Glucagon-like peptide-1 elicits vasodilation in adipose tissue and skeletal muscle in healthy men

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Glucagon-like peptide-1 elicits vasodilation in adipose tissue and skeletal muscle in healthy men. / Asmar, Ali; Asmar, Meena; Simonsen, Lene; Madsbad, Sten; Holst, Jens J; Hartmann, Bolette; Sorensen, Charlotte M; Bülow, Jens.

I: Physiological Reports, Bind 5, Nr. 3, e13073, 02.2017.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Asmar, A, Asmar, M, Simonsen, L, Madsbad, S, Holst, JJ, Hartmann, B, Sorensen, CM & Bülow, J 2017, 'Glucagon-like peptide-1 elicits vasodilation in adipose tissue and skeletal muscle in healthy men', Physiological Reports, bind 5, nr. 3, e13073. https://doi.org/10.14814/phy2.13073

APA

Asmar, A., Asmar, M., Simonsen, L., Madsbad, S., Holst, J. J., Hartmann, B., ... Bülow, J. (2017). Glucagon-like peptide-1 elicits vasodilation in adipose tissue and skeletal muscle in healthy men. Physiological Reports, 5(3), [ e13073]. https://doi.org/10.14814/phy2.13073

Vancouver

Asmar A, Asmar M, Simonsen L, Madsbad S, Holst JJ, Hartmann B o.a. Glucagon-like peptide-1 elicits vasodilation in adipose tissue and skeletal muscle in healthy men. Physiological Reports. 2017 feb;5(3). e13073. https://doi.org/10.14814/phy2.13073

Author

Asmar, Ali ; Asmar, Meena ; Simonsen, Lene ; Madsbad, Sten ; Holst, Jens J ; Hartmann, Bolette ; Sorensen, Charlotte M ; Bülow, Jens. / Glucagon-like peptide-1 elicits vasodilation in adipose tissue and skeletal muscle in healthy men. I: Physiological Reports. 2017 ; Bind 5, Nr. 3.

Bibtex

@article{6469af281add4c94a867d6a2bbbfbeef,
title = "Glucagon-like peptide-1 elicits vasodilation in adipose tissue and skeletal muscle in healthy men",
abstract = "In healthy subjects, we recently demonstrated that during acute administration of GLP-1, cardiac output increased significantly, whereas renal blood flow remained constant. We therefore hypothesize that GLP-1 induces vasodilation in other organs, for example, adipose tissue, skeletal muscle, and/or splanchnic tissues. Nine healthy men were examined twice in random order during a 2-hour infusion of either GLP-1 (1.5 pmol kg(-1) min(-1)) or saline. Cardiac output was continuously estimated noninvasively concomitantly with measurement of intra-arterial blood pressure. Subcutaneous, abdominal adipose tissue blood flow (ATBF) was measured by the (133)Xenon clearance technique. Leg and splanchnic blood flow were measured by Fick's Principle, using indocyanine green as indicator. In the GLP-1 study, cardiac output increased significantly together with a significant increase in arterial pulse pressure and heart rate compared with the saline study. Subcutaneous, abdominal ATBF and leg blood flow increased significantly during the GLP-1 infusion compared with saline, whereas splanchnic blood flow response did not differ between the studies. We conclude that in healthy subjects, GLP-1 increases cardiac output acutely due to a GLP-1-induced vasodilation in adipose tissue and skeletal muscle together with an increase in cardiac work.",
author = "Ali Asmar and Meena Asmar and Lene Simonsen and Sten Madsbad and Holst, {Jens J} and Bolette Hartmann and Sorensen, {Charlotte M} and Jens B{\"u}low",
note = "{\circledC} 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.",
year = "2017",
month = "2",
doi = "10.14814/phy2.13073",
language = "English",
volume = "5",
journal = "Physiological Reports",
issn = "2051-817X",
publisher = "Wiley Periodicals, Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Glucagon-like peptide-1 elicits vasodilation in adipose tissue and skeletal muscle in healthy men

AU - Asmar, Ali

AU - Asmar, Meena

AU - Simonsen, Lene

AU - Madsbad, Sten

AU - Holst, Jens J

AU - Hartmann, Bolette

AU - Sorensen, Charlotte M

AU - Bülow, Jens

N1 - © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

PY - 2017/2

Y1 - 2017/2

N2 - In healthy subjects, we recently demonstrated that during acute administration of GLP-1, cardiac output increased significantly, whereas renal blood flow remained constant. We therefore hypothesize that GLP-1 induces vasodilation in other organs, for example, adipose tissue, skeletal muscle, and/or splanchnic tissues. Nine healthy men were examined twice in random order during a 2-hour infusion of either GLP-1 (1.5 pmol kg(-1) min(-1)) or saline. Cardiac output was continuously estimated noninvasively concomitantly with measurement of intra-arterial blood pressure. Subcutaneous, abdominal adipose tissue blood flow (ATBF) was measured by the (133)Xenon clearance technique. Leg and splanchnic blood flow were measured by Fick's Principle, using indocyanine green as indicator. In the GLP-1 study, cardiac output increased significantly together with a significant increase in arterial pulse pressure and heart rate compared with the saline study. Subcutaneous, abdominal ATBF and leg blood flow increased significantly during the GLP-1 infusion compared with saline, whereas splanchnic blood flow response did not differ between the studies. We conclude that in healthy subjects, GLP-1 increases cardiac output acutely due to a GLP-1-induced vasodilation in adipose tissue and skeletal muscle together with an increase in cardiac work.

AB - In healthy subjects, we recently demonstrated that during acute administration of GLP-1, cardiac output increased significantly, whereas renal blood flow remained constant. We therefore hypothesize that GLP-1 induces vasodilation in other organs, for example, adipose tissue, skeletal muscle, and/or splanchnic tissues. Nine healthy men were examined twice in random order during a 2-hour infusion of either GLP-1 (1.5 pmol kg(-1) min(-1)) or saline. Cardiac output was continuously estimated noninvasively concomitantly with measurement of intra-arterial blood pressure. Subcutaneous, abdominal adipose tissue blood flow (ATBF) was measured by the (133)Xenon clearance technique. Leg and splanchnic blood flow were measured by Fick's Principle, using indocyanine green as indicator. In the GLP-1 study, cardiac output increased significantly together with a significant increase in arterial pulse pressure and heart rate compared with the saline study. Subcutaneous, abdominal ATBF and leg blood flow increased significantly during the GLP-1 infusion compared with saline, whereas splanchnic blood flow response did not differ between the studies. We conclude that in healthy subjects, GLP-1 increases cardiac output acutely due to a GLP-1-induced vasodilation in adipose tissue and skeletal muscle together with an increase in cardiac work.

U2 - 10.14814/phy2.13073

DO - 10.14814/phy2.13073

M3 - Journal article

VL - 5

JO - Physiological Reports

JF - Physiological Reports

SN - 2051-817X

IS - 3

M1 - e13073

ER -

ID: 173294583