Heritability of Tpeak-Tend Interval and T-wave Amplitude: A Twin Study

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Standard

Heritability of Tpeak-Tend Interval and T-wave Amplitude: A Twin Study. / Haarmark, Christian; Kyvik, Kirsten O; Vedel-Larsen, Esben; Budtz-Jørgensen, Esben; Kanters, Jørgen K.

I: Circulation. Cardiovascular genetics, Bind 4, Nr. 5, 11.08.2011, s. 516-22.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Haarmark, C, Kyvik, KO, Vedel-Larsen, E, Budtz-Jørgensen, E & Kanters, JK 2011, 'Heritability of Tpeak-Tend Interval and T-wave Amplitude: A Twin Study', Circulation. Cardiovascular genetics, bind 4, nr. 5, s. 516-22. https://doi.org/10.1161/CIRCGENETICS.111.959551

APA

Haarmark, C., Kyvik, K. O., Vedel-Larsen, E., Budtz-Jørgensen, E., & Kanters, J. K. (2011). Heritability of Tpeak-Tend Interval and T-wave Amplitude: A Twin Study. Circulation. Cardiovascular genetics, 4(5), 516-22. https://doi.org/10.1161/CIRCGENETICS.111.959551

Vancouver

Haarmark C, Kyvik KO, Vedel-Larsen E, Budtz-Jørgensen E, Kanters JK. Heritability of Tpeak-Tend Interval and T-wave Amplitude: A Twin Study. Circulation. Cardiovascular genetics. 2011 aug. 11;4(5):516-22. https://doi.org/10.1161/CIRCGENETICS.111.959551

Author

Haarmark, Christian ; Kyvik, Kirsten O ; Vedel-Larsen, Esben ; Budtz-Jørgensen, Esben ; Kanters, Jørgen K. / Heritability of Tpeak-Tend Interval and T-wave Amplitude: A Twin Study. I: Circulation. Cardiovascular genetics. 2011 ; Bind 4, Nr. 5. s. 516-22.

Bibtex

@article{0de5374079614debb86e7cc2e351100b,
title = "Heritability of Tpeak-Tend Interval and T-wave Amplitude: A Twin Study",
abstract = "BACKGROUND: -Tpeak-Tend interval (TpTe) and T-wave amplitude (Tamp) carry diagnostic and prognostic information regarding cardiac morbidity and mortality. Heart rate and QT interval are known to be heritable traits. The heritability of T-wave morphology parameters such as TpTe and Tamp is unknown. TpTe and Tamp were evaluated in a large sample of twins. METHODS AND RESULTS: -Twins from the GEMINAKAR study (611 pairs, 246 monozygotic, 365 dizygotic, aged 38±11 years, 49 % men) who had an ECG performed during 1997-2000 were included. Tamp was measured in leads V1 and V5. Duration variables (RR interval, QTpeak and QTend interval) were measured and averaged over three consecutive beats in lead V5. TpTe was calculated as the QTend and QTpeak interval difference. Heritability was assessed using structural equation models adjusting for age, gender and BMI. All models were reducible to a model of additive genetics and unique environment. All variables had considerable genetic components. Adjusted heritability estimates were: TpTe 46%, Tamp lead V1 34%, Tamp lead V5 47%, RR interval 55%, QT interval 67% and QTcB 42%. CONCLUSIONS: -RR interval, QT-interval, T-wave amplitude and Tpeak-Tend interval are heritable ECG parameters.",
author = "Christian Haarmark and Kyvik, {Kirsten O} and Esben Vedel-Larsen and Esben Budtz-J{\o}rgensen and Kanters, {J{\o}rgen K.}",
year = "2011",
month = aug,
day = "11",
doi = "10.1161/CIRCGENETICS.111.959551",
language = "English",
volume = "4",
pages = "516--22",
journal = "Circulation: Cardiovascular Genetics",
issn = "1942-325X",
publisher = "Lippincott Williams & Wilkins",
number = "5",

}

RIS

TY - JOUR

T1 - Heritability of Tpeak-Tend Interval and T-wave Amplitude: A Twin Study

AU - Haarmark, Christian

AU - Kyvik, Kirsten O

AU - Vedel-Larsen, Esben

AU - Budtz-Jørgensen, Esben

AU - Kanters, Jørgen K.

PY - 2011/8/11

Y1 - 2011/8/11

N2 - BACKGROUND: -Tpeak-Tend interval (TpTe) and T-wave amplitude (Tamp) carry diagnostic and prognostic information regarding cardiac morbidity and mortality. Heart rate and QT interval are known to be heritable traits. The heritability of T-wave morphology parameters such as TpTe and Tamp is unknown. TpTe and Tamp were evaluated in a large sample of twins. METHODS AND RESULTS: -Twins from the GEMINAKAR study (611 pairs, 246 monozygotic, 365 dizygotic, aged 38±11 years, 49 % men) who had an ECG performed during 1997-2000 were included. Tamp was measured in leads V1 and V5. Duration variables (RR interval, QTpeak and QTend interval) were measured and averaged over three consecutive beats in lead V5. TpTe was calculated as the QTend and QTpeak interval difference. Heritability was assessed using structural equation models adjusting for age, gender and BMI. All models were reducible to a model of additive genetics and unique environment. All variables had considerable genetic components. Adjusted heritability estimates were: TpTe 46%, Tamp lead V1 34%, Tamp lead V5 47%, RR interval 55%, QT interval 67% and QTcB 42%. CONCLUSIONS: -RR interval, QT-interval, T-wave amplitude and Tpeak-Tend interval are heritable ECG parameters.

AB - BACKGROUND: -Tpeak-Tend interval (TpTe) and T-wave amplitude (Tamp) carry diagnostic and prognostic information regarding cardiac morbidity and mortality. Heart rate and QT interval are known to be heritable traits. The heritability of T-wave morphology parameters such as TpTe and Tamp is unknown. TpTe and Tamp were evaluated in a large sample of twins. METHODS AND RESULTS: -Twins from the GEMINAKAR study (611 pairs, 246 monozygotic, 365 dizygotic, aged 38±11 years, 49 % men) who had an ECG performed during 1997-2000 were included. Tamp was measured in leads V1 and V5. Duration variables (RR interval, QTpeak and QTend interval) were measured and averaged over three consecutive beats in lead V5. TpTe was calculated as the QTend and QTpeak interval difference. Heritability was assessed using structural equation models adjusting for age, gender and BMI. All models were reducible to a model of additive genetics and unique environment. All variables had considerable genetic components. Adjusted heritability estimates were: TpTe 46%, Tamp lead V1 34%, Tamp lead V5 47%, RR interval 55%, QT interval 67% and QTcB 42%. CONCLUSIONS: -RR interval, QT-interval, T-wave amplitude and Tpeak-Tend interval are heritable ECG parameters.

U2 - 10.1161/CIRCGENETICS.111.959551

DO - 10.1161/CIRCGENETICS.111.959551

M3 - Journal article

C2 - 21836130

VL - 4

SP - 516

EP - 522

JO - Circulation: Cardiovascular Genetics

JF - Circulation: Cardiovascular Genetics

SN - 1942-325X

IS - 5

ER -

ID: 33910694