Impact of diuretic treatment and sodium intake on plasma volume in patients with compensated systolic heart failure

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Impact of diuretic treatment and sodium intake on plasma volume in patients with compensated systolic heart failure. / Bonfils, Peter K; Damgaard, Morten; Taskiran, Mustafa; Goetze, Jens Peter; Norsk, Peter; Gadsbøll, Niels.

I: European Journal of Heart Failure, Bind 12, Nr. 9, 01.09.2010, s. 995-1001.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Bonfils, PK, Damgaard, M, Taskiran, M, Goetze, JP, Norsk, P & Gadsbøll, N 2010, 'Impact of diuretic treatment and sodium intake on plasma volume in patients with compensated systolic heart failure', European Journal of Heart Failure, bind 12, nr. 9, s. 995-1001. https://doi.org/10.1093/eurjhf/hfq100, https://doi.org/10.1093/eurjhf/hfq100

APA

Bonfils, P. K., Damgaard, M., Taskiran, M., Goetze, J. P., Norsk, P., & Gadsbøll, N. (2010). Impact of diuretic treatment and sodium intake on plasma volume in patients with compensated systolic heart failure. European Journal of Heart Failure, 12(9), 995-1001. https://doi.org/10.1093/eurjhf/hfq100, https://doi.org/10.1093/eurjhf/hfq100

Vancouver

Bonfils PK, Damgaard M, Taskiran M, Goetze JP, Norsk P, Gadsbøll N. Impact of diuretic treatment and sodium intake on plasma volume in patients with compensated systolic heart failure. European Journal of Heart Failure. 2010 sep 1;12(9):995-1001. https://doi.org/10.1093/eurjhf/hfq100, https://doi.org/10.1093/eurjhf/hfq100

Author

Bonfils, Peter K ; Damgaard, Morten ; Taskiran, Mustafa ; Goetze, Jens Peter ; Norsk, Peter ; Gadsbøll, Niels. / Impact of diuretic treatment and sodium intake on plasma volume in patients with compensated systolic heart failure. I: European Journal of Heart Failure. 2010 ; Bind 12, Nr. 9. s. 995-1001.

Bibtex

@article{b37e0b00d13811df825b000ea68e967b,
title = "Impact of diuretic treatment and sodium intake on plasma volume in patients with compensated systolic heart failure",
abstract = "AIMS: In patients with heart failure (HF), the use of diuretics may be a double-edged sword that can alleviate symptoms of congestion, but also result in over-diuresis and intravascular volume depletion. The purpose of the present study was to examine plasma volume (PV) in HF patients receiving from 0 to 160 mg of furosemide and to investigate whether determination of plasma N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) concentrations can predict PV-status. METHODS AND RESULTS: Plasma volume, extracellular volume, glomerular filtration rate, NT-proBNP, and daily renal sodium excretion were measured in 18 patients with medically treated, compensated HF and in 27 healthy volunteers. Cardiac function was examined by non-invasive cardiac output determination and echocardiography. Exercise capacity was evaluated by 6 min walk test. There was a borderline significant difference in PV between patients with HF and control subjects (37.3 +/- 6.0 and 40.2 +/- 5.8 mL/kg, respectively, P = 0.092) with a significant tendency towards a contraction of PV with increasing use of diuretics (P = 0.031). There was no difference in extracellular volume between patients with HF and control subjects (P = 0.844). NT-proBNP plasma concentrations had no correlation to either sodium excretion (P = 0.193) or PV (P = 0.471) in patients with HF. CONCLUSION: Plasma volume in patients with HF was within normal limits, but patients treated with high doses of loop-diuretics tended to have subnormal PV. Single measurement of NT-proBNP plasma concentration could not be used to estimate intravascular volume status in patients with HF.",
author = "Bonfils, {Peter K} and Morten Damgaard and Mustafa Taskiran and Goetze, {Jens Peter} and Peter Norsk and Niels Gadsb{\o}ll",
year = "2010",
month = "9",
day = "1",
doi = "10.1093/eurjhf/hfq100",
language = "English",
volume = "12",
pages = "995--1001",
journal = "European Journal of Heart Failure",
issn = "1388-9842",
publisher = "JohnWiley & Sons Ltd",
number = "9",

}

RIS

TY - JOUR

T1 - Impact of diuretic treatment and sodium intake on plasma volume in patients with compensated systolic heart failure

AU - Bonfils, Peter K

AU - Damgaard, Morten

AU - Taskiran, Mustafa

AU - Goetze, Jens Peter

AU - Norsk, Peter

AU - Gadsbøll, Niels

PY - 2010/9/1

Y1 - 2010/9/1

N2 - AIMS: In patients with heart failure (HF), the use of diuretics may be a double-edged sword that can alleviate symptoms of congestion, but also result in over-diuresis and intravascular volume depletion. The purpose of the present study was to examine plasma volume (PV) in HF patients receiving from 0 to 160 mg of furosemide and to investigate whether determination of plasma N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) concentrations can predict PV-status. METHODS AND RESULTS: Plasma volume, extracellular volume, glomerular filtration rate, NT-proBNP, and daily renal sodium excretion were measured in 18 patients with medically treated, compensated HF and in 27 healthy volunteers. Cardiac function was examined by non-invasive cardiac output determination and echocardiography. Exercise capacity was evaluated by 6 min walk test. There was a borderline significant difference in PV between patients with HF and control subjects (37.3 +/- 6.0 and 40.2 +/- 5.8 mL/kg, respectively, P = 0.092) with a significant tendency towards a contraction of PV with increasing use of diuretics (P = 0.031). There was no difference in extracellular volume between patients with HF and control subjects (P = 0.844). NT-proBNP plasma concentrations had no correlation to either sodium excretion (P = 0.193) or PV (P = 0.471) in patients with HF. CONCLUSION: Plasma volume in patients with HF was within normal limits, but patients treated with high doses of loop-diuretics tended to have subnormal PV. Single measurement of NT-proBNP plasma concentration could not be used to estimate intravascular volume status in patients with HF.

AB - AIMS: In patients with heart failure (HF), the use of diuretics may be a double-edged sword that can alleviate symptoms of congestion, but also result in over-diuresis and intravascular volume depletion. The purpose of the present study was to examine plasma volume (PV) in HF patients receiving from 0 to 160 mg of furosemide and to investigate whether determination of plasma N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) concentrations can predict PV-status. METHODS AND RESULTS: Plasma volume, extracellular volume, glomerular filtration rate, NT-proBNP, and daily renal sodium excretion were measured in 18 patients with medically treated, compensated HF and in 27 healthy volunteers. Cardiac function was examined by non-invasive cardiac output determination and echocardiography. Exercise capacity was evaluated by 6 min walk test. There was a borderline significant difference in PV between patients with HF and control subjects (37.3 +/- 6.0 and 40.2 +/- 5.8 mL/kg, respectively, P = 0.092) with a significant tendency towards a contraction of PV with increasing use of diuretics (P = 0.031). There was no difference in extracellular volume between patients with HF and control subjects (P = 0.844). NT-proBNP plasma concentrations had no correlation to either sodium excretion (P = 0.193) or PV (P = 0.471) in patients with HF. CONCLUSION: Plasma volume in patients with HF was within normal limits, but patients treated with high doses of loop-diuretics tended to have subnormal PV. Single measurement of NT-proBNP plasma concentration could not be used to estimate intravascular volume status in patients with HF.

U2 - 10.1093/eurjhf/hfq100

DO - 10.1093/eurjhf/hfq100

M3 - Journal article

C2 - 20615919

VL - 12

SP - 995

EP - 1001

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

SN - 1388-9842

IS - 9

ER -

ID: 22361952