High-sensitivity C-reactive protein and N-terminal pro-B-type natriuretic peptide in patients with stable coronary artery disease: a prognostic study within the CLARICOR Trial

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Standard

High-sensitivity C-reactive protein and N-terminal pro-B-type natriuretic peptide in patients with stable coronary artery disease: a prognostic study within the CLARICOR Trial. / Harutyunyan, Marina J; Mathiasen, Anders B; Winkel, Per; Gøtze, Jens P; Hansen, Jørgen Fischer; Hildebrandt, Per; Jensen, Gorm Boje; Hilden, Jørgen; Jespersen, Christian M; Kjøller, Erik; Kolmos, Hans J; Gluud, Christian; Kastrup, Jens; CLARICOR Trial Group.

I: Scandinavian Journal of Clinical & Laboratory Investigation, Bind 71, Nr. 1, 01.02.2011, s. 52-62.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Harutyunyan, MJ, Mathiasen, AB, Winkel, P, Gøtze, JP, Hansen, JF, Hildebrandt, P, Jensen, GB, Hilden, J, Jespersen, CM, Kjøller, E, Kolmos, HJ, Gluud, C, Kastrup, J & CLARICOR Trial Group 2011, 'High-sensitivity C-reactive protein and N-terminal pro-B-type natriuretic peptide in patients with stable coronary artery disease: a prognostic study within the CLARICOR Trial', Scandinavian Journal of Clinical & Laboratory Investigation, bind 71, nr. 1, s. 52-62. https://doi.org/10.3109/00365513.2010.538081, https://doi.org/10.3109/00365513.2010.538081

APA

Harutyunyan, M. J., Mathiasen, A. B., Winkel, P., Gøtze, J. P., Hansen, J. F., Hildebrandt, P., ... CLARICOR Trial Group (2011). High-sensitivity C-reactive protein and N-terminal pro-B-type natriuretic peptide in patients with stable coronary artery disease: a prognostic study within the CLARICOR Trial. Scandinavian Journal of Clinical & Laboratory Investigation, 71(1), 52-62. https://doi.org/10.3109/00365513.2010.538081, https://doi.org/10.3109/00365513.2010.538081

Vancouver

Harutyunyan MJ, Mathiasen AB, Winkel P, Gøtze JP, Hansen JF, Hildebrandt P o.a. High-sensitivity C-reactive protein and N-terminal pro-B-type natriuretic peptide in patients with stable coronary artery disease: a prognostic study within the CLARICOR Trial. Scandinavian Journal of Clinical & Laboratory Investigation. 2011 feb 1;71(1):52-62. https://doi.org/10.3109/00365513.2010.538081, https://doi.org/10.3109/00365513.2010.538081

Author

Harutyunyan, Marina J ; Mathiasen, Anders B ; Winkel, Per ; Gøtze, Jens P ; Hansen, Jørgen Fischer ; Hildebrandt, Per ; Jensen, Gorm Boje ; Hilden, Jørgen ; Jespersen, Christian M ; Kjøller, Erik ; Kolmos, Hans J ; Gluud, Christian ; Kastrup, Jens ; CLARICOR Trial Group. / High-sensitivity C-reactive protein and N-terminal pro-B-type natriuretic peptide in patients with stable coronary artery disease: a prognostic study within the CLARICOR Trial. I: Scandinavian Journal of Clinical & Laboratory Investigation. 2011 ; Bind 71, Nr. 1. s. 52-62.

Bibtex

@article{f91f80d4480048c8b5d03b5f93a7ca5c,
title = "High-sensitivity C-reactive protein and N-terminal pro-B-type natriuretic peptide in patients with stable coronary artery disease: a prognostic study within the CLARICOR Trial",
abstract = "BACKGROUND: Patients with stable coronary artery disease (CAD) have a poor prognosis. The aim of the study was to evaluate the extent to which serum high-sensitivity C-reactive protein (hs-CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) measurement alone or together could be prognostic biomarkers in patients with stable CAD.MATERIALS AND METHODS: During the 2.6-year follow-up period 270 patients among the 4264 patients with stable CAD in the CLARICOR trial suffered myocardial infarction (MI) and 377 died (187 cardiovascular deaths (CVD)).RESULTS: Serum NT-proBNP was significantly associated with MI (hazard ratio (HR), 1. 65 (refers to a 2.72 fold increase in serum level, p = 0.0005), CVD (HR, 2.42, p < 0.0005) and non-CVD (HR, 1.79, p < 0.0005). When correcting for hs-CRP, NT-proBNP was still significantly associated with MI (HR, 1.63, p = 0.0005), CVD (HR, 2.36, p < 0.0005) and non-CVD (HR, 1.66, p < 0.0005). Serum hs-CRP was compared to NT-proBNP less associated with MI (HR, 1.20, p = 0.001), CVD (HR, 1.39, p < 0.0005) and non-CVD (HR, 1.67, p < 0.0005). When corrected for NT-proBNP, hs-CRP was only associated with non-CVD (HR, 1.51, p < 0.0005). When adjusting for cardiovascular risk factors hs-CRP predicted non-CVD (HR, 1.46) and all-cause death (HR, 1.24) and NT-proBNP predicted MI (HR, 1.50), CVD (HR, 1.98), non-CVD (HR, 1.39), and all-cause death (HR, 1.62)(p < 0.0005 for all).CONCLUSION: Increased serum NT-proBNP was a stronger predictor of MI, cardiovascular death and non-cardiovascular death than hs-CRP in patients with stable CAD. Once NT-proBNP was taken into account, hs-CRP did not improve predictions.",
author = "Harutyunyan, {Marina J} and Mathiasen, {Anders B} and Per Winkel and G{\o}tze, {Jens P} and Hansen, {J{\o}rgen Fischer} and Per Hildebrandt and Jensen, {Gorm Boje} and J{\o}rgen Hilden and Jespersen, {Christian M} and Erik Kj{\o}ller and Kolmos, {Hans J} and Christian Gluud and Jens Kastrup and {CLARICOR Trial Group}",
year = "2011",
month = "2",
day = "1",
doi = "10.3109/00365513.2010.538081",
language = "English",
volume = "71",
pages = "52--62",
journal = "Scandinavian Journal of Clinical & Laboratory Investigation",
issn = "0036-5513",
publisher = "Taylor & Francis",
number = "1",

}

RIS

TY - JOUR

T1 - High-sensitivity C-reactive protein and N-terminal pro-B-type natriuretic peptide in patients with stable coronary artery disease: a prognostic study within the CLARICOR Trial

AU - Harutyunyan, Marina J

AU - Mathiasen, Anders B

AU - Winkel, Per

AU - Gøtze, Jens P

AU - Hansen, Jørgen Fischer

AU - Hildebrandt, Per

AU - Jensen, Gorm Boje

AU - Hilden, Jørgen

AU - Jespersen, Christian M

AU - Kjøller, Erik

AU - Kolmos, Hans J

AU - Gluud, Christian

AU - Kastrup, Jens

AU - CLARICOR Trial Group

PY - 2011/2/1

Y1 - 2011/2/1

N2 - BACKGROUND: Patients with stable coronary artery disease (CAD) have a poor prognosis. The aim of the study was to evaluate the extent to which serum high-sensitivity C-reactive protein (hs-CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) measurement alone or together could be prognostic biomarkers in patients with stable CAD.MATERIALS AND METHODS: During the 2.6-year follow-up period 270 patients among the 4264 patients with stable CAD in the CLARICOR trial suffered myocardial infarction (MI) and 377 died (187 cardiovascular deaths (CVD)).RESULTS: Serum NT-proBNP was significantly associated with MI (hazard ratio (HR), 1. 65 (refers to a 2.72 fold increase in serum level, p = 0.0005), CVD (HR, 2.42, p < 0.0005) and non-CVD (HR, 1.79, p < 0.0005). When correcting for hs-CRP, NT-proBNP was still significantly associated with MI (HR, 1.63, p = 0.0005), CVD (HR, 2.36, p < 0.0005) and non-CVD (HR, 1.66, p < 0.0005). Serum hs-CRP was compared to NT-proBNP less associated with MI (HR, 1.20, p = 0.001), CVD (HR, 1.39, p < 0.0005) and non-CVD (HR, 1.67, p < 0.0005). When corrected for NT-proBNP, hs-CRP was only associated with non-CVD (HR, 1.51, p < 0.0005). When adjusting for cardiovascular risk factors hs-CRP predicted non-CVD (HR, 1.46) and all-cause death (HR, 1.24) and NT-proBNP predicted MI (HR, 1.50), CVD (HR, 1.98), non-CVD (HR, 1.39), and all-cause death (HR, 1.62)(p < 0.0005 for all).CONCLUSION: Increased serum NT-proBNP was a stronger predictor of MI, cardiovascular death and non-cardiovascular death than hs-CRP in patients with stable CAD. Once NT-proBNP was taken into account, hs-CRP did not improve predictions.

AB - BACKGROUND: Patients with stable coronary artery disease (CAD) have a poor prognosis. The aim of the study was to evaluate the extent to which serum high-sensitivity C-reactive protein (hs-CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) measurement alone or together could be prognostic biomarkers in patients with stable CAD.MATERIALS AND METHODS: During the 2.6-year follow-up period 270 patients among the 4264 patients with stable CAD in the CLARICOR trial suffered myocardial infarction (MI) and 377 died (187 cardiovascular deaths (CVD)).RESULTS: Serum NT-proBNP was significantly associated with MI (hazard ratio (HR), 1. 65 (refers to a 2.72 fold increase in serum level, p = 0.0005), CVD (HR, 2.42, p < 0.0005) and non-CVD (HR, 1.79, p < 0.0005). When correcting for hs-CRP, NT-proBNP was still significantly associated with MI (HR, 1.63, p = 0.0005), CVD (HR, 2.36, p < 0.0005) and non-CVD (HR, 1.66, p < 0.0005). Serum hs-CRP was compared to NT-proBNP less associated with MI (HR, 1.20, p = 0.001), CVD (HR, 1.39, p < 0.0005) and non-CVD (HR, 1.67, p < 0.0005). When corrected for NT-proBNP, hs-CRP was only associated with non-CVD (HR, 1.51, p < 0.0005). When adjusting for cardiovascular risk factors hs-CRP predicted non-CVD (HR, 1.46) and all-cause death (HR, 1.24) and NT-proBNP predicted MI (HR, 1.50), CVD (HR, 1.98), non-CVD (HR, 1.39), and all-cause death (HR, 1.62)(p < 0.0005 for all).CONCLUSION: Increased serum NT-proBNP was a stronger predictor of MI, cardiovascular death and non-cardiovascular death than hs-CRP in patients with stable CAD. Once NT-proBNP was taken into account, hs-CRP did not improve predictions.

U2 - 10.3109/00365513.2010.538081

DO - 10.3109/00365513.2010.538081

M3 - Journal article

VL - 71

SP - 52

EP - 62

JO - Scandinavian Journal of Clinical & Laboratory Investigation

JF - Scandinavian Journal of Clinical & Laboratory Investigation

SN - 0036-5513

IS - 1

ER -

ID: 33141400