Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short-bowel patients with no colon

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P B Jeppesen, B Hartmann, J Thulesen, J Graff, J Lohmann, B S Hansen, F Tofteng, Steen Seier Poulsen, J L Madsen, J J Holst, P B Mortensen

Glucagon-like peptide 2 (GLP-2) is intestinotrophic, antisecretory, and transit-modulating in rodents, and it is mainly secreted from the intestinal mucosa of the terminal ileum and colon after food ingestion. We assessed the effect of GLP-2 on the gastrointestinal function in patients without a terminal ileum and colon who have functional short-bowel syndrome with severe malabsorption of wet weight (>1.5 kg/day) and energy (>2.3 MJ/day) and no postprandial secretion of GLP-2.
OriginalsprogEngelsk
TidsskriftGastroenterology
Vol/bind120
Udgave nummer4
Sider (fra-til)806-815
Antal sider10
ISSN0016-5085
StatusUdgivet - mar. 2001

ID: 168197