Heart specific up-regulation of genes for B-type and C-type natriuretic peptide receptors in diabetic mice

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Diabetes may cause cardiomyopathy characterized by cardiac fibrosis. Recent studies of genetically modified mice have elucidated a role of the natriuretic peptides (NP), type-A and type-B (ANP and BNP), and their common receptor [natriuretic peptide receptor (NPR), type-A] in development of cardiac fibrosis. The role of NP type-C (CNP) and NPR type-B (NPR-B) in the heart is less well established. In this study we examined if diabetes alters heart expression of the genes encoding the NP and its receptors.
TidsskriftEuropean Journal of Clinical Investigation
Udgave nummer2
Sider (fra-til)69-75
Antal sider7
StatusUdgivet - feb. 2006

ID: 100888776