Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined
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Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined. / Lundgren, Julie R.; Janus, Charlotte; Jensen, Simon B. K.; Juhl, Christian R.; Olsen, Lisa M.; Christensen, Rasmus M.; Svane, Maria S.; Bandholm, Thomas; Bojsen-Møller, Kirstine N.; Blond, Martin B.; Jensen, Jens-Erik B.; Stallknecht, Bente M.; Holst, Jens J.; Madsbad, Sten; Torekov, Signe S.
I: New England Journal of Medicine, Bind 384, 06.05.2021, s. 1719-1730.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined
AU - Lundgren, Julie R.
AU - Janus, Charlotte
AU - Jensen, Simon B. K.
AU - Juhl, Christian R.
AU - Olsen, Lisa M.
AU - Christensen, Rasmus M.
AU - Svane, Maria S.
AU - Bandholm, Thomas
AU - Bojsen-Møller, Kirstine N.
AU - Blond, Martin B.
AU - Jensen, Jens-Erik B.
AU - Stallknecht, Bente M.
AU - Holst, Jens J.
AU - Madsbad, Sten
AU - Torekov, Signe S.
PY - 2021/5/6
Y1 - 2021/5/6
N2 - Weight Loss Maintenance with Exercise and LiraglutideIn this trial, adults with obesity without diabetes were randomly assigned, after an 8-week low-calorie diet, to 1 year of placebo, an exercise program, liraglutide, or exercise plus liraglutide. Combined treatment with exercise and liraglutide improved healthy weight loss maintenance more than either treatment alone.BackgroundWeight regain after weight loss is a major problem in the treatment of persons with obesity.MethodsIn a randomized, head-to-head, placebo-controlled trial, we enrolled adults with obesity (body-mass index [the weight in kilograms divided by the square of the height in meters], 32 to 43) who did not have diabetes. After an 8-week low-calorie diet, participants were randomly assigned for 1 year to one of four strategies: a moderate-to-vigorous-intensity exercise program plus placebo (exercise group); treatment with liraglutide (3.0 mg per day) plus usual activity (liraglutide group); exercise program plus liraglutide therapy (combination group); or placebo plus usual activity (placebo group). End points with prespecified hypotheses were the change in body weight (primary end point) and the change in body-fat percentage (secondary end point) from randomization to the end of the treatment period in the intention-to-treat population. Prespecified metabolic health-related end points and safety were also assessed.ResultsAfter the 8-week low-calorie diet, 195 participants had a mean decrease in body weight of 13.1 kg. At 1 year, all the active-treatment strategies led to greater weight loss than placebo: difference in the exercise group, -4.1 kg (95% confidence interval [CI], -7.8 to -0.4; P=0.03); in the liraglutide group, -6.8 kg (95% CI, -10.4 to -3.1; PConclusionsA strategy combining exercise and liraglutide therapy improved healthy weight loss maintenance more than either treatment alone. (Funded by the Novo Nordisk Foundation and others; EudraCT number, ; ClinicalTrials.gov number, .)
AB - Weight Loss Maintenance with Exercise and LiraglutideIn this trial, adults with obesity without diabetes were randomly assigned, after an 8-week low-calorie diet, to 1 year of placebo, an exercise program, liraglutide, or exercise plus liraglutide. Combined treatment with exercise and liraglutide improved healthy weight loss maintenance more than either treatment alone.BackgroundWeight regain after weight loss is a major problem in the treatment of persons with obesity.MethodsIn a randomized, head-to-head, placebo-controlled trial, we enrolled adults with obesity (body-mass index [the weight in kilograms divided by the square of the height in meters], 32 to 43) who did not have diabetes. After an 8-week low-calorie diet, participants were randomly assigned for 1 year to one of four strategies: a moderate-to-vigorous-intensity exercise program plus placebo (exercise group); treatment with liraglutide (3.0 mg per day) plus usual activity (liraglutide group); exercise program plus liraglutide therapy (combination group); or placebo plus usual activity (placebo group). End points with prespecified hypotheses were the change in body weight (primary end point) and the change in body-fat percentage (secondary end point) from randomization to the end of the treatment period in the intention-to-treat population. Prespecified metabolic health-related end points and safety were also assessed.ResultsAfter the 8-week low-calorie diet, 195 participants had a mean decrease in body weight of 13.1 kg. At 1 year, all the active-treatment strategies led to greater weight loss than placebo: difference in the exercise group, -4.1 kg (95% confidence interval [CI], -7.8 to -0.4; P=0.03); in the liraglutide group, -6.8 kg (95% CI, -10.4 to -3.1; PConclusionsA strategy combining exercise and liraglutide therapy improved healthy weight loss maintenance more than either treatment alone. (Funded by the Novo Nordisk Foundation and others; EudraCT number, ; ClinicalTrials.gov number, .)
U2 - 10.1056/NEJMoa2028198
DO - 10.1056/NEJMoa2028198
M3 - Journal article
C2 - 33951361
VL - 384
SP - 1719
EP - 1730
JO - New England Journal of Medicine
JF - New England Journal of Medicine
SN - 0028-4793
ER -
ID: 262794505