High-Rate Pacing Reduces Variability of Repolarization and Prevents Repolarization-Dependent Arrhythmias in Dogs With Chronic AV Block

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Standard

High-Rate Pacing Reduces Variability of Repolarization and Prevents Repolarization-Dependent Arrhythmias in Dogs With Chronic AV Block. / Oosterhoff, Peter; Thomsen, Morten Bækgaard; Maas, Joep N; Atteveld, Nico J M; Beekman, Jet D M; VAN Rijen, Harold V M; VAN DER Heyden, Marcel A G; Vos, Marc A.

I: Journal of Cardiovascular Electrophysiology, Bind 21, Nr. 12, 01.12.2010, s. 1384-91.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Oosterhoff, P, Thomsen, MB, Maas, JN, Atteveld, NJM, Beekman, JDM, VAN Rijen, HVM, VAN DER Heyden, MAG & Vos, MA 2010, 'High-Rate Pacing Reduces Variability of Repolarization and Prevents Repolarization-Dependent Arrhythmias in Dogs With Chronic AV Block', Journal of Cardiovascular Electrophysiology, bind 21, nr. 12, s. 1384-91. https://doi.org/10.1111/j.1540-8167.2010.01824.x

APA

Oosterhoff, P., Thomsen, M. B., Maas, J. N., Atteveld, N. J. M., Beekman, J. D. M., VAN Rijen, H. V. M., ... Vos, M. A. (2010). High-Rate Pacing Reduces Variability of Repolarization and Prevents Repolarization-Dependent Arrhythmias in Dogs With Chronic AV Block. Journal of Cardiovascular Electrophysiology, 21(12), 1384-91. https://doi.org/10.1111/j.1540-8167.2010.01824.x

Vancouver

Oosterhoff P, Thomsen MB, Maas JN, Atteveld NJM, Beekman JDM, VAN Rijen HVM o.a. High-Rate Pacing Reduces Variability of Repolarization and Prevents Repolarization-Dependent Arrhythmias in Dogs With Chronic AV Block. Journal of Cardiovascular Electrophysiology. 2010 dec 1;21(12):1384-91. https://doi.org/10.1111/j.1540-8167.2010.01824.x

Author

Oosterhoff, Peter ; Thomsen, Morten Bækgaard ; Maas, Joep N ; Atteveld, Nico J M ; Beekman, Jet D M ; VAN Rijen, Harold V M ; VAN DER Heyden, Marcel A G ; Vos, Marc A. / High-Rate Pacing Reduces Variability of Repolarization and Prevents Repolarization-Dependent Arrhythmias in Dogs With Chronic AV Block. I: Journal of Cardiovascular Electrophysiology. 2010 ; Bind 21, Nr. 12. s. 1384-91.

Bibtex

@article{bf76c5ba3c7943b5a1f51b5999e3489e,
title = "High-Rate Pacing Reduces Variability of Repolarization and Prevents Repolarization-Dependent Arrhythmias in Dogs With Chronic AV Block",
abstract = "High-rate pacing may have an inhibitory effect on the initiation of Torsade de Pointes arrhythmias (TdP). However, permanent pacing is only indicated in high-risk patients. We performed a proof of concept study into automatic overdrive pacing for prevention of drug-induced TdP, using short-term variability of repolarization (STV) as a feedback parameter of arrhythmic risk.Methods and Results: The minimal signal sampling frequency required for measuring STV was determined through computer simulation. Arrhythmogenic response to dofetilide (25 µg/kg/5minutes) was tested at two different paced heart rates (60–65 bpm vs 100–110 bpm) in 7 dogs with chronic atrioventricular block, while recording right and left ventricular (LV) monophasic action potential (MAP) and LV electrogram (EGM). Simulations showed a sampling frequency of 500 Hz is sufficient to capture relevant STV values. High-rate pacing prevented dofetilide-induced TdP seen at the low rate (low: 6/7 vs high: 1/7). At the low rate, STV from LV MAP duration increased before occurrence of spontaneous, ectopic activity and TdP (1.7 ± 0.6–3.0 ± 1.8 ms, P < 0.05), but at the high-rate STV did not change significantly (0.9 ± 0.2–1.5 ± 1.4 ms, NS). Regression analysis showed a close relation between STV calculated from LV MAP and from LV EGM (R2= 0.71).Conclusions: High-rate pacing increases repolarization reserve in dogs with chronic atrioventricular block, preventing dofetilide-induced TdP. Changes in repolarization reserve are reflected in values of STV.",
author = "Peter Oosterhoff and Thomsen, {Morten B{\ae}kgaard} and Maas, {Joep N} and Atteveld, {Nico J M} and Beekman, {Jet D M} and {VAN Rijen}, {Harold V M} and {VAN DER Heyden}, {Marcel A G} and Vos, {Marc A}",
year = "2010",
month = "12",
day = "1",
doi = "10.1111/j.1540-8167.2010.01824.x",
language = "English",
volume = "21",
pages = "1384--91",
journal = "Journal of Cardiovascular Electrophysiology",
issn = "1045-3873",
publisher = "Wiley-Blackwell",
number = "12",

}

RIS

TY - JOUR

T1 - High-Rate Pacing Reduces Variability of Repolarization and Prevents Repolarization-Dependent Arrhythmias in Dogs With Chronic AV Block

AU - Oosterhoff, Peter

AU - Thomsen, Morten Bækgaard

AU - Maas, Joep N

AU - Atteveld, Nico J M

AU - Beekman, Jet D M

AU - VAN Rijen, Harold V M

AU - VAN DER Heyden, Marcel A G

AU - Vos, Marc A

PY - 2010/12/1

Y1 - 2010/12/1

N2 - High-rate pacing may have an inhibitory effect on the initiation of Torsade de Pointes arrhythmias (TdP). However, permanent pacing is only indicated in high-risk patients. We performed a proof of concept study into automatic overdrive pacing for prevention of drug-induced TdP, using short-term variability of repolarization (STV) as a feedback parameter of arrhythmic risk.Methods and Results: The minimal signal sampling frequency required for measuring STV was determined through computer simulation. Arrhythmogenic response to dofetilide (25 µg/kg/5minutes) was tested at two different paced heart rates (60–65 bpm vs 100–110 bpm) in 7 dogs with chronic atrioventricular block, while recording right and left ventricular (LV) monophasic action potential (MAP) and LV electrogram (EGM). Simulations showed a sampling frequency of 500 Hz is sufficient to capture relevant STV values. High-rate pacing prevented dofetilide-induced TdP seen at the low rate (low: 6/7 vs high: 1/7). At the low rate, STV from LV MAP duration increased before occurrence of spontaneous, ectopic activity and TdP (1.7 ± 0.6–3.0 ± 1.8 ms, P < 0.05), but at the high-rate STV did not change significantly (0.9 ± 0.2–1.5 ± 1.4 ms, NS). Regression analysis showed a close relation between STV calculated from LV MAP and from LV EGM (R2= 0.71).Conclusions: High-rate pacing increases repolarization reserve in dogs with chronic atrioventricular block, preventing dofetilide-induced TdP. Changes in repolarization reserve are reflected in values of STV.

AB - High-rate pacing may have an inhibitory effect on the initiation of Torsade de Pointes arrhythmias (TdP). However, permanent pacing is only indicated in high-risk patients. We performed a proof of concept study into automatic overdrive pacing for prevention of drug-induced TdP, using short-term variability of repolarization (STV) as a feedback parameter of arrhythmic risk.Methods and Results: The minimal signal sampling frequency required for measuring STV was determined through computer simulation. Arrhythmogenic response to dofetilide (25 µg/kg/5minutes) was tested at two different paced heart rates (60–65 bpm vs 100–110 bpm) in 7 dogs with chronic atrioventricular block, while recording right and left ventricular (LV) monophasic action potential (MAP) and LV electrogram (EGM). Simulations showed a sampling frequency of 500 Hz is sufficient to capture relevant STV values. High-rate pacing prevented dofetilide-induced TdP seen at the low rate (low: 6/7 vs high: 1/7). At the low rate, STV from LV MAP duration increased before occurrence of spontaneous, ectopic activity and TdP (1.7 ± 0.6–3.0 ± 1.8 ms, P < 0.05), but at the high-rate STV did not change significantly (0.9 ± 0.2–1.5 ± 1.4 ms, NS). Regression analysis showed a close relation between STV calculated from LV MAP and from LV EGM (R2= 0.71).Conclusions: High-rate pacing increases repolarization reserve in dogs with chronic atrioventricular block, preventing dofetilide-induced TdP. Changes in repolarization reserve are reflected in values of STV.

U2 - 10.1111/j.1540-8167.2010.01824.x

DO - 10.1111/j.1540-8167.2010.01824.x

M3 - Journal article

VL - 21

SP - 1384

EP - 1391

JO - Journal of Cardiovascular Electrophysiology

JF - Journal of Cardiovascular Electrophysiology

SN - 1045-3873

IS - 12

ER -

ID: 33744508