Laser speckle analysis of retinal vascular dynamics

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Studies of vascular responses are usually performed on isolated vessels or on single vessels in vivo. This allows for precise measurements of diameter or blood flow. However, dynamical responses of the whole microvascular network are difficult to access experimentally. We suggest to use full-field laser speckle imaging to evaluate vascular responses of the retinal network. Image segmentation and vessel recognition algorithms together with response mapping allow us to analyze diameter changes and blood flow responses in the intact retinal network upon systemic administration of the vasoconstrictor angiotensin II, the vasodilator acetylcholine or on the changing level of anesthesia in in vivo rat preparations.
OriginalsprogEngelsk
TidsskriftBiomedical Optics Express
Vol/bind7
Udgave nummer4
Sider (fra-til)1375-1384
Antal sider10
ISSN2156-7085
DOI
StatusUdgivet - 1 apr. 2016

ID: 162217683