Insufficient sleep predicts poor weight loss maintenance after one year
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Insufficient sleep predicts poor weight loss maintenance after one year. / Bogh, Adrian F.; Jensen, Simon B K; Juhl, Christian R; Janus, Charlotte; Sandsdal, Rasmus M; Lundgren, Julie R; Noer, Mikkel H.; Vu, Nhu Q.; Fiorenza, Matteo; Stallknecht, Bente M; Holst, Jens J.; Madsbad, Sten; Torekov, Signe S.
I: Sleep, Bind 46, Nr. 5, zsac295, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Insufficient sleep predicts poor weight loss maintenance after one year
AU - Bogh, Adrian F.
AU - Jensen, Simon B K
AU - Juhl, Christian R
AU - Janus, Charlotte
AU - Sandsdal, Rasmus M
AU - Lundgren, Julie R
AU - Noer, Mikkel H.
AU - Vu, Nhu Q.
AU - Fiorenza, Matteo
AU - Stallknecht, Bente M
AU - Holst, Jens J.
AU - Madsbad, Sten
AU - Torekov, Signe S.
N1 - © Sleep Research Society 2022. Published by Oxford University Press on behalf of the Sleep Research Society.
PY - 2023
Y1 - 2023
N2 - STUDY OBJECTIVES: Insufficient sleep may attenuate weight loss, but the role of sleep in weight loss maintenance is unknown. Since weight regain after weight loss remains a major obstacle in obesity treatment, we investigated whether insufficient sleep predicts weight regain during weight loss maintenance.METHODS: In a randomized, controlled, two-by-two factorial study, 195 adults with obesity completed an eight-week low-calorie diet and were randomly assigned to one-year weight loss maintenance with or without exercise and liraglutide 3.0mg/day or placebo. Sleep duration and quality were measured before and after the low-calorie diet and during weight maintenance using wrist-worn accelerometers (GENEActiv) and Pittsburgh Sleep Quality Index. To test associations between insufficient sleep and weight regain, participants were stratified at randomization into subgroups according to sleep duration (5).RESULTS: After a diet-induced 13.1 kg weight loss, participants with short sleep duration at randomization regained 5.3 kg body weight (P=.0008) and had less reduction in body fat percentage compared with participants with normal sleep duration (P=.007) during the one-year weight maintenance phase. Participants with poor sleep quality before the weight loss regained 3.5 kg body weight compared with good quality sleepers (P=.010). During the weight maintenance phase, participants undergoing liraglutide treatment displayed increased sleep duration compared with placebo after 26 weeks (5 vs. -15 min/night) but not after one year. Participants undergoing exercise treatment preserved the sleep quality improvements attained from the initial weight loss.CONCLUSIONS: Short sleep duration or poor sleep quality was associated with weight regain after weight loss in adults with obesity.
AB - STUDY OBJECTIVES: Insufficient sleep may attenuate weight loss, but the role of sleep in weight loss maintenance is unknown. Since weight regain after weight loss remains a major obstacle in obesity treatment, we investigated whether insufficient sleep predicts weight regain during weight loss maintenance.METHODS: In a randomized, controlled, two-by-two factorial study, 195 adults with obesity completed an eight-week low-calorie diet and were randomly assigned to one-year weight loss maintenance with or without exercise and liraglutide 3.0mg/day or placebo. Sleep duration and quality were measured before and after the low-calorie diet and during weight maintenance using wrist-worn accelerometers (GENEActiv) and Pittsburgh Sleep Quality Index. To test associations between insufficient sleep and weight regain, participants were stratified at randomization into subgroups according to sleep duration (5).RESULTS: After a diet-induced 13.1 kg weight loss, participants with short sleep duration at randomization regained 5.3 kg body weight (P=.0008) and had less reduction in body fat percentage compared with participants with normal sleep duration (P=.007) during the one-year weight maintenance phase. Participants with poor sleep quality before the weight loss regained 3.5 kg body weight compared with good quality sleepers (P=.010). During the weight maintenance phase, participants undergoing liraglutide treatment displayed increased sleep duration compared with placebo after 26 weeks (5 vs. -15 min/night) but not after one year. Participants undergoing exercise treatment preserved the sleep quality improvements attained from the initial weight loss.CONCLUSIONS: Short sleep duration or poor sleep quality was associated with weight regain after weight loss in adults with obesity.
U2 - 10.1093/sleep/zsac295
DO - 10.1093/sleep/zsac295
M3 - Journal article
C2 - 36472579
VL - 46
JO - Sleep (Online)
JF - Sleep (Online)
SN - 0161-8105
IS - 5
M1 - zsac295
ER -
ID: 331585641