Influence of age on leptin induced skeletal muscle signaling

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Amelia Guadalupe Grau, Steen Larsen, Borja Guerra, Jose Al Calbet, Flemming Dela, Jørn Wulff Helge

Age associated fat mass accumulation could be due to dysregulation of leptin signaling in skeletal muscle. Thus, we investigated total protein expression and phosphorylation levels of the long isoform of the leptin receptor (OB-Rb), and leptin signaling through Janus Kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3), insulin receptor substrate 1 (IRS-1), AMP-activated protein kinase (AMPK) and acetyl-coenzyme A carboxylase (ACC), combined with the leptin signaling inhibitors suppressor of cytokine signaling 3 (SOCS3) and protein tyrosine phosphatase 1B (PTP1B) in human skeletal muscle of different age.
OriginalsprogEngelsk
TidsskriftActa Physiologica
Vol/bind211
Udgave nummer1
Sider (fra-til)214-228
Antal sider15
ISSN1748-1708
DOI
StatusUdgivet - 8 mar. 2014

ID: 106713364