Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes. / Albrechtsen, Nicolai Jacob Wewer; Albrechtsen, Reidar; Bremholm, l; Svendsen, Berit; Kuhre, Rune Ehrenreich; Poulsen, Steen Seier; Christiansen, Charlotte Bayer; Jensen, Elisa Pouline; Janus, Charlotte; Hilsted, Linda; Deacon, Carolyn F.; Hartmann, Bolette; Holst, Jens Juul.

I: Cell Reports, Bind 17, Nr. 11, 2016, s. 2845-2856.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Albrechtsen, NJW, Albrechtsen, R, Bremholm, L, Svendsen, B, Kuhre, RE, Poulsen, SS, Christiansen, CB, Jensen, EP, Janus, C, Hilsted, L, Deacon, CF, Hartmann, B & Holst, JJ 2016, 'Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes', Cell Reports, bind 17, nr. 11, s. 2845-2856. https://doi.org/10.1016/j.celrep.2016.11.051

APA

Albrechtsen, N. J. W., Albrechtsen, R., Bremholm, L., Svendsen, B., Kuhre, R. E., Poulsen, S. S., ... Holst, J. J. (2016). Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes. Cell Reports, 17(11), 2845-2856. https://doi.org/10.1016/j.celrep.2016.11.051

Vancouver

Albrechtsen NJW, Albrechtsen R, Bremholm L, Svendsen B, Kuhre RE, Poulsen SS o.a. Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes. Cell Reports. 2016;17(11):2845-2856. https://doi.org/10.1016/j.celrep.2016.11.051

Author

Albrechtsen, Nicolai Jacob Wewer ; Albrechtsen, Reidar ; Bremholm, l ; Svendsen, Berit ; Kuhre, Rune Ehrenreich ; Poulsen, Steen Seier ; Christiansen, Charlotte Bayer ; Jensen, Elisa Pouline ; Janus, Charlotte ; Hilsted, Linda ; Deacon, Carolyn F. ; Hartmann, Bolette ; Holst, Jens Juul. / Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes. I: Cell Reports. 2016 ; Bind 17, Nr. 11. s. 2845-2856.

Bibtex

@article{30ea7f74bc134f7a90d42707c7717512,
title = "Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes",
abstract = "Incretin-based therapies are widely used for type 2 diabetes and now also for obesity, but they are associated with elevated plasma levels of pancreatic enzymes and perhaps a modestly increased risk of acute pancreatitis. However, little is known about the effects of the incretin hormone glucagon-like peptide 1 (GLP-1) on the exocrine pancreas. Here, we identify GLP-1 receptors on pancreatic acini and analyze the impact of receptor activation in humans, rodents, isolated acini, and cell lines from the exocrine pancreas. GLP-1 did not directly stimulate amylase or lipase release. However, we saw that GLP-1 induces phosphorylation of the epidermal growth factor receptor and activation of Foxo1, resulting in cell growth with concomitant enzyme release. Our work uncovers GLP-1-induced signaling pathways in the exocrine pancreas and suggests that increases in amylase and lipase levels in subjects treated with GLP-1 receptor agonists reflect adaptive growth rather than early-stage pancreatitis.",
author = "Albrechtsen, {Nicolai Jacob Wewer} and Reidar Albrechtsen and l Bremholm and Berit Svendsen and Kuhre, {Rune Ehrenreich} and Poulsen, {Steen Seier} and Christiansen, {Charlotte Bayer} and Jensen, {Elisa Pouline} and Charlotte Janus and Linda Hilsted and Deacon, {Carolyn F.} and Bolette Hartmann and Holst, {Jens Juul}",
year = "2016",
doi = "10.1016/j.celrep.2016.11.051",
language = "English",
volume = "17",
pages = "2845--2856",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "11",

}

RIS

TY - JOUR

T1 - Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes

AU - Albrechtsen, Nicolai Jacob Wewer

AU - Albrechtsen, Reidar

AU - Bremholm, l

AU - Svendsen, Berit

AU - Kuhre, Rune Ehrenreich

AU - Poulsen, Steen Seier

AU - Christiansen, Charlotte Bayer

AU - Jensen, Elisa Pouline

AU - Janus, Charlotte

AU - Hilsted, Linda

AU - Deacon, Carolyn F.

AU - Hartmann, Bolette

AU - Holst, Jens Juul

PY - 2016

Y1 - 2016

N2 - Incretin-based therapies are widely used for type 2 diabetes and now also for obesity, but they are associated with elevated plasma levels of pancreatic enzymes and perhaps a modestly increased risk of acute pancreatitis. However, little is known about the effects of the incretin hormone glucagon-like peptide 1 (GLP-1) on the exocrine pancreas. Here, we identify GLP-1 receptors on pancreatic acini and analyze the impact of receptor activation in humans, rodents, isolated acini, and cell lines from the exocrine pancreas. GLP-1 did not directly stimulate amylase or lipase release. However, we saw that GLP-1 induces phosphorylation of the epidermal growth factor receptor and activation of Foxo1, resulting in cell growth with concomitant enzyme release. Our work uncovers GLP-1-induced signaling pathways in the exocrine pancreas and suggests that increases in amylase and lipase levels in subjects treated with GLP-1 receptor agonists reflect adaptive growth rather than early-stage pancreatitis.

AB - Incretin-based therapies are widely used for type 2 diabetes and now also for obesity, but they are associated with elevated plasma levels of pancreatic enzymes and perhaps a modestly increased risk of acute pancreatitis. However, little is known about the effects of the incretin hormone glucagon-like peptide 1 (GLP-1) on the exocrine pancreas. Here, we identify GLP-1 receptors on pancreatic acini and analyze the impact of receptor activation in humans, rodents, isolated acini, and cell lines from the exocrine pancreas. GLP-1 did not directly stimulate amylase or lipase release. However, we saw that GLP-1 induces phosphorylation of the epidermal growth factor receptor and activation of Foxo1, resulting in cell growth with concomitant enzyme release. Our work uncovers GLP-1-induced signaling pathways in the exocrine pancreas and suggests that increases in amylase and lipase levels in subjects treated with GLP-1 receptor agonists reflect adaptive growth rather than early-stage pancreatitis.

U2 - 10.1016/j.celrep.2016.11.051

DO - 10.1016/j.celrep.2016.11.051

M3 - Journal article

VL - 17

SP - 2845

EP - 2856

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 11

ER -

ID: 169969826