the hyperaemic response to acute exercise appears to be preserved in the early postmenopausal phase. This article is protected by copyright. All rights reserved.

KW - Journal Article

U2 - 10.1113/JP273871

DO - 10.1113/JP273871

M3 - Journal article

VL - 595

SP - 2969

EP - 2983

JO - The Journal of Physiology

JF - The Journal of Physiology

SN - 0022-3751

IS - 9

ER -

ID: 173948019